Establishment of optimal antithrombotic therapy by using novel thrombus formation analysis system in patients with cardiovascular disease
Project/Area Number |
15K09089
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Cardiovascular medicine
|
Research Institution | Kumamoto University |
Principal Investigator |
KAIKITA Koichi 熊本大学, 大学院生命科学研究部(医), 准教授 (30346978)
|
Research Collaborator |
ISHII Masanobu 熊本大学, 医学教育部, 大学院生
|
Project Period (FY) |
2015-04-01 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
|
Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
Keywords | 循環器・高血圧 / 血栓形成能評価システム / 抗血栓療法 / 冠動脈疾患 / 心房細動 / 直接的経口抗凝固薬 / 新規経口抗凝固薬 / 血栓形成能測定システム |
Outline of Final Research Achievements |
First, we tested the utility of T-TAS in patients with coronary artery disease (CAD) with or without antiplatelet therapies. We measured PL-AUC levels by T-TAS in 372 patients who were divided into three groups; patients not on any antiplatelet therapy (control), on aspirin only, and on aspirin and clopidogrel. PL-AUC levels were significantly lower in two antiplatelet therapy groups compared with control group, and the level was significantly lower in the aspirin/clopidogrel group than aspirin group. Next, we evaluated the utility of T-TAS in predicting periprocedural bleeding in patients with atrial fibrillation (AF) undergoing catheter ablation (CA) by measuring AR-AUC levels on the day, 3 and 30 days post-CA. AR-AUC levels at the day of CA and 3 days post-CA was associated with periprocedural bleeding events, suggesting that AR-AUC level determined by T-TAS is a potentially useful marker for prediction of bleeding events in AF patients undergoing CA.
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Report
(4 results)
Research Products
(29 results)
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[Journal Article] Edoxaban Enhances Thromboprophylaxis by Physiotherapy After Total Knee Arthroplasty ― The Randomized Controlled ESCORT-TKA Trial ―2018
Author(s)
Sueta D, Kaikita K, Okamoto N, Yamabe S, Ishii M, Arima Y, Ito M, Oimatsu Y, Mitsuse T, Iwashita S, Nakamura E, Hokimoto S, Mizuta H, Ogawa H, Tsujita K
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Journal Title
Circulation Journal
Volume: 82
Issue: 2
Pages: 524-531
DOI
NAID
ISSN
1346-9843, 1347-4820
Related Report
Peer Reviewed
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[Journal Article] Total thrombus-formation analysis system predicts periprocedural bleeding events in patients with coronary artery disease undergoing percutaneous coronary intervention.2017
Author(s)
Oimatsu Y, Kaikita K, Ishii M, Mitsuse T, Ito M, Arima Y, Sueta D, Takahashi A, Iwashita S, Yamamoto E, Kojima S, Hokimoto S, Tsujita K.
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Journal Title
J Am Heart Assoc.
Volume: 6
Issue: 4
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Efficacy study of the combination of edoxaban and physiotherapy on the prevention of venous-thromboembolism in patients after total knee arthroplasty (ESCORT-TKA trial): study protocol for a randomized controlled trial.2016
Author(s)
Sueta D, Kaikita K, Okamoto N, Yamabe S, Ishii M, Arima Y, Ito M, Oimatsu Y, Iwashita S, Takahashi A, Sakamoto K, Tsujita K, Nakamura E, Hokimoto S, Mizuta H, Ogawa H
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Journal Title
Clin Trials Regul Sci Cardiol.
Volume: 19
Pages: 1-4
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Assessment of platelet-derived thrombogenicity by the total thrombus-formation analysis system in coronary artery disease patients on antiplatelet therapy.2016
Author(s)
Arima Y, Kaikita K, Ishii M, Ito M, Sueta D, Oimatsu Y, Sakamoto K, Tsujita K, Kojima S, Nakagawa K, Hokimoto S, Ogawa H.
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Journal Title
J Thromb Haemost.
