New endoscopic diagnosis using immunostaining and NBI in patients with IgG4-related sclerosing cholangitis
| Project/Area Number |
15K09047
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Yokohama City University |
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Principal Investigator |
KUBOTA kensuke 横浜市立大学, 医学研究科, 教授 (70381499)
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| Co-Investigator(Kenkyū-buntansha) |
中島 淳 横浜市立大学, 医学研究科, 教授 (30326037)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2017: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Keywords | IgG4関連硬化性胆管炎 / 自己免疫性膵炎 / 内視鏡生検 / NBI / 肝門部胆管癌 / IgG4関連硬化胆管炎 / 肝門部胆管癌との鑑別 / 内視鏡的生検 / IgG4 / FOXP3 / CD163 |
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| Outline of Final Research Achievements |
Endoscopic differences between proximal IgG4-SC and Klatskin tumor were studied. Cholangiography findings, endosonographic features (Narrow Band Imaging of ampulla of Vater, continuous symmetric mucosal lesion to the hilar part [CSML]), endoscopic biopsy results (bile duct and ampulla of Vater) using immunostaining were compared. For a differential diagnosis between IgG4-SC (n = 35) and Klatskin tumor (n = 47), ampullary biopsy and endoscopic findings enhanced NBI are useful in IgG4-SC. CSML were noted significantly more often in the IgG4-SC group (P < 0.01). Endoscopic features using immunostaining, NBI and CSML might provide a diagnostic clue for IgG4-SC.
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Report
(4 results)
Research Products
(13 results)
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[Journal Article] Low-dose maintenance steroid treatment could reduce the relapse rate in patients with type 1 autoimmune pancreatitis: a long-term Japanese multicenter analysis of 510 patients.2017
Author(s)
Kubota K, Kamisawa T, Okazaki K, Kawa S, Hirano K, Hirooka Y, Uchida K, Shiomi H, Ohara H, Shimizu K, Arakura N, Kanno A, Sakagami J, Itoi T, Ito T, Ueki T, Nishino T, Inui K, Mizuno N, Yoshida H, Sugiyama M, Iwasaki E, Irisawa A, Shimosegawa T, Takeyama Y, Chiba T.
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Journal Title
J Gastroenterol.
Volume: 52
Issue: 8
Pages: 955-964
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Anterior approach for right hepatectomy with hanging maneuver for hepatocellular carcinoma: a multi-institutional propensity score-matching study.2017
Author(s)
Beppu T, Imai K, Okuda K, Eguchi S, Kitahara K, Taniai N, Ueno S, Shirabe K, Ohta M, Kondo K, Nanashima A, Noritomi T, Shiraishi M, Takami Y, Okamoto K, Kikuchi K, Baba H, Fujioka H.
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Journal Title
J Hepatobiliary Pancreat Sci.
Volume: 24
Issue: 3
Pages: 127-136
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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