Biomarker establishment for novel cure therapy for dilated cardiomypathy
| Project/Area Number |
15K09096
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cardiovascular medicine
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| Research Institution | Tokyo Dental College (2016-2017)
Kitasato University (2015) |
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Principal Investigator |
Baba Akiyasu 東京歯科大学, 歯学部, 講師 (60296572)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 拡張型心筋症 / 重症心不全 / 免疫吸着療法 / アフェレシス / 心筋自己抗体 / バイオマーカー / 根治治療 / 自己抗体 / 治療 / 血漿交換 / カルニチン / 先進医療 / 治験 |
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| Outline of Final Research Achievements |
Immunoadsorption therapy is expected as a novel cure therapy for patients with dilated cardiomyopathy, so present study was performed in order to establish blood tests to efficiently treat those patients by this therapy. Autoantibodies against heart were measured in multiple ways using the blood of patients treated with “Advanced Medical Care B（MHLW）”. It was found that optimal treatment can be performed by measuring the autoantibody which could directly suppress heart function (Cardio-depressant autoantibody) before and after the immunoadsorption therapy against heart failure. Furthermore, it was also clarified that simple ELISA method can estimate the cardio-depressant autoantibody by simultaneously combining multiple autoantigens.
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Report
(4 results)
Research Products
(14 results)
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[Journal Article] Immunoadsorption therapy for dilated cardiomyopathy using tryptophan column-A prospective, multicenter, randomized, within-patient and parallel-group comparative study to evaluate efficacy and safety.2016
Author(s)
Yoshikawa T, Baba A, Akaishi M, Wakabayashi Y, Monkawa T, Kitakaze M, Izumi T, Tomoike H.
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Journal Title
J Clin Apher.
Volume: 31
Issue: 6
Pages: 141-150
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Very late-onset reversible cardiomyopathy in patients with chronic GvHD.2015
Author(s)
Kawano H, Tanaka H, Yamashita T, Hirata KI, Ishii S, Suzuki T, Wakahashi K, Kawano Y, Sada A, Minagawa K, Kawakami F, Itoh T, Baba A, Matsui T, Katayama Y.
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Journal Title
Bone Marrow Transplant.
Volume: 50
Issue: 6
Pages: 870-872
DOI
Related Report
Peer Reviewed / Open Access
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