Volume: 14
Issue: 4
Pages: 850-859
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Total thrombus-formation analysis system (T-TAS) can predict periprocedural bleeding events in patients undergoing catheter ablation for atrial fibrillation.2016
Author(s)
Ito M, Kaikita K, Sueta D, Ishii M, Oimatsu Y, Arima Y, Iwashita S, Takahashi A, Hoshiyama T, Kanazawa H, Sakamoto K, Yamamoto E, Tsujita K, Yamamuro M, Kojima S, Hokimoto S, Yamabe H, Ogawa H.
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Journal Title
J Am Heart Assoc.
Volume: 5
Issue: 1
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] A novel quantitative assessment of whole blood thrombogenicity in patients treated with a non-vitamin K oral anticoagulant.2015
Author(s)
Sueta D, Kaikita K, Okamoto N, Arima Y, Ishii M, Ito M, Oimatsu Y, Iwashita S, Takahashi A, Nakamura E, Hokimoto S, Mizuta H, Ogawa H.
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Journal Title
Int J Cardiol.
Volume: 197
Pages: 98-100
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Presentation] Optimal Predictors for Periprocedural Bleeding Events After Catheter Ablation for Atrial Fibrillation; Comparison of T-TAS and Plasma DOACs Concentration.2018
Author(s)
Ito M, Kaikita K, Sueta D, Ishii M, Oimatsu Y, Mitsuse T, Kiyama T, Arima Y, Kanazawa H, Kaneko S, Kanemaru Y, Takashio S, Izumiya Y, Yamabe H, Tsujita K,
Organizer
第82回日本循環器学会総会・学術集会, 2018.3.23‐25, 大阪
Related Report
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[Presentation] Combination of Two Different Microchips in T-TAS Predicts High Risk Patients with Periprocedural Bleeding Events after Percutaneous Coronary Intervention.2018
Author(s)
Oimatsu Y, Kaikita K, Ishii M, Mitsuse T, Ito M, Arima Y, Sueta D, Nakanishi N, Kanazawa H, Takashio S, Yamamoto E, Sakamoto K, Izumiya Y, Kojima S, Tusjita K.
Organizer
第82回日本循環器学会総会・学術集会, 2018.3.23‐25, 大阪
Related Report
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[Presentation] Total Thrombus-Formation Analysis System (T-TAS) Predicts 1-Year Bleeding Events in Patients with Coronary Artery Disease.2018
Author(s)
Mitsuse T, Kaikita K, Sueta D, Ishii M, Oimatsu Y, Arima Y, Yamamoto E, Kojima S, Yamabe H, Tsujita K
Organizer
第82回日本循環器学会総会・学術集会, 2018.3.23‐25, 大阪
Related Report
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[Presentation] Total Thrombus-formation Analysis System but not Plasma Concentration of Direct Oral Antico-agulants Predict Bleeding Events in Patients with Atrial Fibrillation.2017
Author(s)
Kaikita K, Ishii M, Ito M, Sueta D, Oimatsu Y, Arima Y, Yamamoto E, Tsujita K, Yamamuro M, Kojima S, Yamabe H, Hokimoto S.
Organizer
第81回日本循環器学会総会学術集会
Place of Presentation
金沢
Year and Date
2017-03-17
Related Report
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[Presentation] Total Thrombus-formation Analysis System (T-TAS) to Predict Atrial Fibrillation Recurrence after Catheter Ablation.2017
Author(s)
Ito M, Kaikita K, Sueta D, Ishii M, Oimatsu Y, Mitsuse T, Arima Y, Kanazawa H, Kaneko S, Kanemaru Y, Yamabe H, Hokimoto S.
Organizer
第81回日本循環器学会総会学術集会
Place of Presentation
金沢
Year and Date
2017-03-17
Related Report
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[Presentation] The Optimal Predictor of Periprocedural Bleeding in Patients Undergoing Catheter Ablation for Atrial Fibrillation.2017
Author(s)
Mitsuse T, Kaikita K, Oimatsu Y, Sueta D, Arima Y, Kanazawa H, Yamamoto E, Tsujita K, Yamamuro M, Kojima S, Yamaabe H, Hokimoto S, Ishii M.
