| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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| Outline of Final Research Achievements |
To investigate the impact of obesity/metabolic syndrome on electrophysiologic and anatomical AF substrates, 15 dogs were divided into three groups. High-fat diet and rapid atrial pacing for 4-8 weeks (MetS-AF group, n=5), Rapid atrial pacing for 4-8 weeks with normal diet (AF group, n=5), and Noarmal diet without rapid atrial pacing (control group, n=5). Body weight was increased significantly in MetS-AF group than in AF and control groups. During electrophysiologic study, ERP of the left atrium (LA)/pulmonary veins (PVs) were shorter in MetS-AF group than AF group and control group. Histological examination showed extent of fatty infiltration with a small fibrotic change in epicardial LA increased in the MetS-AF group compared to AF and control groups. Shortening of LA/PVs-ERP was correlated with the extent of fatty infiltration. Our data suggest that fatty infiltration of the LA in the MetS-AF group plays an important role in the pathogenesis of AF.
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