| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
Most strokes in patients with atrial fibrillation (AF) are believed to be cardioembolic, caused by the embolism of left atrial thrombi. As shown by the well-known Virchow triad, thrombus formation in the left atrium (LA) can result from decreased blood flow, increased endocardial dysfunction in the LA, and enhanced blood coagulability. We examined whether AF affects gene expression remotely in the liver, which is a major source of prothrombotic molecules. DNA microarray analysis revealed marked changes in the gene expression profile of human liver of patients with AF. The extrinsic prothrombin activation pathway showed the most prominent change. Twelve hours of rapid atrial pacing also markedly altered the gene expression profile of rat liver, which was eliminated by IL-6 neutralizing antibody. These findings suggest the presence of cadiohepatic interaction mediated by the IL-6/STAT3 signaling pathway in AF and AF-related thromboembolism.
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