Effect of metabolic syndrome on the remodeling and thrombosis formation of atrial fibrillation
Project/Area Number |
15K09104
|
Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Cardiovascular medicine
|
Research Institution | Nihon University |
Principal Investigator |
|
Project Period (FY) |
2015-04-01 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
|
Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
|
Keywords | メタボリック症候群 / 心房細動 / リモデリング / 血栓形成 / 脂肪浸潤 / 肥満 / 凝固線溶系因子 / 心房筋リモデリング |
Outline of Final Research Achievements |
To investigate the impact of obesity/metabolic syndrome on electrophysiologic and anatomical AF substrates, 15 dogs were divided into three groups. High-fat diet and rapid atrial pacing for 4-8 weeks (MetS-AF group, n=5), Rapid atrial pacing for 4-8 weeks with normal diet (AF group, n=5), and Noarmal diet without rapid atrial pacing (control group, n=5). Body weight was increased significantly in MetS-AF group than in AF and control groups. During electrophysiologic study, ERP of the left atrium (LA)/pulmonary veins (PVs) were shorter in MetS-AF group than AF group and control group. Histological examination showed extent of fatty infiltration with a small fibrotic change in epicardial LA increased in the MetS-AF group compared to AF and control groups. Shortening of LA/PVs-ERP was correlated with the extent of fatty infiltration. Our data suggest that fatty infiltration of the LA in the MetS-AF group plays an important role in the pathogenesis of AF.
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Report
(4 results)
Research Products
(6 results)
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[Journal Article] Clinical implications of serum adiponectin on progression of atrial fibrillation.2017
Author(s)
Yamaguchi N, Okumura Y, Watanabe I, Nagashima K, Takahashi K, Iso K, Watanabe R, Arai M, Kurokawa S, Ohkubo K, Nakai T, Hirayama A.
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Journal Title
Journal of Arrhythmia
Volume: 33(6)
Issue: 6
Pages: 608-612
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Presentation] Influence of Obesity on the Progression of Electrical and Structural Remodeling in a Canine Atrial Fibrillation Model2018
Author(s)
Masaru Arai, Ichiro Watanabe, Kouichi Ngashima, Kazuki Iso, Ryuta Watanabe, Yuji Wakamatsu, Sayaka Kurokawa, Kimie Ohkubo, Toshiko Nakai, Hiroyuki Hao, Rie Takahashi, Yoshiki Taniguchi, Mizuki Nikaido, Yasuo Okumura
Organizer
Heart Rhythm Scientific Sessions 2018, May 9-12, Boston
Related Report
Int'l Joint Research
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[Presentation] Importance of Epicardial Adipose Tissue on Reverse Atrial Remodeling After Atrial Fibrillation Ablation2018
Author(s)
Koyuru Monno, Yasuo Okumura, Saito Yuki, Aizawa Yoshihiro, Koichi Nagashima, Ryuta Watanabe, Masaru Arai, Yuji Wakamatsu, Ichiro Watanabe, Atsushi Hirayama
Organizer
The 82nd Annual Scientific Meeting of the Japanese Circulation Society, 2018
Related Report
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[Presentation] Impact of the body mass index on reverse atrial remodeling after atrial fibrillation ablation2017
Author(s)
Koyuru Monno, Yasuo Okumura, Yuki Saito, Yoshihiro Aizawa,Koichi Nagashima, Kazuki Iso, Kieko Takahashi, Masaru Arai, Ryuta Watanabe, Takafumi Hiro, Ichiro Watanabe, Atsushi Hirayama
Organizer
The 81st Annual Scientific Meeting of the Japanese Circulation Society, 2017
Related Report