| Project/Area Number |
15K09113
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cardiovascular medicine
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| Research Institution | National Cardiovascular Center Research Institute |
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Principal Investigator |
Inagaki Masashi 国立研究開発法人国立循環器病研究センター, 研究所, 室長 (80359273)
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| Co-Investigator(Renkei-kenkyūsha) |
LI Meihua 独立行政法人国立循環器病研究センター, 研究所, 特任研究員 (60443496)
KAWADA Toru 独立行政法人国立循環器病研究センター, 研究所, 室長 (30243752)
UEMURA Kazunori 独立行政法人国立循環器病研究センター, 研究所, 室長 (10344350)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Keywords | 心筋梗塞 / 心不全 / 自律神経 / 臨床心臓学 / 迷走神経 / 不整脈 |
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| Outline of Final Research Achievements |
The worldwide prevalence of heart failure that is the final pathway for various cardiovascular diseases is rising with the aging populations, a growing incidence of obesity, and significant healthcare improvements. Myocardial infarction is the most common underlying disease of heart failure, and it has been an important issue how the onset of heart failure is prevented after myocardial infarction. The aim of this study was to establish the short-term vagus nerve stimulation therapy after reperfusion therapy for acute myocardial infarction.
We established new experimental ischemia-reperfusion models which enable us to induce homogeneous ischemic region in rabbits and dogs. Percutaneous transluminal short-term (3days) vagus nerve stimulation after reperfusion therapy reduced myocardial infarction size.
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