Termination mechanisms of atrial fibrillation by rotor-based ablation and establishment of patient-tailored atrial fibrillation therapy
| Project/Area Number |
15K09077
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cardiovascular medicine
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| Research Institution | The University of Tokyo (2017)
Nagoya University (2015-2016) |
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Principal Investigator |
YAMAZAKI MASATOSHI 東京大学, 大学院工学系研究科(工学部), 特任研究員(主任) (30627328)
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| Co-Investigator(Kenkyū-buntansha) |
佐久間 一郎 東京大学, 大学院工学系研究科(工学部), 教授 (50178597)
本荘 晴朗 名古屋大学, 環境医学研究所, 准教授 (70262912)
芦原 貴司 滋賀医科大学, 医学部, 講師 (80396259)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 心房細動 / ローター / アブレーション / 位相分散 / ダントロレン / 心房梗塞 |
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| Outline of Final Research Achievements |
Atrial fibrillation (AF) is the most common sustained atrial arrhythmia. Recently, several physicians have demonstrated the feasibility of localizing fibrillatory reentrant sources (rotor) with a 64-spine catheter-enabled electrogram phase analysis. Preliminary results with this approach have shown substantial improvement of the ablation outcome. Regardless of the ablation strategy, however, the mechanisms by which electrogram-based point ablation may succeed or fail are unknown. Here, we employed advanced optical mapping techniques to examine AF dynamics before and after rotor-based ablation for AF. In 2 animals AF terminated, while in the remainder 5 animals the post-ablation maximum region of dominant frequency domains relocated to far region. These results suggest that ablation of meandering pathway may be better strategy than rotor-based ablation of AF.
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Report
(4 results)
Research Products
(29 results)
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[Journal Article] Atrial Infarction-induced Spontaneous Focal Discharges and Atrial Fibrillation in Sheep: Role of Dantrolene-Sensitive Aberrant Ryanodine Receptor Calcium Release.2018
Author(s)
Avula UM, Yamazaki M, Hernandez J, Valdivia C, Chu A, Rojas-Pena A, Kaur K, Ramos-Mondragon R, Anumonwo J, Nattel S, Valdivia H, Kalifa J.
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Journal Title
Circ Arrhythm Electrophysiol.
Volume: in press
Issue: 3
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Wholly Patient-tailored Ablation of Atrial Fibrillation Guided by Spatio-Temporal Dispersion of Electrograms in the Absence of Pulmonary Vein s Isolation.2017
Author(s)
Seitz J, Bars C, Theodore G, Beurtheret S, Lellouche N, Bremondy M, Ferracci A, Faure J, Penaranda G, Yamazaki M, Avula UM, Curel L, Siame S, Berenfeld O, Pisapia A, Kalifa J.
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Journal Title
J Am Coll. Cardiol
Volume: 69(3)
Issue: 3
Pages: 303-321
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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