Non-invasive coronary plaque imaging using quantitative magnetic resonance imaging and positron emission tomography

• Project/Area Number: 15K09114
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular medicine
• Research Institution: National Cardiovascular Center Research Institute
• Principal Investigator: Noguchi Teruo 国立研究開発法人国立循環器病研究センター, 病院, 部長 (70505099)
• Co-Investigator(Kenkyū-buntansha): 安田 聡 国立研究開発法人国立循環器病研究センター, 病院, 副院長 (00431578) ; 浅海 泰栄 国立研究開発法人国立循環器病研究センター, 病院, 医長 (20629315) ; 飯田 秀博 国立研究開発法人国立循環器病研究センター, 病院, 非常勤研究員 (30322720) ; 中尾 一泰 国立研究開発法人国立循環器病研究センター, 病院, 医師 (40730619)
• Project Period (FY): 2015-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: プラーク / 冠動脈 / MRI / 画像診断 / 不安定プラーク / 冠動脈プラーク / 動脈硬化 / MRI画像

Outline of Final Research Achievements

Coronary high-signal-intensity plaques (HIPs) detected by T1-weighted magnetic resonance imaging are associated with future cardiovascular events. We demonstrated that a standardized cardiac magnetic resonance imaging protocol for detecting coronary high-risk plaque using non-contrast T1-weighted imaging. In addition, we identified pathological findings reflecting HIPs in coronary arteries obtained from autopsy cases. As a result, coronary HIPs may reflect intraplaque hemorrhage and may be a novel marker for plaque instability and thrombogenic potential. Moreover, we performed to assess the anti-atherogenic effect of EPA/DHA in an exploratory manner to examine the change in signal-intensity of coronary HIPs after 12 months of EPA/DHA therapy (the AQUAMARINE EPA/DHA study)

Academic Significance and Societal Importance of the Research Achievements

1)冠動脈高信号プラーク（HIP）描出に最適な非造影T1強調法の標準撮像プロトコルを作成した。2）冠動脈HIPを有する虚血性心疾患患者を対象に、中性脂肪を低下させるEPA/DHA製剤を服用させることによってHIPの信号強度が変化するかを観察する前向き薬剤介入研究を終了した（2019年に成果発表）。3）ヒト剖検心を用いたMRIと組織標本の対比を行い、冠動脈HIPは粥腫内出血であることを確認した。

