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Investigation of the possible involvement of varicella-herpes zoster virus in cardiac sarcoidosis

Research Project

Project/Area Number 15K09107
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Cardiovascular medicine
Research InstitutionOsaka Medical College

Principal Investigator

TERASAKI FUMIO  大阪医科大学, 医学部, 教授 (20236988)

Co-Investigator(Kenkyū-buntansha) 石坂 信和  大阪医科大学, 医学部, 教授 (20270879)
藤田 修一  大阪医科大学, 医学部, 講師 (80722628)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywordsサルコイドーシス / 病因 / 帯状疱疹 / Propionibacterium acnes / 網羅的検索 / 心臓サルコイドーシス / 心筋症 / 18F-FDG PET / 炎症 / リンパ節 / ウイルス / 細菌 / PCR法 / 水痘・帯状疱疹ウイルス / 免疫組織化学 / 単純ヘルペスウイルス
Outline of Final Research Achievements

In this study, serological, pathophysiological, and molecular biological studies were performed to investigate the possible involvement of varicella-herpes zoster virus (VZV) and Propionibacterium acnes (P. acnes). Comprehensive analyses of granuloma tissues for the presence of 174 different viruses and 75 bacteria/fungi revealed no genes of these pathogens in the tissues . These findings suggest that active pathogens such as VZV and P. acnes are unlikely to be present in granuloma in patients with sarcoidosis.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (34 results)

All 2018 2017 2016 2015

All Journal Article (19 results) (of which Peer Reviewed: 6 results,  Open Access: 4 results) Presentation (13 results) (of which Invited: 4 results) Book (2 results)

  • [Journal Article] Spontaneous Reduction in Abnormal Myocardial Uptake of Fluorine-18 Fluorodeoxygluose in a Patient with Cardiac Sarcoidosis2018

    • Author(s)
      Terasaki F, Fujita SI, Kanzaki Y, Hirose Y, Ishizaka N.
    • Journal Title

      International Heart Journal

      Volume: 59 Issue: 3 Pages: 647-651

    • DOI

      10.1536/ihj.17-315

    • NAID

      130007378352

    • ISSN
      1349-2365, 1349-3299
    • Year and Date
      2018-05-31
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] New Guidelines for Diagnosis of Cardiac Sarcoidosis in Japan2017

    • Author(s)
      Terasaki F, Yoshinaga K
    • Journal Title

      Annals of Nuclear Cardiology

      Volume: 3 Issue: 1 Pages: 42-45

    • DOI

      10.17996/anc.17-00042

    • NAID

      130006191150

    • ISSN
      2189-3926, 2424-1741
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A comprehensive search for microbial DNA and RNA in sarcoidosis tissue samples by quantitative polymerase chain reaction.2017

    • Author(s)
      Terasaki F, Fukumoto H, Kawata R, Hirose Y, Fujita SI, Katano H, Ishizaka N.
    • Journal Title

      Infect Dis (Lond).

      Volume: 49(8) Issue: 8 Pages: 625-7

    • DOI

      10.1080/23744235.2017.1294259

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 胸部X線検査で肺門部腫脹を指摘された50歳代女性.2017

    • Author(s)
      伊藤隆英、寺﨑文生、石坂信和
    • Journal Title

      New専門医を目指すケース・メソッド・アプローチ循環器疾患第3版

      Volume: - Pages: 191-201

    • Related Report
      2017 Annual Research Report
  • [Journal Article] 心臓サルコイドーシス.2017

    • Author(s)
      寺﨑文生、藤田修一、石坂信和
    • Journal Title

      循環器診療ザ・ベーシック 心筋症.

