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Identification of a new risk factor related to oxidative stress of vasospastic angina pectoris

Research Project

Project/Area Number 15K09105
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Cardiovascular medicine
Research InstitutionKanazawa Medical University

Principal Investigator

KAWAI Yasuyuki  金沢医科大学, 医学部, 准教授 (40324157)

Co-Investigator(Kenkyū-buntansha) 藤林 幸輔  金沢医科大学, 医学部, 助教 (10633323)
中西 宏明  順天堂大学, 医学部, 准教授 (90392274)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords冠攣縮 / グルタミン酸 / シスチン / 内皮機能障害 / 抗酸化ストレス / 冠攣縮性狭心症 / 酸化ストレス / 抗酸化作用 / 食後高血糖 / 冠動脈疾患
Outline of Final Research Achievements

We investigated whether glutamic acid could be a risk of vasospastic angina pectoris (VSAP). Ninety-two consecutive patients suspected of having VSAP. All patients were performed diagnostic coronary angiography and the intracoronary acetylcholine provocation test. Fifty-five patients were provocation test positive (VSAP group), and 37 patients were negative (Control group).
There were no significant differences between the two groups in the levels of glutamic acid. As it has been well known that smoking is one of the major risk factor of VSAP, we compared the levels of plasma glutamic acid in the non-smokers. In non-smoker patients, the levels of plasma glutamic acid in the VSAP group were significant higher than those in the control group.
Plasma glutamic acid was significantly higher in non-smoker patients with VSAP than in non-smoker control patients, suggesting that plasma glutamic acid could be a risk factor of VSAP in non-smokers and contribute to the development of VSAP.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (3 results)

All 2018 2017

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (2 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Diurnal glycemic fluctuation is associated with severity of coronary artery disease in prediabetic patients: Possible role of nitrotyrosine and glyceraldehyde-derived advanced glycation end products2017

    • Author(s)
      Watanabe M. Kawai Y, Kitayama M, Akao H, Motoyama A, Wakasa M, Saito R, Aoki H, Fujibayashi K, Tsuchiya T, Nakanishi H, Saito K, Takeuchi M, Kajinami K.
    • Journal Title

      Journal of Cardiology

      Volume: 69 Issue: 6 Pages: 625-631

    • DOI

      10.1016/j.dmpk.2016.09.002

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] Glutamic acid as a risk factor of vasospasm in non-smoker2018

    • Author(s)
      Minako Oda, Kousuke Fujibayashi, Minoru Wakasa, Yasuyuki Kawai, Kouji Kajinami
    • Organizer
      The 82th Annual Scientific Meeting of the Japanese Circulation Society
    • Related Report
      2017 Annual Research Report
  • [Presentation] Glycer-AGEs is associated with the severity of cardiac function of diabetic cardiomyopathy2017

    • Author(s)
      Yuushi Yasuda, Wataru Fujita, Kousuke Fujibayashi, Minoru Wakasa, Yasuyuki Kawai, Katuaki Sato, Masayoshi Takeuchi, Hiroaki Nakanishi, Koji Kajinami
    • Organizer
      ESC congress 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research

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Published: 2015-04-16   Modified: 2019-03-29  

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