| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
To clarify the role of regulatory B cells in the development of acute pancreatitis, we studied a murine model of experimental pancreatitis induced by cerulein and lipopolysaccharide. There was no difference in the severity of pancreatitis between wild type and B cell-deficient mice. Pancreatitis deteriorated in CD19-deficient mice that lack regulatory B cells. However, administration of interleukin 10-producing B10 cells ameliorated pancreatitis in CD19-deficient mice. In contrast with wild type mice, CD19-deficient mice developed autoimmune pancreatitis by administration of poly I:C. Taken together, regulatory B cells are supposed to be involved in the suppression of pancreatitis, suggesting the usefulness of them in the treatment of pancreatitis.
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