Organizer
第81回日本循環器学会総会学術集会
Place of Presentation
金沢
Year and Date
2017-03-17
Related Report
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[Presentation] Total Thrombus-formation Analysis System Predicts Periprocedural Bleeding Events in Patients with Coronary Arterial Disease Undergoing Percutaneous Coronary Intervention.2017
Author(s)
Oimatsu Y, Kaikita K, Ishii M, Mitsuse T, Ito M, Arima Y, Sueta D, Ymamoto E, Tsujita K, Kojima S, Hokimoto S.
Organizer
第81回日本循環器学会総会学術集会
Place of Presentation
金沢
Year and Date
2017-03-17
Related Report
-
[Presentation] Optimal Predictors for Periprocedural Bleeding Events after Catheter Ablation for Atrial Fibrillation - Comparison of Total Thrombus-Formation Analysis System (T-TAS) and Plasma DOACs Concentration-.2017
Author(s)
Ito M, Kaikita K, Sueta D, Ishii M, Oimatsu Y, Mitsuse T, Arima Y, Kanazawa H, Kaneko S, Kanemaru Y, Kiyama T, Takashio S, Izumiya Y, Yamabe H, Tsujita K.
Organizer
American Heart Association Scientific Sessions 2017, 2017.11.11-15, Anaheim, California
Related Report
Int'l Joint Research
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[Presentation] Combination of Two Different Microchips in Total Thrombus-Formation Analysis System Predicts High Risk Patients With Periprocedural Bleeding Events Events After Percutaneous Coronary Intervention.2017
Author(s)
Oimatsu Y, Kaikita K, Ishii M, Mitsuse T, Ito M, Arima Y, Sueta D, Kanazawa H, Takashio S, Yamamoto E, Sakamoto K, Izumiya Y, Kojima S, Tsujita K.
Organizer
American Heart Association Scientific Sessions 2017, 2017.11.11-15, Anaheim, California
Related Report
Int'l Joint Research
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[Presentation] Differential Thrombus Formation with Anticoagulants on a Microchip Flow-Chamber System.2017
Author(s)
Ishii M, Kaikita K, Ito M, Sueta D, Oimatsu Y, Mitsuse T, Arima Y, Hoshiyama T, Kanazawa H, Yamamoto E, Yamamuro M, Kojima S, Hokimoto S, Yamabe H, Tsujita K.
Organizer
第39回日本血栓止血学会学術集会,2017.6.8-10,名古屋
Related Report
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[Presentation] Total Thrombus-formation Analysis System Predicts Poor Adherence to Anticoagulant in Patients Undergoing Catheter for A trial Fibrillation.2016
Author(s)
Ito M, Kaikita K, Sueta D, IshiiM, Oimatsu Y, Mitsuse T, Arima Y, Iwashita S, Takahashi A, Kanazawa H, Kaneko S, Kanemaru Y, Hokimoto S, Yamabe H, Ogawa H.
Organizer
American Heart Association Scientific Sessions 2016
Place of Presentation
New Orleans, Louisiana, U.S.A.
Year and Date
2016-11-12
Related Report
Int'l Joint Research
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[Presentation] Total Thrombus-Formation Analysis System Predicts the Recurrence After Catheter Ablation for Atrial Fibrillation2016
Author(s)
Ito M, Kaikita K, Sueta D, IshiiM, Oimatsu Y, Mitsuse T, Arima Y, Iwashita S, Takahashi A, Kanazawa H, Kaneko S, Kanemaru Y, Hokimoto S, Yamabe H, Ogawa H.
Organizer
American Heart Association Scientific Sessions 2016
Place of Presentation
New Orleans, Louisiana, U.S.A.
Year and Date
2016-11-12
Related Report
Int'l Joint Research
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[Presentation] Total Thrombus-formation Analysis System (T-TAS) Predicts Poor Prognosis in Patients Undergoing Follow-up Coronary Angiography After Prectaneous Coronary Intervention.2016
Author(s)
Oimatsu Y, Kaikita K, Ishii M, Mitsuse T, Ito M, Arima Y, Sueta D, Yamamoto E, Tsujita K, Kojima S, Hokimoto S.
