• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Relationship between heart failure and systemic inflammatory disease chronic obstructive pulmonary disease and clarification of vicious cycle factor

Research Project

Project/Area Number 15K09090
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Cardiovascular medicine
Research InstitutionFukushima Medical University

Principal Investigator

Atsushi Kobayashi  福島県立医科大学, 医学部, 助教 (20448640)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords心不全 / 慢性閉塞性肺疾患 / 全身性炎症疾患 / 肺高血圧症 / 悪液質
Outline of Final Research Achievements

Chronic obstructive pulmonary disease (COPD) has a great influence on cardiovascular diseases. It has been reported that the prognosis of heart failure patients is markedly reduced by the COPD, but there are many uncertainties about the details of the vicious circle. We examined the effects of COPD on cardiac function using samples obtained from patients with heart failure combined with COPD using echocardiography and biomarkers. We clarified that pulmonary hypertension is complicated irrespective of degree of respiratory dysfunction. In addition, since heart failure and COPD are frequent in elderly people and are often in cachectic state, we also examined the relationship with nutritional indicators and clarified the relevance.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (28 results)

All 2018 2017 2016 2015

All Journal Article (9 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 9 results,  Open Access: 8 results,  Acknowledgement Compliant: 1 results) Presentation (19 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Novel parameter to predict left ventricular filling pressure: product of log B-Type Natriuretic peptide and ratio of mitral inflow early and late diastolic filling velocities.2018

    • Author(s)
      Oikawa M, Kobayashi A, Wada K, Sato T, Suzuki S, Yoshihisa A, Nakazato K, Suzuki H, Saitoh S, Ishida T, Takeishi Y
    • Journal Title

      J Card Fail

      Volume: 24 Issue: 1 Pages: 29-32

    • DOI

      10.1016/j.cardfail.2017.10.008

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Subclinical hypothyroidism is associated with adverse prognosis in heart failure patients.2018

    • Author(s)
      Sato Y, Yoshihisa A, Kimishima Y, Kiko T, Watanabe S, Kanno Y, Abe S, Miyata M, Sato T, Suzuki S, Oikawa M, Kobayashi A, Yamaki T, Kunii H, Nakazato K, Ishida T, Takeishi Y
    • Journal Title

      Can J Cardiol

      Volume: 34 Issue: 1 Pages: 80-87

    • DOI

      10.1016/j.cjca.2017.10.021

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Associations between acylcarnitine to free carnitine ratio and adverse prognosis in heart failure patients with reduced or preserved ejection fraction.2018

    • Author(s)
      Yoshihisa A, Watanabe S, Yokokawa T, Misaka T, Sato T, Suzuki S, Oikawa M, Kobayashi A, Takeishi Y
    • Journal Title

      ESC Heart Failure

      Volume: 4 Issue: 3 Pages: 360-364

    • DOI

      10.1002/ehf2.12176

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Clinical features in extremely elderly patients with heart failure.2017

    • Author(s)
      Yokokawa T, Yoshihisa A, Kanno Y, Sato T, Suzuki S, Misaka T, Oikawa M, Kobayashi A, Yamaki T, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
    • Journal Title

      Geriatrics & Gerontology International

      Volume: 17 Issue: 11 Pages: 2194-2199

    • DOI

      10.1111/ggi.13060

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lotus Root Sign in the Renal Artery in Renovascular Hypertension2017

    • Author(s)
      Nakazato K, Kobayashi A, Nodera M, Kamioka M, Suzuki H, Saitoh S, Takeishi Y
    • Journal Title

      Circulation Journal

      Volume: 81 Issue: 8 Pages: 1234-1235

    • DOI

      10.1253/circj.CJ-17-0093

    • NAID

      130005859046

    • ISSN
      1346-9843, 1347-4820
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Familial hypertrophic obstructive cardiomyopathy with the GLA E66Q mutation and Zebra body2016

    • Author(s)
      Oikawa M, Sakamoto N, Kobayashi A, Suzuki A, Yoshihisa A. Yamaki T, Nakazato K, Suzuki H, Saitoh S, Kiko Y, Nakano H, Hayashi T, Kimura A, Takeishi Y
    • Journal Title

      BMC Cardiovasc Disord.

      Volume: 16 Issue: 1 Pages: 83-83

    • DOI

      10.1186/s12872-016-0262-y

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Impact of Peripheral Artery Disease on Prognosis in Hospitalized Heart Failure Patients2015

    • Author(s)
      Nakamura Y, Kunii H, Yoshihisa A, Takiguchi M, Shimizu T, Yamauchi H, Iwaya S, Owada T, Abe S, Sato T, Suzuki S, Oikawa M, Kobayashi A, Yamaki T, Sugimoto K, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
    • Journal Title

      Circulation Journal

      Volume: 79 Issue: 4 Pages: 785-793

    • DOI

      10.1253/circj.CJ-14-1280

    • NAID

      130005130257

    • ISSN
      1346-9843, 1347-4820
    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] ENDOGENOUS CARBON MONOXIDE CONCENTRATION IN BLOOD ELEVATES IN ACUTE CORONARY SYNDROME OF NONSMOKER POPULATION2015