      Volume: - Pages: 54-79

    • NAID

      40019366993

    • Related Report
      2017 Annual Research Report
  • [Journal Article] 薬物療法:サルコイドーシスの診断から治療まで.2017

    • Author(s)
      寺﨑文生、山口哲生、石坂信和
    • Journal Title

      Heart View

      Volume: 21(9) Pages: 973-80

    • Related Report
      2017 Annual Research Report
  • [Journal Article] 心臓サルコイドーシスの新しいガイドライン2017

    • Author(s)
      寺﨑文生
    • Journal Title

      心臓

      Volume: 49(7) Pages: 642-8

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 心臓サルコイドーシスの臨床像と新しい診断基準2017

    • Author(s)
      伊藤隆英、寺﨑文生、石坂信和
    • Journal Title

      臨床画像

      Volume: 33(1) Pages: 16-25

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
  • [Journal Article] あらたな心臓サルコイドーシス診療ガイドラインの概要2017

    • Author(s)
      寺﨑文生
    • Journal Title

      医学のあゆみ

      Volume: 260(4) Pages: 269-74

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
  • [Journal Article] 7-13心筋疾患2)その他の心筋症2017

    • Author(s)
      寺﨑文生
    • Journal Title

      内科学

      Volume: 11 Pages: 627-34

    • Related Report
      2017 Annual Research Report
  • [Journal Article] 7-13心筋疾患4)心臓腫瘍2017

    • Author(s)
      寺﨑文生
    • Journal Title

      内科学

      Volume: 11 Pages: 638-41

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Reversal of cardiac remodeling after treatment of IgG4 related cholangitis - Possibility of IgG4-related heart disease?2016

    • Author(s)
      Terasaki F, Ishizaka N.
    • Journal Title

      Int J Cardiol.

      Volume: 223 Pages: 477-8

    • DOI

      10.1016/j.ijcard.2016.08.256

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] 心臓サルコイドーシスの診断はどのような手順で行うのか2016

    • Author(s)
      寺﨑文生
    • Journal Title

      Heart View

      Volume: 20(13) Pages: 1142-9

    • Related Report
      2016 Research-status Report
  • [Journal Article] サルコイドーシスや膠原病に伴う心筋症をどう診断するか2016

    • Author(s)
      伊藤隆英, 寺﨑文生, 石坂信和
    • Journal Title

      呼吸と循環

      Volume: 64(7) Pages: 688-96

    • Related Report
      2016 Research-status Report
  • [Journal Article] 心臓サルコイドーシスの免疫抑制療法をめぐって2016

    • Author(s)
      坂根和志, 藤田修一, 寺﨑文生, 石坂信和
    • Journal Title

      呼吸器内科

      Volume: 29(4) Pages: 313-8

    • NAID

      40020834361

    • Related Report
      2016 Research-status Report
  • [Journal Article] Cardiac Sarcoidosis and Arrhythmogenic Right Ventricular Cardiomyopathy -Potential Differential Diagnoses for Arrhythmogenic Ventricular Cardiomyopathy2016

    • Author(s)
      Terasaki F, Ishizaka N.
    • Journal Title

      Internal Medicine

      Volume: 55 Issue: 9 Pages: 1041-1042

    • DOI

      10.2169/internalmedicine.55.6422

    • NAID

      130005149595

    • ISSN
      0918-2918, 1349-7235
    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 心臓サルコイドーシスの免疫抑制療法をめぐって2016

    • Author(s)
      坂根和志, 藤田修一, 寺﨑文生, 石坂信和.
    • Journal Title

      呼吸器内科

      Volume: 29 Pages: 313-318

    • NAID

      40020834361

    • Related Report
      2015 Research-status Report
  • [Journal Article] 心臓サルコイドーシスの診断2015

    • Author(s)
      寺﨑文生
    • Journal Title

      呼吸と循環

      Volume: 63 Pages: 899-904

    • Related Report
      2015 Research-status Report
  • [Journal Article] 心臓限局性サルコイドーシス2015

    • Author(s)
      寺﨑文生, 藤田修一, 石坂信和.
    • Journal Title

      循環器内科

      Volume: 78 Pages: 342-348

    • Related Report
      2015 Research-status Report
  • [Presentation] 心臓サルコイドーシスの診療ガイドライン 1. 心臓サルコイドーシスの診断指針2017

