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Establishment of noninvasive vulnerable plaque evaluation for clinical application

Research Project

Project/Area Number 15K09099
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Cardiovascular medicine
Research InstitutionJuntendo University

Principal Investigator

FUJIMOTO SHINICHIRO  順天堂大学, 医学部, 准教授 (70385871)

Research Collaborator Rybicki Frank J.  
KUMAMARU Kanako  
TAKAMURA Kazuhisa  
HIKI Makoto  
KAWAGUCHI Yuko  
KATO Etsuro  
AOSHIMA Chihiro  
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords冠動脈CT / 脆弱プラーク / プラーク解析 / クラスタリング解析 / Labeling法 / 心血管イベント予測 / 不安定プラーク
Outline of Final Research Achievements

As for the objective analysis accuracy of the new plaque analysis method (Labeling method) in coronary CT angiography, it was proved in actual cardiac tissues of the autopsy cases that the quantitative and objective plaque evaluation could be maintained even if the imaging conditions were changed. As for the analysis accuracy of clinical plaque morphology in actual clinical situation, it was compared as reference of OCT and NIRS-IVUS which are standard invasive analyses methods of plaque morphology and the better correlation was found with Labeling method rather than the Color map method used conventionally.
As for establishment of predictor of future cardiovascular events in Labeling method, because the number of registered cases was less than the scheduled number, the registration period has been prolonged. Coronary CT imaging scheduled two years later in this study was also started and the analyses of the usefulness of the events prediction in Labeling method has been started.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (7 results)

All 2018 2017 2016 2015

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 2 results) Presentation (5 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] Incremental prognostic value of coronary computed tomographic angiography high-risk plaque characteristics in newly symptomatic patients2016

    • Author(s)
      Fujimoto S, Kondo T, Takamura K, Baber U, Shinozaki T, Nishizaki Y, Kawaguchi Y, Matsumori R, Hiki M, Miyauchi K, Daida H, Hecht H, Stone GW, Narula J
    • Journal Title

      J Cardiol

      Volume: in press Issue: 6 Pages: 538-544

    • DOI

      10.1016/j.jjcc.2015.07.018

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prognostic Value of Coronary Computed Tomography (CT) Angiography and Coronary Artery Calcium Score Performed Before Revascularization.2015

    • Author(s)
      Fujimoto S, Kondo T, Kumamaru KK, Shinozaki T, Takamura K, Kawaguchi Y, Matsumori R, Hiki M, Miyauchi K, Daida H, Rybicki FJ.
    • Journal Title

      J Am Heart Assoc

      Volume: 4 Issue: 8

    • DOI

      10.1161/jaha.115.002264

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Usefulness of a novel plaque analysis software using a labeling method in low-tube voltage protocol2018

    • Author(s)
      Takamura K, Fujimoto S, Kato E, Kawaguchi Y, Aoshima C, Hiki M, Dohi T, Kumamaru K, Daida H.
    • Organizer
      The 82th Annual Scientific Meeting of the Japanese Circulation Society
    • Related Report
      2017 Annual Research Report
  • [Presentation] Usefulness of Novel Plaque Characteristics Analysis Software Employing the Labeling Method in Autopsy Cases2017

    • Author(s)
      Takamura K, Fujimoto S, Katou E, Kawaguchi Y,Hiki M, Kumamaru K, Daida H
    • Organizer
      The 81th Annual Scientific Meeting of the Japanese Circulation Society
    • Place of Presentation
      Kanazawa, Japan
    • Year and Date
      2017-03-17
    • Related Report
      2016 Research-status Report
  • [Presentation] Usefulness of New Plaque Characteristics Analysis Software Employing the Labeling Method for Autopsy Cases.2017

    • Author(s)
      Takamura K, Fujimoto S, Kawaguchi Y, Hiki M, Kato E, Aoshima C, Kumamaru K, Daida H.
    • Organizer
      SCCT 2017 12th Annual Scientific meeting,
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Incremental prognostic value of coronary computed tomographic angiography high risk plaque characteristics in asymptomatic patients2016

    • Author(s)
      Takamura K, Fujimoto S, Kondo T, Hiki M, Matsumori R, Kawaguchi Y, Suda S, Kato E, Kumamaru K, Takase S, Daida H.
    • Organizer
      The American College of Cardiology 65nd Annual Scientific Session
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2016-04-02
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Prognostic Value of Coronary CT Angiography and Coronary Artery Calcium Score Performed Before Revascularization2015

    • Author(s)
      Takamura: K, Fujimoto S, Kondo T, Kumamaru K, Kawaguchi Y, Suda S, Matsumori R., Kato E, Hiki M, Takase S, Rybicki FJ, Daida H
    • Organizer
      American Heart Association, 88th Scientific Session
    • Place of Presentation
      Orland, USA
    • Year and Date
      2015-11-07
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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