Study on the role of regulatory B cells and their therapeutic application to acute and autoimmune pancreatitis
| Project/Area Number |
15K09053
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Gastroenterology
|
|---|
| Research Institution | Kansai Medical University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
|---|
| Keywords | 制御性B細胞 / 急性膵炎 / 自己免疫性膵炎 / 細胞移入 / CD19 / インターロイキン10 / toll like receptor / 自然免疫 / Toll-like receptor / toll-like receptor |
|---|
| Outline of Final Research Achievements |
To clarify the role of regulatory B cells in the development of acute pancreatitis, we studied a murine model of experimental pancreatitis induced by cerulein and lipopolysaccharide. There was no difference in the severity of pancreatitis between wild type and B cell-deficient mice. Pancreatitis deteriorated in CD19-deficient mice that lack regulatory B cells. However, administration of interleukin 10-producing B10 cells ameliorated pancreatitis in CD19-deficient mice. In contrast with wild type mice, CD19-deficient mice developed autoimmune pancreatitis by administration of poly I:C. Taken together, regulatory B cells are supposed to be involved in the suppression of pancreatitis, suggesting the usefulness of them in the treatment of pancreatitis.
|
Report
(4 results)
Research Products
(24 results)
-
-
-
[Journal Article] Basophils activated via TLR signaling may contribute to pathophysiology of type 1 autoimmune pancreatitis.2018
Author(s)
Yanagawa M, Uchida K, Ando Y, Tomiyama T, Yamaguchi T, Ikeura T, Fukui T, Nishio A, Uemura Y, Miyara T, Okamoto H, Satoi S, Okazaki K.
-
Journal Title
J Gastroenterol.
Volume: 53
Issue: 3
Pages: 449-460
DOI
Related Report
Peer Reviewed / Open Access
-
-
-
-
-
-
[Journal Article] Comparison of neutrophil infiltration between type 1 and type 2 autoimmune pancreatitis.2015
Author(s)
Mitsuyama T, Uchida K, Sumimoto K, Fukui Y, Ikeura T, Fukui T, Nishio A, Shikata N, Uemura Y, Satoi S, Mizuno N, Notohara K, Shimosegawa T, Zamboni G, Frulloni L, Okazaki K.
-
Journal Title
Pancreatology.
Volume: Epub ahead of print
Issue: 3
Pages: 271-280
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
-
-
-
-
[Journal Article] Phosphorylation of Smad2/3 at the specific linker threonine residue indicates slow-cycling esophageal stem-like cells before re-entry to the cell cycle2014
Author(s)
Takahashi Y, Fukui T, Kishimoto M, Suzuki R, Mitsuyama T, Sumimoto K, Okazaki T, Sakao M, Sakaguchi Y, Yoshida K, Uchida K, Nishio A, Matsuzaki K, Okazaki K
-
Journal Title
Diseases of the Esophagus
Volume: -
Issue: 2
Pages: 107-115
DOI
Related Report
Peer Reviewed / Open Access
-
-
-
-
-
-
-
-
-
-
-