Organizer
American Heart Association Scientific Sessions 2016
Place of Presentation
New Orleans, Louisiana, U.S.A.
Year and Date
2016-11-12
Related Report
Int'l Joint Research
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[Presentation] A Novel Flow-Chamber System for Quantitative Assessment of Whole Blood Thrombogenicity in Coronary Artery Disease Patients with Antiplatelet Therapies.2016
Author(s)
Arima Y, Kaikita K, Ishii M, Oimatsu Y, Ono T, Iwashita S, Ito M, Tsujita K, Sakamoto K, Yamamoto E, Tanaka T, Kojima S, Hokimoto S, Ogawa H.
Organizer
第80日本循環器学会総会・学術集会
Place of Presentation
仙台
Year and Date
2016-03-18
Related Report
-
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[Presentation] Total Thrombus-formation Analysis System (T-TAS) as a Potent Predictor for Periprocedural Bleeding Events in Patients Undergoing Ablation for Atrial Fibrillation.2016
Author(s)
Ito M, Kaikita K, Arima Y, Sueta D, Ishii M, Hoshiyama T, Kanazawa H, Sakamoto K, Yamamoto E, Tsujita K, Tanaka T, Yamamuro M, Kojima S, Hokimoto S, Yamabe H, Ogawa H.
Organizer
第80日本循環器学会総会・学術集会
Place of Presentation
仙台
Year and Date
2016-03-18
Related Report
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[Presentation] T-TAS Predicts CYP2C19 Poor Metabolizer and Prognosis in Patients Undergoing Percutaneous Coronary Intervention Treated with Dual Antiplatelet Therapy.2016
Author(s)
Oimatsu Y, Kaikita K, Ishii M, Ito M, Arima Y, Sueta D, Sakamoto K, Yamamoto E, Tsujita K, Kojima S, Hokimoto S, Ogawa H.
Organizer
第80日本循環器学会総会・学術集会
Place of Presentation
仙台
Year and Date
2016-03-18
Related Report
-
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[Presentation] Novel Quantitative Assessment Of Whole Blood Thrombogenicity In Patients Treated With Anticoagulants Undergoing Radiofrequency Catheter Ablation For Atrial Fibrillation.2015
Author(s)
Ito M, Kaikita K, Sueta D, IshiiM, Arima Y, Iwashita S, Takahashi A, Hoshiyama T, Kanazawa H, Sakamoto K, Yamamoto E, Tsujita K, Tanaka T, Yamamuro M, Kojima S, Hokimoto S, Yamabe H, Ogawa H.
Organizer
American Heart Association Scientific Sessions
Place of Presentation
Orlando, Florida、U.S.A.
Year and Date
2015-11-07
Related Report
Int'l Joint Research
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[Presentation] T-TAS, a Novel Flow-Chamber System of Thrombogenicity, is Useful for the Assessment of Clotting Ability in Patients Undergoing Elective PCI.2015
Author(s)
Arima Y, Kaikita K, Ono T, Iwashita S, Ito M, Ishii M, Tsujita K, Sakamoto K, Yamamoto E, Tanaka T, Kojima S, Hokimoto S, Ogawa H.
Organizer
第79日本循環器学会総会・学術集会
Place of Presentation
大阪
Year and Date
2015-04-24
Related Report
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[Presentation] Total Thrombus-formation Analysis System (T-TAS) Predicts Poor Metabolizers of CYP2C19 Loss-of-function Alleles in Patients Undergoing Elective Percutaneous Coronary Intervention.2015
Author(s)
Ishii M, Kaikita K, Arima Y, Ono T, Iwashita S, Ito M, Tsujita K, Sakamoto K, Kojima S, Hokimoto S, Ogawa H.
Organizer
第79日本循環器学会総会・学術集会
Place of Presentation
大阪
Year and Date
2015-04-24
Related Report