Establishment of the biliary cancer risk assessment system using a deoxycholic acid-induced gallbladder carcinogenesis mouse model.
| Project/Area Number |
15K09048
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Nagoya City University |
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Principal Investigator |
Kuno Toshiya 名古屋市立大学, 大学院医学研究科, 研究員 (00345779)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 化学発癌 / 胆嚢 / 胆管 / 胆嚢がん / マウス / ハムスター / 化学物質誘発 / 胆道発癌 / デオキシコール酸 / リスク評価 |
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| Outline of Final Research Achievements |
This study was aimed to establish a gallbladder carcinogenesis mouse model for the risk assessment of the biliary tract carcinogen candidate.
In short term experiment, N-methyl-N-formylhydrazine (MFH) increased proliferative activity and the DNA damage in male ICR mouse gallbladder/biliary tract epithelium. Then, two-step gallbladder carcinogenesis experiment using MFH and deoxycholic acid administration to male ICR mice were performed. At the termination, no tumor was observed in the gallbladder/biliary tract histopathologically.
Thus, it was revealed that the meddle term MFH-deoxycholic acid exposure to ICR mouse did not have a gallbladder carcinogenic effect.
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Report
(4 results)
Research Products
(5 results)
