Measurement of gastrointestinal function using 3-D endoscope
Project/Area Number |
15K09057
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Gastroenterology
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Research Institution | Osaka University |
Principal Investigator |
Kenji Watabe 大阪大学, 医学部附属病院, 准教授 (50379244)
|
Co-Investigator(Kenkyū-buntansha) |
辻井 正彦 大阪大学, 医学系研究科, 招へい教授 (40303937)
山田 憲嗣 大阪大学, 医学系研究科, 特任教授(常勤) (70364114)
|
Project Period (FY) |
2015-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | 機能性消化管疾患 / 3D内視鏡 / 3次元内視鏡 / 計測 / 距離 / 容積 / コンプライアンス / 運動 / 蠕動波 / パノラマ |
Outline of Final Research Achievements |
The functional gastrointestinal disorders (FGID) are common in daily practice. Their pathophysiology includes impaired gastrointestinal motility and distention. World standard test for FGIDs requires specialized equipment and is rarely used in Japan. We previously developed technique of 3-D measurements using stereo endoscopy which mounted a compound eye system. Here, we examined its basic specification for measuring gastrointestinal function. Major findings are as follows. Stereo endoscope measured the movement of peristaltic wave which was set to 2 mm/s as 1.74 mm/s (13% error). Stereo endoscope measured the diameter of a cylinder which was built 20 mm in diameter as 19.6 mm (3% error) and the volume of a half-sphere which was built 20 mm in diameter as 1.9mm3 (theoretical value 2.09, 9% error). These findings demonstrate the potential of our stereo endoscopy to measure the gastrointestinal function precisely.
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Report
(4 results)
Research Products
(7 results)
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[Journal Article] Tissue drug concentrations of anti-tumor necrosis factor agents are associated with the long-term outcome of patients with Crohn's disease.2017
Author(s)
Yoshihara T, Shinzaki S, Kawai S, Fujii H, Iwatani S, Yamaguchi T, Araki M, Hiyama S, Inoue T, Hayashi Y, Watabe K, Iijima H, Takehara T.
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Journal Title
Inflamm Bowel Dis.
Volume: 23(12)
Issue: 12
Pages: 2172-2179
DOI
Related Report
Peer Reviewed
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[Journal Article] p53 functional deficiency in human colon cancer cells promotes fibroblast-mediated angiogenesis and tumor growth.2016
Author(s)
Hayashi Y, Tsujii M, Kodama T, Akasaka T, Kondo J, Hikita H, Inoue T, Tsujii Y, Maekawa A, Yoshii S, Shinzaki S, Watabe K, Tomita Y, Inoue M, Tatsumi T, Iijima H, Takehara T.
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Journal Title
Carcinogenesis.
Volume: 37
Issue: 10
Pages: 972-984
DOI
Related Report
Peer Reviewed
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[Journal Article] The effectiveness of an anti-human IL-6 receptor monoclonal antibody combined with chemotherapy to target colon cancer stem-like cells.2015
Author(s)
Ying J, Tsujii M, Kondo J, Hayashi Y, Kato M, Akasaka T, Inoue T, Shiraishi E, Inoue T, Hiyama S, Tsujii Y, Maekawa A, Kawai S, Fujinaga T, Araki M, Shinzaki S, Watabe K, Nishida T, Iijima H, Takehara T.
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Journal Title
Int J Oncol.
Volume: 46
Issue: 4
Pages: 1151-1159
DOI
Related Report
Peer Reviewed
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[Journal Article] Integrated diagnostic strategy for the invasion depth of early gastric cancer by conventional endoscopy and EUS.2015
Author(s)
sujii Y, Kato M, Inoue T, Yoshii S, Nagai K, Fujinaga T, Maekawa A, Hayashi Y, Akasaka T, Shinzaki S, Watabe K, Nishida T, Iijima H, Tsujii M, Takehara T.
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Journal Title
Gastrointest Endosc.
Volume: 15
Issue: 3
Pages: 452-459
DOI
Related Report
Peer Reviewed