Construction of Kanagawa-Acute cardiovascular registry - Measures for the prognosis improvement of acute severe myocardial infarction

• Project/Area Number: 15K09101
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular medicine
• Research Institution: Showa University
• Principal Investigator: Suzuki Hiroshi 昭和大学, 医学部, 教授 (90266106)
• Co-Investigator(Kenkyū-buntansha): 明石 嘉浩 聖マリアンナ医科大学, 医学部, 教授 (40350615) ; 阿古 潤哉 北里大学, 医学部, 教授 (60292744) ; 伊苅 裕二 東海大学, 医学部, 教授 (70271567) ; 佐藤 直樹 日本医科大学, 医学部, 教授 (70291721) ; 木村 一雄 横浜市立大学, 附属市民総合医療センター, 教授 (90214866)
• Co-Investigator(Renkei-kenkyūsha): EBINA Toshiaki 横浜市立大学, 医学部, 准教授 (60336568) ; MAEDA Atsuo 昭和大学, 医学部, 助教 (50439460)
• Research Collaborator: NAMIKI Atsuo
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2017: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000); Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2015: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 急性心筋梗塞 / 循環器救急疾患 / レジストリー研究 / 虚血性心疾患 / レジストリー

Outline of Final Research Achievements

We established Kanagawa-ACuTe cardIoVascular rEgistry (K-ACTIVE registry) to examine the current status of acute myocardial infarction (AMI), and to improve the treatment outcome of AMI in Kanagawa prefecture.
We enrolled approximately 3,200 AMI patients from October 2015 to March 2018. Mean age was 69 years old. ST-elevation MI was 76%. Although 58% of patients were directly transported to the percutaneous coronary intervention (PCI) capable hospital, 21% of the patients were transferred from PCI incapable to capable hospital. Onset to Door time was significantly longer in transfer group than in direct transport group. In terms of the recording of 12 leads prehospital ECG (PH12ECG), recorded group showed the significantly shorter Door to Cathelab time and First medical contact to Door time than non-recorded group. In-hospital mortality was 4.6%. In the future, recording of PH12ECG and the direct transport to the PCI capable hospital are important to improve the treatment outcome.

Research Products

• [Presentation] The latest sex-related differences and in-hospital mortality of ST-elevation myocardial infarction in Japan: Report from K-ACTIVE Registry (2018)
  • Author(s): Sakura Nagumo, Atsuo Maeda, Yoshihiro Akashi, Junya Ako, Yuji Ikari, Toshiaki Ebina, Naoki Sato, Atsuo Namiki, Kazuki Fukui, Ichiro Michishita, Kazuo Kimura, Hiroshi Suzuki
  • Organizer: 第82回日本循環器学会学術集会
• [Presentation] A study on present situation of Kanagawa-ACuTe cardIoVascular rEgistry (K-ACTIVE) (2018)
  • Author(s): 前田敦雄、明石嘉浩、阿古潤哉、伊苅裕二、海老名俊明、佐藤直樹、並木敦郎、福井和樹、道下一朗、木村一雄、鈴木洋
  • Organizer: 第82回日本循環器学会学術集会
• [Presentation] Is Treatment Course Different between Daytime and Nighttime in Patients with ST-elevation Myocardial Infarction? Report from K-ACTIVE Registry (2018)
  • Author(s): 田代一真、森敬善、前田敦雄、明石嘉浩、阿古潤哉、伊苅裕二、海老名俊明、佐藤直樹、並木淳郎、福井和樹、道下一朗、木村一雄、鈴木 洋
  • Organizer: 第82回日本循環器学会学術集会
• [Presentation] Diagnosis to Wire-crossing Time in Treatment of Patients with ST-elevation Myocardial Infarction: from K-ACTIVE registry (2018)
  • Author(s): 武井洋介、森敬善、前田敦雄、明石嘉浩、阿古潤哉、伊苅裕二、海老名俊明、佐藤直樹、並木淳郎、福井和樹、道下一朗、木村一雄、鈴木洋
  • Organizer: 第82回日本循環器学会学術集会
• [Presentation] Predictors of Selecting Transfemoral Intervention in Acute Myocardial Infarction -K-Active Registry- (2018)
  • Author(s): Kaoru Sakurai, koji Aszegami, Atsuo Maeda, Yoshihiro Akashi, Junya Ako, Yuji Ikari, Toshiaki Ebina, Kazuki Fukui, Ichiro Michishita, Kazuo Kimura, Hiroshi Suzuki
  • Organizer: 第82回日本循環器学会学術集会
• [Presentation] Clinical outcome about Elderly AMI patients from K-ACTIVE Registry (2018)
  • Author(s): Misa Ito, Kazuhiro Ashida, Kei Kawai, Atsuo Maeda, Yoshihiro Akashi, Junya Ako, Yuji Ikari, Toshiaki Ebina, Naoki Sato, Kazuki Fukui, Ichiro Michishita, Kazuo Kimura, Hiroshi Suzuki
  • Organizer: 第82回日本循環器学会学術集会
• [Presentation] A Study on Present Situation of Kanagawa-ACuTe Cardlo Vasucularr Egistry(K-ACTIVE) (2017)
  • Author(s): 前田敦雄
  • Organizer: The 81st Annual Scientific Meeting of the Japanese Circulation Society
  • Place of Presentation: 金沢
  • Year and Date: 2017-03-17
• [Presentation] 予後良好群と分類される急性心筋梗塞におけるTRIとTFIの比較 - K-Activeレジストリーより (2017)
  • Author(s): 櫻井 馨、畔上幸司、磯部光章、前田敦雄、明石嘉浩、阿古潤哉、伊苅裕二、海老名俊明、佐藤直樹、並木淳郎、福井和樹、道下一朗、木村一雄、鈴木 洋
  • Organizer: 第26回日本心血管インターベンション治療学会
• [Presentation] 神奈川レジストリーのデータから得られた若年者発症心筋梗塞の臨床的特徴について (2017)
  • Author(s): 山崎浩史、小徳のぞみ、田邊康宏、笠原みづほ、石橋祐記、茶谷健一、明石嘉浩、前田敦雄、木村一雄、鈴木 洋
  • Organizer: 第26回日本心血管インターベンション治療学会
• [Presentation] 神奈川循環器救急レジストリー（K-ACTIVE）からみる病院前心電図の効果 (2016)
  • Author(s): 佐藤伸洋、竹内一郎、及川 淳、佐藤孝典、水谷知泰、下浜孝郎、東條大輝、阿古潤哉、前田敦雄、鈴木 洋
  • Organizer: 第30回日本冠疾患学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2016-12-10
• [Presentation] 日本人急性心筋梗塞患者の予後予測におけるGrace scoreの有用性 (2016)
  • Author(s): 山崎浩史、田邉康宏、笠原みずほ、石橋祐記、茶谷健一、明石嘉浩、前田敦雄、鈴木 洋
  • Organizer: 第30回日本冠疾患学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2016-12-10
• [Remarks] K-ACTIVE 神奈川循環器救急レジストリー
  • URL: http://www.kactive.net/