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Investigation for clinical impact of serum Klotho level in tissue characterization of coronary artery plaque

Research Project

Project/Area Number 15K09087
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Cardiovascular medicine
Research InstitutionNagasaki University

Principal Investigator

KOGA Seiji  長崎大学, 病院(医学系), 助教 (00398158)

Co-Investigator(Kenkyū-buntansha) 池田 聡司  長崎大学, 医歯薬学総合研究科(医学系), 講師 (10336159)
前村 浩二  長崎大学, 医歯薬学総合研究科(医学系), 教授 (90282649)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords石灰化 / 冠動脈疾患 / 動脈硬化 / 血管内イメージング / 慢性腎臓病 / 冠動脈 / イメージング
Outline of Final Research Achievements

Klotho protein plays a crucial role in calcium/phosphate metabolism. However, physiological significance of serum α-Klotho has not yet been elucidated in detail. We analyzed coronary artery calcification in 75 patients with stable angina pectoris who underwent percutaneous coronary intervention following intravascular ultrasound (IVUS). The main outcome measure was the calcium index which was calculated from IVUS-derived total calcium length, lesion length, and maximal calcium arc. Serumα-Klotho levels correlated significantly and positively with estimated glomerular filtration rate (eGFR), and negatively with fibroblast growth factor 23 (FGF23) and calcium index. Multivariate regression analysis showed that serum α-Klotho was a significant independent factor associated with calcium index. In conclusion, an independent, inverse relationship was observed between serum α-Klotho level and coronary calcification in patients with stable angina pectoris.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (4 results)

All 2018 2016

All Presentation (4 results) (of which Int'l Joint Research: 1 results)

  • [Presentation] 血清α-Klotho値と冠動脈プラークの組織性状の関連:血管内超音波を用いた検討2018

    • Author(s)
      古賀 聖士、池田 聡司、室屋 隆弘、小出 優史、河野 浩章、前村 浩二
    • Organizer
      第47回日本心脈管作動物質学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Lower Serum Klotho Levels are Associated with Greater Calcified Components in Coronary Culprit Lesions Determined by iMap-intravascular Ultrasound2018

    • Author(s)
      Seiji Koga, Satoshi Ikeda, Tomoo Nakata, Tsuyoshi Yonekura, Toshiro Katayama, Yuji Koide, Hiroaki Kawano, Koji Maemura
    • Organizer
      第82回日本循環器学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Circulating soluble α-Klotho is inversely associated with coronary artery calcification evaluated by three-dimensional intravascular ultrasound2018

    • Author(s)
      Seiji Koga, Satoshi Ikeda, Ryohei Akashi, Yuki Yamagata, Tsuyoshi Yonekura, Takahiro Muroya, Yuji Koide, Hiroaki Kawano, Koji Maemura
    • Organizer
      ESC congress 2018
    • Related Report
      2017 Annual Research Report
  • [Presentation] Lower serum Klotho levels are associated with increased calcified components in coronary culprit lesions determined by iMap-intravascular ultrasound2016

    • Author(s)
      Seiji Koga, Satoshi Ikeda, Tomoo Nakata, Tsuyoshi Yonekura, Toshiro Katayama, Yuji Koide, Hiroaki Kawano, Koji Maemura
    • Organizer
      ESC congress 2016
    • Place of Presentation
      Fiera di Roma, Rome, Italy
    • Year and Date
      2016-08-27
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research

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Published: 2015-04-16   Modified: 2019-03-29  

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