Investigation of the possible involvement of varicella-herpes zoster virus in cardiac sarcoidosis
| Project/Area Number |
15K09107
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cardiovascular medicine
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| Research Institution | Osaka Medical College |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
石坂 信和 大阪医科大学, 医学部, 教授 (20270879)
藤田 修一 大阪医科大学, 医学部, 講師 (80722628)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | サルコイドーシス / 病因 / 帯状疱疹 / Propionibacterium acnes / 網羅的検索 / 心臓サルコイドーシス / 心筋症 / 18F-FDG PET / 炎症 / リンパ節 / ウイルス / 細菌 / PCR法 / 水痘・帯状疱疹ウイルス / 免疫組織化学 / 単純ヘルペスウイルス |
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| Outline of Final Research Achievements |
In this study, serological, pathophysiological, and molecular biological studies were performed to investigate the possible involvement of varicella-herpes zoster virus (VZV) and Propionibacterium acnes (P. acnes). Comprehensive analyses of granuloma tissues for the presence of 174 different viruses and 75 bacteria/fungi revealed no genes of these pathogens in the tissues . These findings suggest that active pathogens such as VZV and P. acnes are unlikely to be present in granuloma in patients with sarcoidosis.
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Report
(4 results)
Research Products
(34 results)
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[Book] 内科学2017
Author(s)
寺﨑文生 他
Total Pages
2385
Publisher
朝倉書店
Related Report
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