Mitochondrial ALDH2 Genotype and Heart Failure
Project/Area Number |
15K09084
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Cardiovascular medicine
|
Research Institution | Hiroshima University |
Principal Investigator |
Kihara Yasuki 広島大学, 医歯薬保健学研究科(医), 教授 (40214853)
|
Co-Investigator(Kenkyū-buntansha) |
東 幸仁 広島大学, 原爆放射線医科学研究所, 教授 (40346490)
|
Project Period (FY) |
2015-04-01 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
|
Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | ミトコンドリア / アルデヒド脱水酸化酵素 / 心不全 / 心房細動 / 心筋症 / 飲酒 / 血管内皮機能 / 酸化ストレス / iPS細胞 / アルデヒド脱水素酵素 |
Outline of Final Research Achievements |
Mitochondrial Aldehyde dehydrogenase 2 (ALDH2) is a crucial controller of subcellular oxidative stress and the subsequent cellular damages. Its SNP causes substantial depression of the enzymatic activity, and it could be a potent background of several cardiovascular diseases such as arrhythmia and heart failure. We tested hypothesis that, in Japanese, paroxysmal and persistent atrial fibrillation (Afib, an indicator of the second stage cardiac damage) may precipitate among the ALDH2 hetero-/homo-genetic population. By comparing control (non-Afib) group, however, there were no apparent precipitation of ALDH2 heterogeneity. In contrast, Afib group showed rather less ALDH2 heterogeneity. Effects of longstanding alcohol consumption may cover the hypothetic frames.
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Report
(4 results)
Research Products
(358 results)
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[Presentation] Impairment of Endothelial Function in Patients Receiving Antihypertensive Drug Treatment Regardless of Blood Pressure Level: FMD-J Study2018
Author(s)
Maruhashi T, Higashi Y, Iwamoto Y, Kajikawa M, Kishimoto S, Matsui S, Hashimoto H, Hidaka T, Noma K, Tomiyama H, Takase B, Yamashina A, Kihara Y
Organizer
第82回日本循環器学会学術集会
Related Report
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[Presentation] A common SCN10A variant may contribute to decrease SCN5A expression by promoting SCN5A promoter methylation in Brugada syndrome patients2018
Author(s)
Okamura S, Nakano Y, Okubo Y, Hironobe N, Amioka M, Tomomori S, Matsumura H, Motoda C, Tokuyama T, Sairaku A, Kihara Y
Organizer
第82回日本循環器学会学術集会
Related Report
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[Presentation] Semaphorin 3A Polymorphism Modifies Autonomic Function in Brugada Syndrome2018
Author(s)
Tokuyama T, Nakano Y, Okamura S, Okubo Y, Hironobe N, Amioka M, Tomomori S, Matsumura H, Motoda C, Sairaku A, Kihara Y
Organizer
第82回日本循環器学会学術集会
Related Report
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[Presentation] HCN4 Gene polymorphisms are Associated with Susceptibility to Tachycardia Induced Cardiomyopathy in Patients with Atrial Fibrillation2018
Author(s)
Nakano Y, Ochi H, Onohara Y, Sairaku A,Tokuyama T, Motoda C, Matsumura H,Tomomori S, Amioka M,Hironobe N, Okubo Y, Okamura S, Chayama K, Kihara Y
Organizer
第82回日本循環器学会学術集会
Related Report
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[Presentation] In Aortic stenosis Patients, Monocyte-to-Lymphocyte Ratio is Related to Thrombogenesis and Associated with Left atrial Appendage Contraction2018
Author(s)