    • Author(s)
      寺﨑文生
    • Organizer
      第81回日本循環器学会学術集会
    • Place of Presentation
      金沢都ホテル
    • Year and Date
      2017-03-17
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] 新たな診断指針に基づいた心臓サルコイドーシス診断の現状2017

    • Author(s)
      寺﨑文生、藤田修一、石坂信和
    • Organizer
      第65回日本心臓病学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 新しいサルコイドーシスの診断基準2017

    • Author(s)
      寺﨑文生
    • Organizer
      第65回日本心臓病学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 心臓サルコイドーシスの診療ガイドライン2017

    • Author(s)
      寺﨑文生
    • Organizer
      第81回日本循環器学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Cardiac Sarcoidosis-Update2017

    • Author(s)
      寺﨑文生
    • Organizer
      第81回日本循環器学会学術集会
    • Related Report
      2017 Annual Research Report 2016 Research-status Report
  • [Presentation] 新ガイドラインに学ぶ心サルコイドーシスの診断と治療心臓サルコイドーシスの診療ガイドラインーOverview―2017

    • Author(s)
      寺﨑文生
    • Organizer
      第3回日本心筋症研究会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 18F-FDG PET 陰性の心筋症の一例2017

    • Author(s)
      藤田修一、寺﨑文生、坂根和志、伊藤隆英、石坂信和
    • Organizer
      第3回日本心筋症研究会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 心臓サルコイドーシスの診療ガイドライン2016

    • Author(s)
      寺﨑文生
    • Organizer
      第20回日本心不全学会学術集会
    • Place of Presentation
      ロイトン札幌
    • Year and Date
      2016-10-07
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] ~サルコイドーシスに伴う心不全に関する多角的アプローチ~心サルコイドーシスガイドラインから見た診断とマネジメント2016

    • Author(s)
      寺﨑文生
    • Organizer
      第64回日本心臓病学会学術集会
    • Place of Presentation
      東京国際フォーラム
    • Year and Date
      2016-09-23
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] 心臓サルコイドーシスの診療をめぐる諸問題2016

    • Author(s)
      寺﨑文生
    • Organizer
      第108回日本循環器学会中国・四国合同地方会
    • Place of Presentation
      くにびきメッセ
    • Year and Date
      2016-06-11
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] 臨床的に心臓限局性サルコイドーシスと診断した2例2016

    • Author(s)
      藤田修一、山内洋平、坂根和志、神﨑裕美子、森田英晃、伊藤隆英、宗宮浩一、星賀正明、寺﨑文生、石坂信和
    • Organizer
      第2回心筋症研究会
    • Place of Presentation
      松本市まつもと市民芸術館(長野県松本市)
    • Year and Date
      2016-05-14
    • Related Report
      2015 Research-status Report
  • [Presentation] 心臓サルコイドーシスの診療ガイドライン2016

    • Author(s)
      寺﨑文生
    • Organizer
      第80回日本循環器学会学術集会
    • Place of Presentation
      東北大学百周年記念会館(宮城県仙台市)
    • Year and Date
      2016-03-18
    • Related Report
      2015 Research-status Report
  • [Presentation] 心臓サルコイドーシスの治療-Overview-2015

    • Author(s)
      寺﨑文生
    • Organizer
      第19回日本心不全学会学術集会
    • Place of Presentation
      グランフロント大阪、ナレッジキャピタル、コングレコンベンションセンター(大阪府大阪市)
    • Year and Date
      2015-10-22
    • Related Report
      2015 Research-status Report
  • [Book] 内科学2017

    • Author(s)
      寺﨑文生 他
    • Total Pages
      2385
    • Publisher
      朝倉書店
    • Related Report
      2016 Research-status Report
  • [Book] 診断モダリティとしての心筋病理2017

    • Author(s)
      寺﨑文生 他
    • Total Pages
      214
    • Publisher
      南江堂
    • Related Report
      2016 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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