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Multilateral analysis and ablation treatment on arrhythmogenic substrate in idiopathic ventricular fibrillation

Research Project

Project/Area Number 15K09083
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Cardiovascular medicine
Research InstitutionNational Cardiovascular Center Research Institute

Principal Investigator

Nagase Satoshi  国立研究開発法人国立循環器病研究センター, 病院, 医長 (50397907)

Co-Investigator(Kenkyū-buntansha) 中村 一文  岡山大学, 医歯薬学総合研究科, 准教授 (10335630)
森田 宏  岡山大学, 医歯薬学総合研究科, 教授 (50322227)
西井 伸洋  岡山大学, 医歯薬学総合研究科, 講師 (50537214)
中川 晃志  岡山大学, 大学病院, 助教 (70726132)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords特発性心室細動 / カテーテルアブレーション / 低電位領域 / 埋め込み型除細動器 / 心室遅延電位 / J波 / Purkinje電位 / 異常電位 / 心臓電気生理検査 / 遺伝子変異 / 心室細動
Outline of Final Research Achievements

Although the number of cases of idiopathic ventricular fibrillation gradually increases, as the affected individual itself is a rare disease, it is still in the process of collecting data. We also examined and analyzed the Brugada syndrome considered to be included in idiopathic ventricular fibrillation in a broad sense. In some cases of idiopathic ventricular fibrillation, it was found that there is a case in which low voltage area was partially recognized by ventricular endocardial mapping, and the effectiveness of ablation treatment is expected.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (3 results)

All 2017 2015

All Journal Article (1 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (1 results) Funded Workshop (1 results)

  • [Journal Article] Local activation delay exacerbates local J-ST elevation in the epicardium: Electrophysiological substrate in Brugada syndrome.2017

    • Author(s)
      Kataoka N, Nagase S, Kamakura T, Noda T, Aiba T, Kusano K.
    • Journal Title

      Heart Rhythm Case Report

      Volume: 12 Issue: 12 Pages: 595-598

    • DOI

      10.1016/j.hrcr.2017.10.005

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Low Amplitude Type 1 Electrocardiogram as a Predictor of Fatal Arrhythmic Events in Patients with Brugada Syndrome2017

    • Author(s)
      Satoshi Nagase, Tsukasa Kamakura, Mitsuru Wada, Kohei Ishibashi, Yuko Inoue, Koji Miyamoto, Hideo Okamura, Takashi Noda, Takeshi Aiba, Satoshi Yasuda, Hisao Ogawa, Shiro Kamakura, Kengo F Kusano
    • Organizer
      日本循環器学会総会
    • Related Report
      2017 Annual Research Report
  • [Funded Workshop] Heart Rhythm 20152015

    • Place of Presentation
      Boston, Massachusetts, USA
    • Year and Date
      2015-05-13
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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