Establishment of noninvasive vulnerable plaque evaluation for clinical application
Project/Area Number |
15K09099
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Cardiovascular medicine
|
Research Institution | Juntendo University |
Principal Investigator |
|
Research Collaborator |
Rybicki Frank J.
KUMAMARU Kanako
TAKAMURA Kazuhisa
HIKI Makoto
KAWAGUCHI Yuko
KATO Etsuro
AOSHIMA Chihiro
|
Project Period (FY) |
2015-04-01 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
|
Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | 冠動脈CT / 脆弱プラーク / プラーク解析 / クラスタリング解析 / Labeling法 / 心血管イベント予測 / 不安定プラーク |
Outline of Final Research Achievements |
As for the objective analysis accuracy of the new plaque analysis method (Labeling method) in coronary CT angiography, it was proved in actual cardiac tissues of the autopsy cases that the quantitative and objective plaque evaluation could be maintained even if the imaging conditions were changed. As for the analysis accuracy of clinical plaque morphology in actual clinical situation, it was compared as reference of OCT and NIRS-IVUS which are standard invasive analyses methods of plaque morphology and the better correlation was found with Labeling method rather than the Color map method used conventionally. As for establishment of predictor of future cardiovascular events in Labeling method, because the number of registered cases was less than the scheduled number, the registration period has been prolonged. Coronary CT imaging scheduled two years later in this study was also started and the analyses of the usefulness of the events prediction in Labeling method has been started.
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Report
(4 results)
Research Products
(7 results)
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[Journal Article] Incremental prognostic value of coronary computed tomographic angiography high-risk plaque characteristics in newly symptomatic patients2016
Author(s)
Fujimoto S, Kondo T, Takamura K, Baber U, Shinozaki T, Nishizaki Y, Kawaguchi Y, Matsumori R, Hiki M, Miyauchi K, Daida H, Hecht H, Stone GW, Narula J
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Journal Title
J Cardiol
Volume: in press
Issue: 6
Pages: 538-544
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Prognostic Value of Coronary Computed Tomography (CT) Angiography and Coronary Artery Calcium Score Performed Before Revascularization.2015
Author(s)
Fujimoto S, Kondo T, Kumamaru KK, Shinozaki T, Takamura K, Kawaguchi Y, Matsumori R, Hiki M, Miyauchi K, Daida H, Rybicki FJ.
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Journal Title
J Am Heart Assoc
Volume: 4
Issue: 8
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Incremental prognostic value of coronary computed tomographic angiography high risk plaque characteristics in asymptomatic patients2016
Author(s)
Takamura K, Fujimoto S, Kondo T, Hiki M, Matsumori R, Kawaguchi Y, Suda S, Kato E, Kumamaru K, Takase S, Daida H.
Organizer
The American College of Cardiology 65nd Annual Scientific Session
Place of Presentation
Chicago, USA
Year and Date
2016-04-02
Related Report
Int'l Joint Research
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[Presentation] Prognostic Value of Coronary CT Angiography and Coronary Artery Calcium Score Performed Before Revascularization2015
Author(s)
Takamura: K, Fujimoto S, Kondo T, Kumamaru K, Kawaguchi Y, Suda S, Matsumori R., Kato E, Hiki M, Takase S, Rybicki FJ, Daida H
Organizer
American Heart Association, 88th Scientific Session
Place of Presentation
Orland, USA
Year and Date
2015-11-07
Related Report