Fukuda Y, Takaekou Y, Susawa H, Sumimoto Y, Ikenaga H, Utsunomiya H, Ishibashi K, Hidaka T, Kurisu S, Kihara Y
Organizer
第82回日本循環器学会学術集会
Related Report
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[Presentation] Coronary Artery Calcium is Linked with Left Ventricular Diastolic Parameters Derived from ECG-gated SPECT in Patients with Normal Myocardial Perfusion2018
Author(s)
Nitta K, Kurisu S, Sumimoto Y, Ikenaga H, Ishibashi K, Fukuda Y, Nakamoto Y, Senoo A, Kitagawa T, Yamamoto H, Kihara Y
Organizer
第82回日本循環器学会学術集会
Related Report
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[Presentation] Risk Stratification of Ventricular Fibrillation in Brugada Syndrome Using Clinical and Molecular Biological Parameters is useful for Deciding an Optimal Therapeutic Strategy2017
Author(s)
Nakano Y, Kawazoe H, Ochi H, Sairaku A, Tokuyama T, Matsumura H, Tomomori S, Amioka M, Hironobe N, Motoda C, Onohara Y, Chayama K, Kihara Y
Organizer
第81回日本循環器学会学術集会
Place of Presentation
石川県
Year and Date
2017-03-17
Related Report
Invited
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[Presentation] Variants of Aldehyde Dehydrogenase 2 and Alcohol Dehydrogenase Genes are Associated with Atrial Fibrillation2017
Author(s)
Nakano Y, Ochi H, Onohara Y, Sairaku A, Tokuyama T, Matsumura H, Tomomori S, Amioka M, Hironobe N, Motoda C, Oda N, Chayama K, Kihara Y
Organizer
第81回日本循環器学会学術集会
Place of Presentation
石川県
Year and Date
2017-03-17
Related Report
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[Presentation] 歯磨きの時間と頻度に基づく口腔衛生が血管内皮機能に及ぼす影響2017
Author(s)
松井翔吾,梶川正人,丸橋達也,岩本明倫,小田望,岸本真治,日髙貴之,中島歩,野間玄督,木原康樹,東幸仁
Organizer
第2回日本血管不全学会学術集会・総会
Related Report
-
[Presentation] 突発性アルドステロン症における血管内皮機能とRho-associated kinase活性について2017
Author(s)
岸本真治,松井翔吾,小田望,梶川正人,岩本由美子,丸橋達也,日髙貴之,中島歩,野間玄督,木原康樹,東幸仁
Organizer
第2回日本血管不全学会学術集会・総会
Related Report
-
[Presentation] 高血圧症における血管内皮機能障害:FMD-Japan Study2017
Author(s)
梶川正人,丸橋達也,松井翔吾,小田望,岸本真治,野間玄督,木原康樹,冨山博史,高瀬凡平,山科章,東幸仁
Organizer
第2回日本血管不全学会学術集会・総会
Related Report
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[Presentation] 酸化成分低減クロロゲン酸含有コーヒーは食後の血管内皮障害を抑制する2017
Author(s)
梶川正人,丸橋達也,岸本真治,松井翔吾,野間玄督,日髙貴之,栗栖智,中野由紀子,木原康樹,渡辺卓也,刀禰寛,日比壮信,大崎紀子,桂木能久,東幸仁
Organizer
第40回日本高血圧学会総会
Related Report
-
[Presentation] 新規血管内皮機能測定装置改良型enclosed zone flow-mediated vasodilation (ezFMD)の有用性2017
Author(s)
梶川正人,森本陽香,松井翔吾,小田望,平野陽豊,丸橋達也,岸本真治,岩本由美子,日髙貴之,中島歩,野間玄督,木原康樹,鵜川貞二,辻敏夫,東幸仁
Organizer
第40回日本高血圧学会総会
Related Report
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[Presentation] PITX2遺伝子多型は洞機能を低下させ心房細動発症に寄与している2017
Author(s)
友森俊介,中野由紀子,西樂顕典,德山丈仁,元田親章,松村誠也,網岡道孝,廣延直也,大久保陽策,岡村祥央,木原康樹
Organizer
第111回日本循環器学会中国地方会
Related Report
-
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[Presentation] Vascular function is impaired in subjects with decreased circulating level of pigment epithelium-derived factor2017
Author(s)
Kajikawa M, Higashi Y, Maruhashi T, Iwamoto Y, Oda N, Kishimoto S, Matsui S, Hidaka T, Noma K, Nakashima A, Matsui T, Yamagishi S, Kihara Y
Organizer
American Heart Association Scientific Sessions 2017
Related Report
Int'l Joint Research
-
[Presentation] Endothelial function measured by enclosed zone flow-mediated vasodilation predicts cardiovascular events2017
