| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
|---|
| Outline of Final Research Achievements |
Pathophysiology of type 1 autoimmune pancreatitis (AIP) is still unclear. We previously reported that M2 macrophages might play an important role in type 1 AIP. Recently, it has been reported that basophils regulate differentiation to M2 macrophages. We investigated basophils from the pancreatic tissue and peripheral blood of individuals with type 1 AIP.
Basophils were detected in pancreatic tissues in 10 of 13 patients with type 1 AIP. Stimulation of TLR2 and/or TLR4, which were expressed on basophils in the pancreas, activated basophils in peripheral blood.In flow cytometric analysis, the ratios of basophils activated by TLR4 stimulation in type 1 AIP and atopic dermatitis were significantly higher than those in healthy subjects. Levels of basophils activated by TLR2 stimulation were higher in seven cases with type 1 AIP cases.Basophils activated via TLR 4 (or 2) signaling may play an important role in the pathophysiology of type 1 AIP.
|
