Impact of serum sulfatide level or micro RNA on coronary plaque vulnerability or restenosis post percutaneous coronary intervention
| Project/Area Number |
15K09094
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cardiovascular medicine
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| Research Institution | Dokkyo Medical University |
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Principal Investigator |
Taguchi Isao 獨協医科大学, 医学部, 教授 (80316570)
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| Co-Investigator(Kenkyū-buntansha) |
小松 孝昭 獨協医科大学, 医学部, 講師 (10597537)
井上 晃男 獨協医科大学, 医学部, 教授 (20168454)
中原 志朗 獨協医科大学, 医学部, 准教授 (70383081)
京ヶ島 守 日本薬科大学, 薬学部, 教授 (50225091)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 冠動脈疾患 / カテーテル治療 / 再狭窄 / プラーク / 冠動脈形成術 / micro RNA / スルファチド / 酸化ストレス |
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| Outline of Final Research Achievements |
The present study demonstrated that a balloon alone percutaneous coronary intervention (PCI) using drug coated balloon or ‘Stent-less PCI’ exhibited equivalent effects compared to PCI with drug eluting stents in coronary artery disease patients. After ‘Stent-less PCI’, anti-thrombotic agents can be reduced safely, because stent thrombosis or neo-atherosclerosis can be prevented. Therefore, coronary events and bleeding events will be prevented simultaneously and long term prognosis can be improved. In patients received ‘Stent-less PCI’ who plan to undergo non-cardiac surgeries, anti-thrombotic agents can be discontinued safely, and bleeding complications can be reduced. Additionally, when a patient after ‘Stent-less PCI’ will need coronary artery bypass grafting (CABG) in the future, there will be no coronary stent that might interfere in CABG.
‘Stent-less PCI’ should be performed in the patients whose coronary artery lesions can be dilated optimally only with balloon.
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Report
(4 results)
Research Products
(4 results)