Research Products

• [Journal Article] Coronary high-signal-intensity plaques on T(1)-weighted magnetic resonance imaging reflect intraplaque hemorrhage (2019)
  • Author(s): Kuroiwa Y, Uchida A, Yamashita A, Miyati T, Maekawa K, Gi T, Noguchi T, Yasuda S, Imamura T, Asada Y
  • Journal Title: Cardiovasc Pathol Volume: 40 Pages: 24-31
  • DOI: 10.1016/j.carpath.2019.01.002
  • Peer Reviewed / Open Access
• [Journal Article] Effect of eicosapentaenoic acid/docosahexaenoic acid on coronary high-intensity plaques detected with non-contrast T1-weighted imaging (the AQUAMARINE EPA/DHA study): study protocol for a randomized controlled trial. (2018)
  • Author(s): Nakao K, Noguchi T, Asaumi Y, Morita Y, Kanaya T, et al.
  • Journal Title: Trials Volume: 19 Issue: 1 Pages: 12-12
  • DOI: 10.1186/s13063-017-2353-1
  • Peer Reviewed / Open Access
• [Journal Article] Optical coherence tomography-verified morphological correlates of high-intensity coronary plaques on non-contrast T1-weighted magnetic resonance imaging in patients with stable coronary artery disease. (2018)
  • Author(s): Kanaya T, Noguchi T, Otsuka F, Asaumi Y, Kataoka Y, Morita Y, Miura H, Nakao K, Fujino M, Kawasaki T, Nishimura K, Inoue T, Narula J, Yasuda S.
  • Journal Title: Eur Heart J Cardiovasc Imaging Volume: 00 Issue: 1 Pages: 1-1
  • DOI: 10.1093/ehjci/jey035
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Noninvasive Coronary Plaque Imaging (2018)
  • Author(s): Noguchi T, Nakao K, Asaumi Y, Morita Y, Otsuka F, Kataoka Y, Hosoda H, Miura H, Fukuda T, Yasuda S
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 25 Issue: 4 Pages: 281-293
  • DOI: 10.5551/jat.RV17019
  • NAID: 130006602384
  • ISSN: 1340-3478, 1880-3873
  • Peer Reviewed / Open Access
• [Journal Article] 8.Prognostic Impact of Spontaneous Coronary Artery Dissection in Young Female Patients with Acute Myocardial Infarction: Report from the Angina Pectoris-Myocardial Infarction Multicenter Investigators in Japan. (2016)
  • Author(s): Nakashima T, Noguchi T, Haruta S, Yamamoto Y, Oshima S, Nakao K, Taniguchi Y, Yamaguchi J, Tsuchihashi K, Seki A, Kawasaki T, Uchida T, Omura N, Kikuchi M, Kimura K, Ogawa H, Miyazaki S, Yasuda S.
  • Journal Title: International Journal of Cardiology Volume: 14 Pages: 341-341
  • DOI: 10.1016/j.ijcard.2016.01.188
  • Peer Reviewed / Open Access
• [Journal Article] .Effect of Intensive Statin Therapy on Coronary High-intensity Plaques Detected by Non-contrast T1-Weighted Imaging: the AQUAMARINE Pilot Study. (2015)
  • Author(s): Noguchi T, Tanaka A, Goto Y, Morita Y, Asaumi Y, Nakao Y, Fujiwara R, Nishimura K, Miyamoto Y, Ishhara M, Ogawa H, Koga N, Narula J, Yasuda S.
  • Journal Title: J Am Coll Cardiol Volume: 66 Issue: 3 Pages: 245-256
  • DOI: 10.1016/j.jacc.2015.05.056
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Prevalence, clinical features, and prognosis of acute myocardial infarction due to coronary artery embolism (2015)
  • Author(s): Noguchi T, Tanaka T, Asaumi Y, Kanaya T, Nagai T, Nakao K, Fujino M, Nagatsuka K, Ishibashi-Ueda H, Nishimura K, Miyamoto Y, Kusano K, Anzai, T, Goto Y, Ogawa H, Yasuda S.
  • Journal Title: Circulation Volume: 132 Issue: 4 Pages: 241-250
  • DOI: 10.1161/circulationaha.114.015134
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Prognostic impact of blood pressure response plus gadolinium enhancement in dilated cardiomyopathy. (2015)
  • Author(s): Tateishi E, Noguchi T, Goto Y, Morita Y, Ishibashi-Ueda H, Yamada N, Kanzaki H, Nishimura K, Miyamoto Y, Anzai T, Ogawa H, Yasuda S
  • Journal Title: Heart Volume: 101 Issue: 10 Pages: 774-780
  • DOI: 10.1136/heartjnl-2014-307007
  • Peer Reviewed / Open Access
• [Journal Article] High-intensity plaques on non-contrast T1-weighted imaging as a novel predictor of periprocedural myocardial injuries during elective percutaneous coronary intervention (2015)
  • Author(s): Asaumi Y, Noguchi T, et al.
  • Journal Title: JACC Cardiovasc Imaging Volume: 8 Issue: 6 Pages: 741-743
  • DOI: 10.1016/j.jcmg.2014.07.020
  • Peer Reviewed / Open Access
• [Presentation] 核磁気共鳴画像法を用いた冠動脈プラーク形態評価法の解明および自動測定法の開発 (2017)
  • Author(s): 細田勇人、浅海泰栄、野口暉夫
  • Organizer: 日本循環器病学会総会
  • Place of Presentation: 石川県金沢市
  • Year and Date: 2017-03-18
• [Presentation] Clinical Evidences of Cardiac Magnetic Resonance in Atherosclerotic Plaques (2016)
  • Author(s): Teruo Noguchi
  • Organizer: 第36回日本核医学会術総会
  • Place of Presentation: 愛知県名古屋市
  • Year and Date: 2016-11-03
  • Invited
• [Presentation] Can unstable plaque diagnosis with HIP (High Intensity Plaque) influence on disease prevention and treatment policy? (2016)
  • Author(s): Teruo Noguchi
  • Organizer: 日本MRI学会
  • Place of Presentation: 埼玉県大宮市
  • Year and Date: 2016-09-09
  • Invited
• [Presentation] Detection of High-Risk Atherosclerotic Coronary Plaques by Computed Tomography Angiography & Magnetic Resonance Imaging (2016)
  • Author(s): Teruo Noguchi
  • Organizer: ロシア放射線学会
  • Place of Presentation: ロシア モスクワ
  • Year and Date: 2016-05-25
  • Int'l Joint Research / Invited
• [Presentation] Non-invasive MR Technology will open up New Areas for Diagnosis and Treatment of Coronary Artery Disease (2016)
  • Author(s): Noguchi T
  • Organizer: ICMR2016
  • Place of Presentation: 韓国ソウル
  • Year and Date: 2016-03-25
  • Int'l Joint Research / Invited
• [Presentation] Attenuated anti-atherogenic effects by intensive statin treatment in diabetic patients detected by non-contrast T1-weighted magnetic resonance imaging (2016)
  • Author(s): Noguchi T
  • Organizer: 第80回日本循環器総会（JCS2016）
  • Place of Presentation: 宮城県 仙台市
  • Year and Date: 2016-03-18
  • Invited