Development of novel early diagnostic method targeted specific glycosylated lumican in pancreatic cancer
Project/Area Number |
15K09054
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Gastroenterology
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Research Institution | Kindai University |
Principal Investigator |
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
Keywords | ルミカン / 膵臓癌 / 糖鎖修飾 / プロテオグリカン / 細胞外基質 |
Outline of Final Research Achievements |
It has been suggested that there are organ or tissue specific lumican based on different glycosylation. In this study, we performed purification of lumican that is produced by gastrointestinal cancer cells using transfection of lumican expression vector to investigate whether there is a specific glycosylated lumican that is produced by pancreatic cancer cells. We successfully purified the lumican that was produced by esophageal and pancreatic cancer cells. Then, we examined the difference in expression pattern of these lumican, and found differentially expressed lumican that was considered pancreatic cancer cell specific. Thus, this lumican might be a novel target for development of diagnostic method for pancreatic cancer.
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Report
(4 results)
Research Products
(4 results)
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[Journal Article] Identification of aldolase A as a potential diagnostic biomarker for colorectal cancer based on proteomic analysis using formalin-fixed paraffin-embedded tissue.2016
Author(s)
Yamamoto T, Kudo M, Peng WX, Takata H, Takakura H, Teduka K, Fujii T, Mitamura K, Taga A, Uchida E, Naito Z
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Journal Title
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine
Volume: 37
Issue: 10
Pages: 13595-13606
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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