Evaluation by Frequency Analysis of Surface Electrocardiogram and Rotor Mapping in Left Atrum

Research Project

Project/Area Number	15K09076
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Cardiovascular medicine
Research Institution	Nagoya University
Principal Investigator	Yasuya Inden 名古屋大学, 医学系研究科, 准教授 (10359747)
Co-Investigator(Kenkyū-buntansha)	室原豊明名古屋大学, 医学系研究科, 教授 (90299503) 吉田直樹名古屋大学, 医学部附属病院, 病院助教 (80612762) 柳澤哲名古屋大学, 医学系研究科, 寄附講座助教 (30768578) 山崎正俊名古屋大学, 環境医学研究所, 特任助教 (30627328)
Project Period (FY)	2015-04-01 – 2018-03-31
Project Status	Completed (Fiscal Year 2017)
Budget Amount *help	¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000) Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000) Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000) Fiscal Year 2015: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords	心房細動 / rotor / アブレーション / 周波数解析 / ローターマッピング / スパイラルリエントリー / 心房細動周波数解析
Outline of Final Research Achievements	Dominant frequency (DF) of atrial fibrillation (AF) reflects atrial electrical activity. We retrospectively investigated 78 patients who underwent catheter ablation due to persistent AF. The high DF of lead aVL and V1 was a predictor of arrhythmia recurrence after persistent AF ablation. Electrical rotors may be targets in ablations for persistent atrial fibrillation. Unipolar electrograms in left atrium were recorded with using basket catheter, and we analyzed rotational activities by NavX. rotors were recognized in anterior and posterior LA. We performed PV isolation and delivered RF application to the rotors. AF terminated in some patients and more patients maintained sinus rhythm. Rotors could be able to be recognized by use of basket catheter and EnSite system in patients with persistent AF and may be the target of ablation in persistent AF next to PVI.