| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
This study was aimed to establish a gallbladder carcinogenesis mouse model for the risk assessment of the biliary tract carcinogen candidate.
In short term experiment, N-methyl-N-formylhydrazine (MFH) increased proliferative activity and the DNA damage in male ICR mouse gallbladder/biliary tract epithelium. Then, two-step gallbladder carcinogenesis experiment using MFH and deoxycholic acid administration to male ICR mice were performed. At the termination, no tumor was observed in the gallbladder/biliary tract histopathologically.
Thus, it was revealed that the meddle term MFH-deoxycholic acid exposure to ICR mouse did not have a gallbladder carcinogenic effect.
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