Author(s)
Kajikawa M, Morimoto H, Oda N, Idei N, Hirano H, Maruhashi T, Kishimoto S, Matsui S, Hidaka T, Farina BMY, Kihara Y, Noma K, Nakashima A, Ukawa T, Tsuji T, Higashi Y
Organizer
American Heart Association Scientific Sessions 2017
Related Report
Int'l Joint Research
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[Presentation] Effect of Coffee with a High Content of Chlorogenic Acids and Low Content of Hydroxyhydroquinone on Postprandial Endothelial Dysfunction2017
Author(s)
Kajikawa M, Maruhashi T, Hidaka T, Nakano Y, Kurisu S, Matsumoto T, Iwamoto Y, Kishimoto S, Matsui S, Hashimoto H, Farina BMY, Kihara Y, Noma K, Nakashima A, Watanabe T, Tone H, Hibi M, Osaki N, Katsuragi Y, Higashi Y
Organizer
American Heart Association Scientific Sessions 2017
Related Report
Int'l Joint Research
-
[Presentation] Impaired endothelial function in patients receiving antihypertensive drug treatment regardless of achieved blood pressure level: FMD-J Study2017
Author(s)
Maruhashi T, Higashi Y, Kajikawa M, Iwamoto Y, Kishimoto S, Matsui S, Hashimoto H, Hidaka T, Noma K, Nakashima A, Kihara Y
Organizer
American Heart Association Scientific Sessions 2017
Related Report
Int'l Joint Research
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[Presentation] Short Term Colchicine Treatment Improves Endothelial Function in Patients with Cardiovascular Disease2017
Author(s)
Kajikawa M, Kurisu S, Maruhashi T, Hidaka T, Iwamoto Y, Kishimoto S, Matsui S, Hashimoto H, Farina BMY, Kihara Y, Noma K, Nakashima A, Matsushita A, Tomiyama H, Ueda S, Higashi Y
Organizer
American Heart Association Scientific Sessions 2017
Related Report
Int'l Joint Research
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[Presentation] Usefulness of Left atrial appendage wall velocity to predict left atrial spontaneous echo contrast in patients with severe aortic stenosis2017
Author(s)
Fukuda Y, Susawa H, Sumimoto Y, Kinoshita M, Itakura K, Masada K, Watanabe N, Ikenaga H, Utsunomiya H, Ishibashi K, Dohi Y, Hidaka T, Kurisu S, Kihara Y
Organizer
第81回日本循環器学会学術集会
Place of Presentation
石川県
Related Report
-
[Presentation] Variants Of Aldehyde Dehydrogenase 2 And Alcohol Dehydrogenase Genes Are Associated With Atrial Fibrillation2016
Author(s)
Nakano Y, Ochi H, Tomomori S, Matsumura H, Tokuyama T, Sairaku A, Motoda C, Chayama K, Chen C, Mochly-Rosen D, Kihara Y
Organizer
American Heart Association 2016
Place of Presentation
New Orleans,USA
Year and Date
2016-11-12
Related Report
Int'l Joint Research
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[Presentation] A Significant Correlation Between Nitroglycerine-induced Vasodilation in Coronary and Brachial Arteries2016
Author(s)
Maruhashi T, Higashi Y, Kajikawa M, Nakashima A, Iwamoto Y, Iwamoto A, Oda N, Kishimoto S, Matsui S, Higaki T, Shimonaga T, Watanabe N, Ikenaga H, Hidaka T, Aibara Y, Noma K, Kihara Y
Organizer
American Heart Association 2016
Place of Presentation
New Orleans,USA
Year and Date
2016-11-12
Related Report
Int'l Joint Research
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[Presentation] Risk Stratification of Ventricular Fibrillation in Brugada Syndrome Using Logistic Models of Noninvasive Parameters2016
Author(s)
