New endoscopic diagnosis using immunostaining and NBI in patients with IgG4-related sclerosing cholangitis

• Project/Area Number: 15K09047
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Yokohama City University
• Principal Investigator: KUBOTA kensuke 横浜市立大学, 医学研究科, 教授 (70381499)
• Co-Investigator(Kenkyū-buntansha): 中島 淳 横浜市立大学, 医学研究科, 教授 (30326037)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000); Fiscal Year 2017: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000); Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
• Keywords: IgG4関連硬化性胆管炎 / 自己免疫性膵炎 / 内視鏡生検 / NBI / 肝門部胆管癌 / IgG4関連硬化胆管炎 / 肝門部胆管癌との鑑別 / 内視鏡的生検 / IgG4 / FOXP3 / CD163

Outline of Final Research Achievements

Endoscopic differences between proximal IgG4-SC and Klatskin tumor were studied. Cholangiography findings, endosonographic features (Narrow Band Imaging of ampulla of Vater, continuous symmetric mucosal lesion to the hilar part [CSML]), endoscopic biopsy results (bile duct and ampulla of Vater) using immunostaining were compared. For a differential diagnosis between IgG4-SC (n = 35) and Klatskin tumor (n = 47), ampullary biopsy and endoscopic findings enhanced NBI are useful in IgG4-SC. CSML were noted significantly more often in the IgG4-SC group (P < 0.01). Endoscopic features using immunostaining, NBI and CSML might provide a diagnostic clue for IgG4-SC.

Research Products

• [Journal Article] 自己免疫性膵炎に伴う乳頭腫大 (2018)
  • Author(s): 窪田賢輔
  • Journal Title: 消化器内視鏡 Volume: 印刷中
• [Journal Article] IgG4関連硬化性胆管炎；ＩｇＧ４-SC (2018)
  • Author(s): 窪田賢輔
  • Journal Title: 肝臓クリニカルアップデート Volume: 印刷中
• [Journal Article] Low-dose maintenance steroid treatment could reduce the relapse rate in patients with type 1 autoimmune pancreatitis: a long-term Japanese multicenter analysis of 510 patients. (2017)
  • Author(s): Kubota K, Kamisawa T, Okazaki K, Kawa S, Hirano K, Hirooka Y, Uchida K, Shiomi H, Ohara H, Shimizu K, Arakura N, Kanno A, Sakagami J, Itoi T, Ito T, Ueki T, Nishino T, Inui K, Mizuno N, Yoshida H, Sugiyama M, Iwasaki E, Irisawa A, Shimosegawa T, Takeyama Y, Chiba T.
  • Journal Title: J Gastroenterol. Volume: 52 Issue: 8 Pages: 955-964
  • DOI: 10.1007/s00535-016-1302-1
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Anterior approach for right hepatectomy with hanging maneuver for hepatocellular carcinoma: a multi-institutional propensity score-matching study. (2017)
  • Author(s): Beppu T, Imai K, Okuda K, Eguchi S, Kitahara K, Taniai N, Ueno S, Shirabe K, Ohta M, Kondo K, Nanashima A, Noritomi T, Shiraishi M, Takami Y, Okamoto K, Kikuchi K, Baba H, Fujioka H.
  • Journal Title: J Hepatobiliary Pancreat Sci. Volume: 24 Issue: 3 Pages: 127-136
  • DOI: 10.1002/jhbp.431
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] 胆管癌の内視鏡的診断とドレナージ (2017)
  • Author(s): 窪田賢輔
  • Journal Title: 最新医学 Volume: 37 Pages: 233-240
• [Presentation] PLASTIC STENTS, RATHER THAN METALLIC STENTS, CAN CONTRIBUTE TO THE SUCCESS OF RE-INTERVENTION IN PATIENTS WITH INOPERABLE KLATSKIN TUMOR (2018)
  • Author(s): Akito Iwasaki, Kensuke Kubota
  • Organizer: DDW 2018 (Washington DC, USA)
  • Int'l Joint Research
• [Presentation] Clinical differences of IgG4-related sclerosing cholangitis between isolated type and type associated with autoimmune pancreatitis (2017)
  • Author(s): Yuri Kato, Kensuke Kubota
  • Organizer: DDW 2016 (San Diego,USA)
  • Int'l Joint Research
• [Presentation] Can endoscopic ultrasonography performed as an outpatient procedure enable a differential diagnosis between hilar-type IgG4-related sclerosing cholangitis and Klatskin tumor? (2017)
  • Author(s): Akito Iwasaki, Kensuke Kubota
  • Organizer: DDW 2017 (Chicago,USA)
  • Int'l Joint Research
• [Presentation] Can endoscopic ultrasonography performed as an outpatient procedure enable a differential diagnosis between hilar-type IgG4-related sclerosing cholangitis and Klatskin tumor? (2017)
  • Author(s): Akito Iwasaki, Kensuke Kubotra, et al
  • Organizer: 米国消化器病週間DDW2017
  • Place of Presentation: 米国 Chicago
  • Int'l Joint Research
• [Presentation] Clinical differences of IgG4-related sclerosing cholangitis between isolated type and type associated with autoimmune pancreatitis (2016)
  • Author(s): Yuri Kato, Kensuke kubota, et al.
  • Organizer: 米国消化器病週間DDW2016
  • Place of Presentation: 米国 Sandiego
  • Int'l Joint Research
• [Book] IgG4related sclerosing cholangitis (2018)
  • Author(s): Kamisawa T, Kim MH, Kubota K, et al.,
  • Publisher: Springer
• [Book] 最新IgG4関連疾患 ６ 自己免疫性膵炎 治療 (2015)
  • Author(s): 岡崎和一、川 茂幸 編 （窪田賢輔分担）
  • Total Pages: 178
  • Publisher: 診断と治療社
• [Book] utoimmune pancreatitis Sialadenitis and Dacryoadenitis:IgG4-Related Mikulicz’s Disease Would precede autoimmune pancreatitis and be likily to relapse (2015)
  • Author(s): T Kamisawa, JG Chung 編 （窪田賢輔分担）
  • Total Pages: 209
  • Publisher: Springer-Verlag Berlin Heidelberg