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Study on the role of regulatory B cells and their therapeutic application to acute and autoimmune pancreatitis

Research Project

Project/Area Number 15K09053
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Gastroenterology
Research InstitutionKansai Medical University

Principal Investigator

NISHIO Akiyoshi  関西医科大学, 医学部, 准教授 (50362463)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords制御性B細胞 / 急性膵炎 / 自己免疫性膵炎 / 細胞移入 / CD19 / インターロイキン10 / toll like receptor / 自然免疫 / Toll-like receptor / toll-like receptor
Outline of Final Research Achievements

To clarify the role of regulatory B cells in the development of acute pancreatitis, we studied a murine model of experimental pancreatitis induced by cerulein and lipopolysaccharide. There was no difference in the severity of pancreatitis between wild type and B cell-deficient mice. Pancreatitis deteriorated in CD19-deficient mice that lack regulatory B cells. However, administration of interleukin 10-producing B10 cells ameliorated pancreatitis in CD19-deficient mice. In contrast with wild type mice, CD19-deficient mice developed autoimmune pancreatitis by administration of poly I:C. Taken together, regulatory B cells are supposed to be involved in the suppression of pancreatitis, suggesting the usefulness of them in the treatment of pancreatitis.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (24 results)

All 2018 2017 2016 2015 2014

All Journal Article (13 results) (of which Peer Reviewed: 13 results,  Open Access: 4 results,  Acknowledgement Compliant: 2 results) Presentation (11 results) (of which Int'l Joint Research: 6 results)

  • [Journal Article] Pathophysiology of the appendix in ulcerative colitis2018

    • Author(s)
      Mitsunobu Matsushita
    • Journal Title

      American Journal of Gastroenterology

      Volume: 113 Issue: 4 Pages: 622-622

    • DOI

      10.1038/ajg.2017.506

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inductiom of PIR-A/B+- DCs in the in vitro inflammatory condition and their immunoregulatory function2018

    • Author(s)
      Fumi Matsui
    • Journal Title

      Journal of Gastroenterology

      Volume: 印刷中 Issue: 10 Pages: 1131-1141

    • DOI

      10.1007/s00535-018-1447-1

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Basophils activated via TLR signaling may contribute to pathophysiology of type 1 autoimmune pancreatitis.2018

    • Author(s)
      Yanagawa M, Uchida K, Ando Y, Tomiyama T, Yamaguchi T, Ikeura T, Fukui T, Nishio A, Uemura Y, Miyara T, Okamoto H, Satoi S, Okazaki K.
    • Journal Title

      J Gastroenterol.

      Volume: 53 Issue: 3 Pages: 449-460

    • DOI

      10.1007/s00535-017-1390-6

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Techniques of ERCP with a conventional endoscope in pancreatoduodenectomy anatomy2017

    • Author(s)
      Mitsunobu Matsushita
    • Journal Title

      Gastrointestinal Endoscopy

      Volume: 86 Issue: 4 Pages: 747-748

    • DOI

      10.1016/j.gie.2017.05.007

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Smad2/3 linker phosphorylation is a possible marker of pancreatic stem/progenitor cells in the regenerative phase of acute pancreatitis2017

    • Author(s)
      Masayuki Sakao
    • Journal Title

      Pancreas

      Volume: 46 Pages: 605-613

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pathogenesis and carcinogenesis of the appendix in ulcerative colitis2017

    • Author(s)
      Mitsunobu Matsushita
    • Journal Title

      American Journal of Gastroenterology

      Volume: 112 Issue: 1 Pages: 184-184

    • DOI

      10.1038/ajg.2016.312

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Endoscopic and/or laparoscopic full-layer resection of gastric ectopic pancreas arising from submucosal and muscular layers2016

    • Author(s)
      Mitsunobu Matsushita
    • Journal Title

      Gastrointestinal Endoscopy

      Volume: 84 Issue: 3 Pages: 547-547

    • DOI

      10.1016/j.gie.2016.02.035

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Inverted appendix: final diagnosis or endometriosis2016

    • Author(s)
      Mitsunobu Matsushita
    • Journal Title

      American Journal of Gastroenterology

      Volume: 111 Issue: 5 Pages: 746-746

    • DOI

      10.1038/ajg.2016.69

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Comparison of neutrophil infiltration between type 1 and type 2 autoimmune pancreatitis.2015

    • Author(s)
      Mitsuyama T, Uchida K, Sumimoto K, Fukui Y, Ikeura T, Fukui T, Nishio A, Shikata N, Uemura Y, Satoi S, Mizuno N, Notohara K, Shimosegawa T, Zamboni G, Frulloni L, Okazaki K.
    • Journal Title

      Pancreatology.