Nakano Y, Kawazoe H, Ochi H, Takagi M, Tokuyama T, Sairaku A, Matsumura H, Tomomori S, Amioka M, Kihara Y
Organizer
American Heart Association 2016
Place of Presentation
New Orleans,USA
Year and Date
2016-11-12
Related Report
Int'l Joint Research
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[Presentation] Light to moderate alcohol consumption does not alter endothelial function2016
Author(s)
Oda N, Higashi Y, Maruhashi T, Kajikawa M, Kishimoto S, Matsui S, Iwamoto Y, Hidaka T, Nakashima A, Noma K, Tomiyama H, Takase B, Yamashina A, Kihara Y
Organizer
American Heart Association 2016
Place of Presentation
New Orleans,USA
Year and Date
2016-11-12
Related Report
Int'l Joint Research
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[Presentation] Vascular Smooth Muscle Function in Coronary and Brachial artery in Patients with Suspected Coroanry Artery Disease2016
Author(s)
Maruhashi T, Kajikawa M, Nakashima A, Iwamoto Y, Iwamoto A, Oda N, Kishimoto S, Matsui S, Noma K, Kihara Y, Higashi Y
Organizer
Pulse of Asia 2016 Seoul
Place of Presentation
Seoul,Korea
Year and Date
2016-09-24
Related Report
Int'l Joint Research
-
[Presentation] Impact of Triglycerides as Residual Risk for Cardiovascular Events on Endothelial Function: FMD-Japan Registry2016
Author(s)
Kajikawa M, Maruhashi T, Oda N, Kishimoto S, Matsui S, Hidaka T, Kihara Y, Noma K, Nakashima A, Tomiyama H, Takase B, Yamashina A, Higashi Y
Organizer
Pulse of Asia 2016 Seoul
Place of Presentation
Seoul,Korea
Year and Date
2016-09-24
Related Report
Int'l Joint Research
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[Presentation] Vascular Function and Rho-associated Kinase Activity in Patients with Idiopathic hyperaldosteronism2016
Author(s)
Kishimoto S, Higashi Y,Maruhashi T, Kajikawa M, Nakashima A, Iwamoto Y, Iwamoto A, Oda N, Matsui S, Hidaka T, Aibara Y, Noma K, Kihara Y
Organizer
Pulse of Asia 2016 Seoul
Place of Presentation
Seoul,Korea
Year and Date
2016-09-24
Related Report
Int'l Joint Research
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[Presentation] Endothelial Function Is Impaired in Subjects with Decreased Frequency and Duration of Tooth Brushing2016
Author(s)
Matsui S, Higashi Y, Kajikawa M, Maruhashi T, Iwamoto A, Oda N, Kishimoto S, Hidaka T, Aibara Y, Nakashima A, Noma K, Kihara Y
Organizer
Pulse of Asia 2016 Seoul
Place of Presentation
Seoul,Korea
Year and Date
2016-09-24
Related Report
Int'l Joint Research
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[Presentation] Long-term outcomes of patients treated with unplanned venoarterial extracorporeal membrane oxygenation2016
Author(s)
Kagawa E, Dote K, Kato M, Sasaki S, Oda N, Nakano Y, Nagai M, Yamane A, Kubo Y, Higashihara T, Miyauchi S, Kihara Y
Organizer
European Society of Cardiology 2016
Place of Presentation
Roma,Italy
Year and Date
2016-08-27
Related Report
Int'l Joint Research
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[Presentation] Gender Difference in the Influence of Baseline Brachial Artery Diameter on Flow mediated Vasodilation.2016
Author(s)
Maruhashi T, Higashi Y, Matsui S, Kishimoto S, Oda N, Iwamoto A, Kajikawa M, Iwamoto Y, Hidaka T, Nakashima A, Noma K, Takase B, Tomiyama H, Yamashina A, Kihara Y.
