| Project/Area Number |
15K09089
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cardiovascular medicine
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| Research Institution | Kumamoto University |
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Principal Investigator |
KAIKITA Koichi 熊本大学, 大学院生命科学研究部(医), 准教授 (30346978)
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| Research Collaborator |
ISHII Masanobu 熊本大学, 医学教育部, 大学院生
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 循環器・高血圧 / 血栓形成能評価システム / 抗血栓療法 / 冠動脈疾患 / 心房細動 / 直接的経口抗凝固薬 / 新規経口抗凝固薬 / 血栓形成能測定システム |
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| Outline of Final Research Achievements |
First, we tested the utility of T-TAS in patients with coronary artery disease (CAD) with or without antiplatelet therapies. We measured PL-AUC levels by T-TAS in 372 patients who were divided into three groups; patients not on any antiplatelet therapy (control), on aspirin only, and on aspirin and clopidogrel. PL-AUC levels were significantly lower in two antiplatelet therapy groups compared with control group, and the level was significantly lower in the aspirin/clopidogrel group than aspirin group. Next, we evaluated the utility of T-TAS in predicting periprocedural bleeding in patients with atrial fibrillation (AF) undergoing catheter ablation (CA) by measuring AR-AUC levels on the day, 3 and 30 days post-CA. AR-AUC levels at the day of CA and 3 days post-CA was associated with periprocedural bleeding events, suggesting that AR-AUC level determined by T-TAS is a potentially useful marker for prediction of bleeding events in AF patients undergoing CA.
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