      Volume: Epub ahead of print Issue: 3 Pages: 271-280

    • DOI

      10.1016/j.pan.2015.03.005

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Smad2/3 linker phosphorylation is a possible marker of cancer stem cells and correlates with carcinogenesis in a mouse model of colitis-associated colorectal cancer2015

    • Author(s)
      Ryo Suzuki
    • Journal Title

      Journal of Crohn’s and Colitis

      Volume: 9 Issue: 7 Pages: 565-574

    • DOI

      10.1093/ecco-jcc/jjv073

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Immunoregulatory function of PIR-A/B+ DCs in the inflammatory responses of dextran sodium sulfate-induced colitis2014

    • Author(s)
      Kurishima A, Inaba M, Sakaguchi Y, Fukui T, Uchida K, Nishio A, Nomura S, Okazaki K
    • Journal Title

      Journal of Gastroenterology

      Volume: 49 Issue: 10 Pages: 1367-1377

    • DOI

      10.1007/s00535-013-0879-x

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Possible involvement of Toll-like receptor 7 in the development of type 1 autoimmune pancreatitis2014

    • Author(s)
      Fukui Y, Uchida K, Sakaguchi Y, Fukui T, Nishio A, Shikata N, Sakaida N, Uemura Y, Satoi S, Okazaki K
    • Journal Title

      Journal of Gastroenterology

      Volume: 50 Issue: 4 Pages: 435-444

    • DOI

      10.1007/s00535-014-0977-4

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Phosphorylation of Smad2/3 at the specific linker threonine residue indicates slow-cycling esophageal stem-like cells before re-entry to the cell cycle2014

    • Author(s)
      Takahashi Y, Fukui T, Kishimoto M, Suzuki R, Mitsuyama T, Sumimoto K, Okazaki T, Sakao M, Sakaguchi Y, Yoshida K, Uchida K, Nishio A, Matsuzaki K, Okazaki K
    • Journal Title

      Diseases of the Esophagus

      Volume: - Issue: 2 Pages: 107-115

    • DOI

      10.1111/dote.12277

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 急性膵炎再生期におけるSmad2/3リンカー部リン酸化の前駆細胞マーカーとしての可能性2017

    • Author(s)
      坂尾 将幸
    • Organizer
      第48回日本膵臓学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 膵炎の病態解明を目指した最新の基礎研究 慢性膵炎と1型自己免疫性膵炎における膵内神経システムの免疫組織化学的検討2017

    • Author(s)
      加藤 孝太
    • Organizer
      第48回日本膵臓学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Phosphorylation of Smad2/3 at specific linker threonine during pancreatitis indicates slow-cycling stem-like cells2016

    • Author(s)
      Masayuki Sakao
    • Organizer
      Asian Pacific Digestive Week 2017
    • Place of Presentation
      神戸国際展示場(兵庫県神戸市)
    • Year and Date
      2016-11-03
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Analysis of neutrophil infiltration in type 1 and type 2 autoimmune pacreatitis2016

    • Author(s)
      Kazushige Uchida
    • Organizer
      第47回日本膵臓学会大会
    • Place of Presentation
      仙台国際センター(宮城県仙台)
    • Year and Date
      2016-08-04
    • Related Report
      2016 Research-status Report
  • [Presentation] 自己免疫性膵炎(1型・2型)における好中球浸潤機序の違いについて2016

    • Author(s)
      内田 一茂
    • Organizer
      第53回日本消化器免疫学会総会
    • Place of Presentation
      ホテルニューオータニ大阪(大阪府大阪市)
    • Year and Date
      2016-07-14
    • Related Report
      2016 Research-status Report
  • [Presentation] Repeated stimulation with zymosan, a cell wall component of Saccharomyces Cerevisiae, induces chronic pancreatitis in mice2015

    • Author(s)
      Masahiro Takeo
    • Organizer
      Asian Pacific Digestive Week (APDW) 2015
    • Place of Presentation
      Taipei International Convention Center (中華民国、台北)
    • Year and Date
      2015-12-03
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Carcinogenic and stem cell-like phenotypes of Smad2/3 linker phosphorylation in a mouse model of colitis-associated colorectal cancer2015

    • Author(s)
      Toshiro Fukui
    • Organizer
      Asian Pacific Digestive Week (APDW) 2015
    • Place of Presentation
      Taipei International Convention Center (中華民国、台北)
    • Year and Date
      2015-12-03
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] The pathophysiological role of toll-like receptor signaling in type 1 autoimmune pancreatitis2015

    • Author(s)
      Kazushige Uchida
    • Organizer
      Asian Pacific Digestive Week (APDW) 2015
    • Place of Presentation
      Taipei International Convention Center (中華民国、台北)
    • Year and Date
      2015-12-03
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Analysis of neutrophil infiltration in type 1 and type2 autoimmune pancreatitis2015

    • Author(s)
      Toshiyuki Mitsuyama
    • Organizer
      115th Annual Meeting of the American Gastroenterological Association (DDW2016)
    • Place of Presentation
      Washington Convention Center (米国、ワシントンDC)
    • Year and Date
      2015-05-17
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] The Role of Toll-like Receptor Signaling in the Pathophysiology of Type 1 Autoimmune Pancreatitis2015

    • Author(s)
      Kazushige Uchida
    • Organizer
      115th Annual Meeting of the American Gastroenterological Association (DDW2016)
    • Place of Presentation
      Washington Convention Center (米国、ワシントンDC)
    • Year and Date
      2015-05-17
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] eIF2α脱リン酸化抑制を介した小胞体ストレス軽減による膵炎改善効果の検討2015

    • Author(s)
      岡崎 敬
    • Organizer
      第101回日本消化器病学会総会
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2015-04-23
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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