Organizer
第80回日本循環器学会学術集会
Place of Presentation
宮城県仙台市
Year and Date
2016-03-20
Related Report
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[Presentation] Vascular Function and Intima media Thickness of Leg Artery in Peripheral Artery Disease.2016
Author(s)
Iwamoto A, Higashi Y, Noma K, Nakashima A, Maruhashi T, Kajikawa M, Oda N, Kishimoto S, Iwamoto Y, Hidaka T, Kihara Y.
Organizer
第80回日本循環器学会学術集会
Place of Presentation
宮城県仙台市
Year and Date
2016-03-20
Related Report
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[Presentation] Why Some Patients Have Lone Severe Tricuspid Regurgitation without Other Valvular Diseases?2016
Author(s)
Itakura K, Hidaka T, Masada K, Kitagawa T, Suenari K, Dohi Y, Fukuda Y, Kurisu S, Nakano Y, Yamamoto H, Kihara Y.
Organizer
第80回日本循環器学会学術集会
Place of Presentation
宮城県仙台市
Year and Date
2016-03-20
Related Report
-
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[Presentation] The Evaluation of Pulmonary Vascular Resistance and Right Ventricular Function by Using Echocardiography.2016
Author(s)
Dohi Y, Uga S, Higashi A, Kinoshita H, Sada Y, Kitagawa T, Hidaka T, Suenari K, Noma K, Fukuda Y, Kurisu S, Nakano Y, Yamamoto H, Higashi Y, Kihara Y.
Organizer
第80回日本循環器学会学術集会
Place of Presentation
宮城県仙台市
Year and Date
2016-03-20
Related Report
-
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[Presentation] Extracorporeal Cardiopulmonary Resuscitation in Shockable or Nonshockable Rhythms.2016
Author(s)
Kagawa E, Dote K, Kato M, Sasaki S, Oda N, Nakano Y, Nagai M, Yamane A, Kubo Y, Higashihara T, Miyauchi S, Kihara Y.
Organizer
第80回日本循環器学会学術集会
Place of Presentation
宮城県仙台市
Year and Date
2016-03-20
Related Report
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[Presentation] Endothelial Function is Impaired in Subjects with Increased Serum Triglyceride Levels.2016
Author(s)
Kajikawa M, Higashi Y, Maruhashi T, Iwamoto Y, Iwamoto A, Oda N, Kishimoto S, Hidaka T, Nakashima A, Noma K, Tomiyama H, Takase B, Yamashina A, Kihara Y.
Organizer
第80回日本循環器学会学術集会
Place of Presentation
宮城県仙台市
Year and Date
2016-03-19
Related Report
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[Presentation] A Common Genetic Variant within SCN10A Modulates DNAMethylation of SCN5A Promoters.2016
Author(s)
Nakano Y, Ochi H, Tomomori S, Matsumura H, Kawazoe H, Tokuyama T, Sairaku A, Suenari K, Onohara Y, Chayama K, Kihara Y.
Organizer
第80回日本循環器学会学術集会
Place of Presentation
宮城県仙台市
Year and Date
2016-03-18
Related Report
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[Presentation] Vascular Function and Vascular Structure are Impaired in Patients with Heart Failure with Preserved Ejection Fraction.2016
Author(s)
Kishimoto S, Higashi Y, Oda N, Iwamoto A, Iwamoto Y, Kajikawa M, Maruhashi T, Hidaka T, Nakashima A, Noma K, Kihara Y.
Organizer
第80回日本循環器学会学術集会
Place of Presentation
宮城県仙台市
Year and Date
2016-03-18
Related Report
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[Presentation] Endothelial Function is Impaired in Relation to Alcohol Consumption in Men in a Large General Population.2015
Author(s)
Oda N, Higashi Y, Kajikawa M, Maruhashi T, Iwamoto A, Kishimoto S, Hidaka T, Nakashima A, Noma K, Tomiyama H, Takase B, Yamashina A, Kihara Y.
