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Development of novel early diagnostic method targeted specific glycosylated lumican in pancreatic cancer

Research Project

Project/Area Number 15K09054
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Gastroenterology
Research InstitutionKindai University

Principal Investigator

YAMAMOTO Tetsushi  近畿大学, 薬学部, 助教 (20453920)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywordsルミカン / 膵臓癌 / 糖鎖修飾 / プロテオグリカン / 細胞外基質
Outline of Final Research Achievements

It has been suggested that there are organ or tissue specific lumican based on different glycosylation. In this study, we performed purification of lumican that is produced by gastrointestinal cancer cells using transfection of lumican expression vector to investigate whether there is a specific glycosylated lumican that is produced by pancreatic cancer cells. We successfully purified the lumican that was produced by esophageal and pancreatic cancer cells. Then, we examined the difference in expression pattern of these lumican, and found differentially expressed lumican that was considered pancreatic cancer cell specific. Thus, this lumican might be a novel target for development of diagnostic method for pancreatic cancer.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (4 results)

All 2017 2016

All Journal Article (3 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 3 results,  Open Access: 3 results) Presentation (1 results)

  • [Journal Article] Effect of dark-colored maple syrup on cell proliferation of human gastrointestinal cancer cell2017

    • Author(s)
      Yamamoto Tetsushi、Sato Kanta、Kubota Yuika、Mitamura Kuniko、Taga Atsushi
    • Journal Title

      Biomed Rep.

      Volume: 7 Issue: 1 Pages: 6-10

    • DOI

      10.3892/br.2017.910

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Proteomic profile of the lens in a streptozotocin-induced diabetic rat model using shotgun proteomics2017

    • Author(s)
      Nagai Noriaki、Yamamoto Tetsushi、Mitamura Kuniko、Taga Atsushi
    • Journal Title

      Biomed Rep.

      Volume: 7 Issue: 5 Pages: 445-450

    • DOI

      10.3892/br.2017.988

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Identification of aldolase A as a potential diagnostic biomarker for colorectal cancer based on proteomic analysis using formalin-fixed paraffin-embedded tissue.2016

    • Author(s)
      Yamamoto T, Kudo M, Peng WX, Takata H, Takakura H, Teduka K, Fujii T, Mitamura K, Taga A, Uchida E, Naito Z
    • Journal Title

      Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine

      Volume: 37 Issue: 10 Pages: 13595-13606

    • DOI

      10.1007/s13277-016-5275-8

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] 細胞外基質 Lumican の発現抑制による新規膵臓癌細 胞増殖抑制法の開発2017

    • Author(s)
      山本 哲志, 谷田 和香奈, 橋本 知樹, 三田村 邦子, 多賀 淳
    • Organizer
      日本薬学会大137年会
    • Place of Presentation
      仙台、国際センター
    • Year and Date
      2017-03-25
    • Related Report
      2016 Research-status Report

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Published: 2015-04-16   Modified: 2020-01-20  

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