    • Author(s)
      Kobayashi A, Mizukami H, Sakamoto N, Yamaki T, Kunii H, Nakazato K, Takeishi Y
    • Journal Title

      FUKUSHIMA JOURNAL OF MEDICAL SCIENCE

      Volume: 61 Issue: 1 Pages: 72-78

    • DOI

      10.5387/fms.2015-1

    • NAID

      130005087006

    • ISSN
      0016-2590, 2185-4610
    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Beneficial effects of positive airway pressure therapy for sleep-disordered breathing in heart failure patients with preserved left ventricular ejection fraction2015

    • Author(s)
      Yoshihisa A, Suzuki S, Yamauchi H, Sato T, Oikawa M, Kobayashi A, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
    • Journal Title

      Clinical Cardiology

      Volume: 38 Issue: 7 Pages: 413-421

    • DOI

      10.1002/clc.22412

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Associations between sigmoid septum and thoracic kyphosis in elderly populations2018

    • Author(s)
      小林 淳, 及川雅啓, 義久精臣, 中里和彦, 鈴木 均, 竹石恭知.
    • Organizer
      第82回 日本循環器学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Plasma BNP level is a strong parameter for detecting increased pulmonary capillary wedge pressure in patients with severe aortic stenosis.2017

    • Author(s)
      Masayoshi Oikawa, Atsushi Kobayashi, Akiomi Yoshihisa, Satoshi Suzuki, Takamasa Satoh, Takayoshi Yamaki, Hiroyuki Kunii, Kazuhiko Nakazato, Takafumi Ishida, Yasuchika Takeishi.
    • Organizer
      第81回 日本循環器学会学術集会
    • Place of Presentation
      金沢
    • Year and Date
      2017-03-17
    • Related Report
      2016 Research-status Report
  • [Presentation] 大動脈弁狭窄症に合併した軽度僧帽弁閉鎖不全症の大動脈弁置換術後の変化に関する検討2017

    • Author(s)
      小林 淳, 及川雅啓, 中里和彦, 鈴木 均, 斎藤修一, 竹石恭知.
    • Organizer
      第65回 日本心臓病学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 大動脈弁狭窄症におけるS字状中隔の大動脈弁置換術後弁機能に及ぼす影響の検討2017

    • Author(s)
      小林 淳, 及川雅啓, 中里和彦, 鈴木 均, 斎藤修一, 竹石恭知.
    • Organizer
      第28回 日本心エコー図学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Association between sleep disordered breathing and arterial stiffness in heart failure patients with reduced or preserved ejection fraction.2016

    • Author(s)
      Satoshi Suzuki, Akiomi Yoshihisa, Yu Sato, Tetsuro Yokokawa, Shunsuke Miura, Takamasa Sato, Shunsuke Watanabe, Masayoshi Oikawa, Atsushi Kobayashi, Takayoshi Yamaki, Hiroyuki Kunii, Kazuhiko Nakazato, Shu-ichi Saitoh, Yasuchika Takeishi.
    • Organizer
      Scientific Sessions of American Heart Association 2016
    • Place of Presentation
      New Orleans
    • Year and Date
      2016-11-12
    • Related Report
      2016 Research-status Report
  • [Presentation] Associations between acylcarnitine to total carnitine ratio and adverse prognosis in heart failure patients with reduced or preserved ejection fraction.2016

    • Author(s)
      Shunsuke Watanabe, Akiomi Yoshihisa, Yu Sato, Tetsuro Yokokawa, Shunsuke Miura, Takamasa Sato, Satoshi Suzuki, Masayoshi Oikawa, Atsushi Kobayashi, Takayoshi Yamaki, Hiroyuki Kunii, Kazuhiko Nakazato, Shu-ichi Saitoh, Yasuchika Takeishi.
    • Organizer
      Scientific Sessions of American Heart Association 2016
    • Place of Presentation
      New Orleans
    • Year and Date
      2016-11-12
    • Related Report
      2016 Research-status Report
  • [Presentation] The product of E/A and log BNP is a novel parameter to predict left ventricular filling pressure.2016

    • Author(s)
      Masayoshi Oikawa, Atsushi Kobayashi, Kento Wada, Takamasa Sato, Satoshi Suzuki, Akiomi Yoshihisa, Kazuhiko Nakazato, Shu-ichi Saitoh, Yasuchika Takeishi.
    • Organizer
      Scientific Sessions of American Heart Association 2016
    • Place of Presentation
      New Orleans
    • Year and Date
      2016-11-12
    • Related Report
      2016 Research-status Report
  • [Presentation] Paradoxical low-flow low-gradient aortic valve stenosis presented similar severity of heart failure to normal-flow high-gradient aortic valve stenosis.2016