Organizer
The 88th Scientific Sessions of the American Heart Association 2015
Place of Presentation
Orlando,USA
Year and Date
2015-11-08
Related Report
Int'l Joint Research
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[Presentation] Endothelial Function is Impaired in Subjects With Increased Ratio of Serum Levels of AGEs to Soluble Form of RAGE.2015
Author(s)
Kajikawa M, Higashi Y, Nakashima A, Fujimura N, Maruhashi T, Iwamoto Y, Iwamoto A, Oda N, Kishimoto S, Hidaka T, Noma K, Takeuchi M, Matsui T, Yamagishi S, Kihara Y.
Organizer
The 88th Scientific Sessions of the American Heart Association 2015
Place of Presentation
Orlando,USA
Year and Date
2015-11-08
Related Report
Int'l Joint Research
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[Presentation] Increased Triglyceride Levels are Associated With Endothelial Dysfunction: FMD-Japan Registry.2015
Author(s)
Kajikawa M, Higashi Y, Maruhashi T, Iwamoto Y, Iwamoto A, Oda N, Kishimoto S, Hidaka T, Noma K, Tomiyama T, Takase B, Yamashina A, Kihara Y.
Organizer
The 88th Scientific Sessions of the American Heart Association 2015
Place of Presentation
Orlando,USA
Year and Date
2015-11-08
Related Report
Int'l Joint Research
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[Presentation] Vascular Function and Vascular Structure are impaired in Patients With Heart Failure With Preserved Ejection Fraction.2015
Author(s)
Kishimoto S, Higashi Y, Noma K, Nakashima A, Hidaka T, Maruhashi T, Kajikawa M, Iwamoto Y, Iwamoto A, Oda N, Aibara Y, Kihara Y.
Organizer
The 88th Scientific Sessions of the American Heart Association 2015
Place of Presentation
Orlando,USA
Year and Date
2015-11-08
Related Report
Int'l Joint Research
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[Presentation] Common Variant near HEY2 as a Protective Modifier of Ventricular Fibrillation in Brugada Syndrome.2015
Author(s)
Nakano Y, Ochi H, Toshishige M, Ikenaga H, Oda N, Tokuyama T, Sairaku A, Watanabe Y, Kawazoe H, Matsumura H, Tomomori S, Oda N, Kishimoto S, Uchimura-Makita Y, Motoda C, Fujiwara M, Kajihara K, Itakura K, Chayama K, Kihara Y.
Organizer
第79回日本循環器学会学術集会
Place of Presentation
大阪府大阪市
Year and Date
2015-04-24
Related Report
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[Presentation] Resting Periodic Breathing before Cardiopulmonary Exercise Testing was Strongly Correlated with Future Cardiovascular Events in Heart Failure Patients.2015
Author(s)
Kinoshita H, Dohi Y, Uga S, Higashi A, Sada Y, Tokuyama T, Maruhashi T, Kisaka T, Ishibashi K, Kitagawa T, Hidaka T, Fukuda Y, Kurisu S, Nakano Y, Yamamoto H, Kihara Y.
Organizer
第79回日本循環器学会学術集会
Place of Presentation
大阪府大阪市
Year and Date
2015-04-24
Related Report
-
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[Book] エビデンスに基づく 循環器看護ケア関連図2017
Author(s)
(執筆協力)石橋堅,宇都宮裕人,北川知郎,木原康樹,栗栖智,土肥由裕,德山丈仁,中野由紀子,日髙貴之,福田幸弘,丸橋達也
Total Pages
376
Publisher
中央法規出版(株)
Related Report
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[Book] 高齢心不全患者の治療に関するステートメント2016
Author(s)
安達仁,安斉俊久,猪又孝元,木原康樹,佐藤幸人,清野精彦,筒井裕之,原田和昌,福本義弘,増山理,百村伸一,弓野大,横山広行,吉川勉
Total Pages
55
Publisher
(一社)日本心不全学会
Related Report
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