| Project/Area Number |
15K09077
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cardiovascular medicine
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| Research Institution | The University of Tokyo (2017)
Nagoya University (2015-2016) |
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Principal Investigator |
YAMAZAKI MASATOSHI 東京大学, 大学院工学系研究科(工学部), 特任研究員(主任) (30627328)
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| Co-Investigator(Kenkyū-buntansha) |
佐久間 一郎 東京大学, 大学院工学系研究科(工学部), 教授 (50178597)
本荘 晴朗 名古屋大学, 環境医学研究所, 准教授 (70262912)
芦原 貴司 滋賀医科大学, 医学部, 講師 (80396259)
|
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 心房細動 / ローター / アブレーション / 位相分散 / ダントロレン / 心房梗塞 |
|---|
| Outline of Final Research Achievements |
Atrial fibrillation (AF) is the most common sustained atrial arrhythmia. Recently, several physicians have demonstrated the feasibility of localizing fibrillatory reentrant sources (rotor) with a 64-spine catheter-enabled electrogram phase analysis. Preliminary results with this approach have shown substantial improvement of the ablation outcome. Regardless of the ablation strategy, however, the mechanisms by which electrogram-based point ablation may succeed or fail are unknown. Here, we employed advanced optical mapping techniques to examine AF dynamics before and after rotor-based ablation for AF. In 2 animals AF terminated, while in the remainder 5 animals the post-ablation maximum region of dominant frequency domains relocated to far region. These results suggest that ablation of meandering pathway may be better strategy than rotor-based ablation of AF.
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