    • Author(s)
      Masayoshi Oikawa, Atsushi Kobayashi, Akiomi Yoshihisa, Takayoshi Yamaki, Hiroyuki Kunii, Kazuhiko Nakazato, Hitoshi Suzuki, Shu-ichi Saitoh, Yasuchika Takeishi.
    • Organizer
      第20回 日本心不全学会学術集会
    • Place of Presentation
      札幌
    • Year and Date
      2016-10-07
    • Related Report
      2016 Research-status Report
  • [Presentation] Abdominal subcutaneous fat is associated with preclinical right ventricular diastolic dysfunction2016

    • Author(s)
      Oikawa M, Kobayashi A, Satoh T, Suzuki S, Yoshihisa A, Saitoh S, Takeishi Y
    • Organizer
      第80回 日本循環器学会学術集会
    • Place of Presentation
      仙台
    • Year and Date
      2016-03-18
    • Related Report
      2015 Research-status Report
  • [Presentation] The product value of E/E´ and E/A is a novel prognostic index in patients with non-ischemic cardiomyopathy2016

    • Author(s)
      Oikawa M, Kobayashi A, Yoshihisa A, Suzuki S, Satoh T, Sakamoto N, Yamaki T, Kunii H, Nakazato K, Saitoh S, Takeishi Y
    • Organizer
      第80回 日本循環器学会学術集会
    • Place of Presentation
      仙台
    • Year and Date
      2016-03-18
    • Related Report
      2015 Research-status Report
  • [Presentation] A case of takotsubo cardiomyopathy complicated by transient cataplectic attack of upper limb2015

    • Author(s)
      Akama J, Kobayashi A, Kimishima Y, Kaneshiro T, Sakamoto N, Sugimoto K, Suzuki H, Saitoh S, Takeishi Y
    • Organizer
      第19回 日本心不全学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2015-10-22
    • Related Report
      2015 Research-status Report
  • [Presentation] Association of insomnia with exercise capacity in heart failure patients2015

    • Author(s)
      Kanno Y, Yoshihisa A, Shimizu T, Takiguchi M, Yamauchi H, Sato T, Suzuki H, Oikawa M, Kobayashi A, Takeishi Y
    • Organizer
      第19回 日本心不全学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2015-10-22
    • Related Report
      2015 Research-status Report
  • [Presentation] Cardiac fabry disease presenting left ventricular outflow obstruction with E66Q mutation2015

    • Author(s)
      Oikawa M, Sakamoto N, Kobayashi A, Suzuki S, Yoshihisa A, Yamaki T, Saitoh S, Nakano H, Takeishi Y
    • Organizer
      第19回 日本心不全学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2015-10-22
    • Related Report
      2015 Research-status Report
  • [Presentation] Beneficial effects of positive airway pressure therapy for sleep-disordered breathing in heart failure patients with preserved left ventricular ejection fraction2015

    • Author(s)
      Yoshihisa A, Kanno Y, Shimizu T, Yamauchi H, Sato T, Suzuki S, Oikawa M, Kobayashi A, Saitoh S, Takeishi Y
    • Organizer
      第19回 日本心不全学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2015-10-22
    • Related Report
      2015 Research-status Report
  • [Presentation] Pseudonormal right ventricular filling pattern reflects left ventricular systolic dysfunction and remodeling2015

    • Author(s)
      Oikawa M, Kobayashi A, Yamauchi H, Suzuki S, Yoshihisa A, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
    • Organizer
      Congress of the European Society of Cardiology 2015
    • Place of Presentation
      London, UK
    • Year and Date
      2015-08-29
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] The usefulness of transtricuspid flow pattern to stratify the patients with impaired left ventricular diastolic function2015

    • Author(s)
      Oikawa M, Kobayashi A, Yamauchi H, Suzuki S, Yoshihisa A, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
    • Organizer
      第79回 日本循環器学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2015-04-24
    • Related Report
      2015 Research-status Report
  • [Presentation] Impact of hypocalcemia on mortality of patients with heart failure and chronic kidney disease2015

    • Author(s)
      Miura S, Yoshihisa A, Takiguchi M, Shimizu T, Nakamura Y, Yamauchi H, Owada T, Abe S, Suzuki S, Oikawa M, Kobayashi A, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
    • Organizer
      第79回 日本循環器学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2015-04-24
    • Related Report
      2015 Research-status Report
  • [Presentation] Impact of body mass index on mortality in heart failure patients2015

    • Author(s)
      Takiguchi M, Yoshihisa A, Miura S, Shimizu T, Nakamura Y, Yamauchi H, Owada T, Abe S, Suzuki S, Oikawa M, Kobayashi A, Sugimoto K, Yamaki T, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
    • Organizer
      第79回 日本循環器学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2015-04-24
    • Related Report
      2015 Research-status Report
  • [Presentation] Impact of insomnia on prognosis in hospitalized heart failure patients2015

    • Author(s)
      Takiguchi M, Yoshihisa A, Miura S, Shimizu T, Nakamura Y, Yamauchi H, Owada T, Abe S, Suzuki S, Oikawa M, Kobayashi A, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
    • Organizer
      第79回 日本循環器学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2015-04-24
    • Related Report
      2015 Research-status Report

URL: 

Published: 2015-04-16   Modified: 2019-03-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi