Establishment of novel managemnt for inoperable chronic thromboembolic pulmonary hypertension patinets

• Project/Area Number: 15K09116
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular medicine
• Research Institution: Tohoku University
• Principal Investigator: Sugimura Koichiro 東北大学, 大学病院, 講師 (60375079)
• Co-Investigator(Kenkyū-buntansha): 佐藤 公雄 東北大学, 高度教養教育・学生支援機構, 准教授 (80436120)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: CTEPH / BPA / 予後 / 血行動態 / 酸素化 / 代謝 / 画像評価 / PTPA / 非手術適応慢性血栓塞栓性肺高血圧症 / 画像診断 / TAFI / OCT / 慢性血栓塞栓性肺高血圧症 / 経皮的肺動脈形成術 / MRI / 右心機能 / バイオマーカー

Outline of Final Research Achievements

We have achieved some certain results as follows.
1)4D-MRI imaging visualizes drastic change in vortex flow after BPA. Eur Heart J. 2015 Jul 1;36(25):1630.2)Multiple beneficial effects of BPA. Circ J. 2016.3)BPA improved oxygenation with a resultant decrease in intrapulmonary shunt. Circ J. 2016 80(10):2227-34. 4)We report a significantly higher prevalence of schizophrenia in patients with CTEPH than in those with pulmonary arterial hypertension (PAH) and the general population. Int J Cardiol. 2016;207:363-4.5)BPA improves biventricular functions and in CTEPH. Circ J. 2016;80(6):1470-7.6)Dual-energy CT to estimate clinical severity of CTEPH. Eur J Radiol. 2016;85:1574-80. 7)Plasma levels of TAFI are elevated in patients with CTEPH and are correlated with resistance to clot lysis in those patients. Arterioscler Thromb Vasc Biol. 2016;36:1293-301.8)The beneficial haemodynamic effects of BPA persist for years with resultant good long-term prognosis. Eur Heart J 2017 38:3152-3159.

Research Products

• [Journal Article] Comprehensive evaluation of the effectiveness and safety of balloon pulmonary angioplasty for inoperable chronic thrombo-embolic pulmonary hypertension: Long-term effects and procedure-related complications (2017)
  • Author(s): Aoki T, Sugimura K, Tatebe S, Miura M, Yamamoto S, Yaoita N, Suzuki H, Sato H, Kozu K, Konno R, Miyata S, Nochioka K, Satoh K, Shimokawa H.
  • Journal Title: Eur Heart J. Volume: 38 Issue: 42 Pages: 3152
  • DOI: 10.1093/eurheartj/ehx530
  • Peer Reviewed / Open Access
• [Journal Article] Balloon Pulmonary Angioplasty for Chronic Thromboembolic Pulmonary Hypertension: Results of a Multicenter Registry. (2017)
  • Author(s): Ogawa A, Satoh T, Fukuda T, Sugimura K, Fukumoto Y, Emoto N, Yamada N, Yao A, Ando M, Ogino H, Tanabe N, Tsujino I, Hanaoka M, Minatoya K, Ito H, Matsubara H.
  • Journal Title: Circ Cardiovasc Qual Outcomes. Volume: 10 Issue: 11
  • DOI: 10.1161/circoutcomes.117.004029
  • Peer Reviewed / Open Access
• [Journal Article] Effects of Balloon Pulmonary Angioplasty on Oxygenation in Patients With Chronic Thromboembolic Pulmonary Hypertension – Importance of Intrapulmonary Shunt – (2016)
  • Author(s): Aoki T, Sugimura K, Nochioka K, Miura M, Tatebe S, Yamamoto S, Yaoita N, Suzuki H, Sato H, Kozu K, Miyata S, Satoh K, Shimokawa H.
  • Journal Title: Circulation Journal Volume: 80 Issue: 10 Pages: 2227-2234
  • DOI: 10.1253/circj.CJ-16-0254
  • NAID: 130005418994
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Dual-energy CT to estimate clinical severity of chronic thromboembolic pulmonary hypertension: Comparison with invasive right heart catheterization (2016)
  • Author(s): Takagi H, Ota H, Sugimura K, Otani Katharina, Tominaga J, Aoki T, Tatebe S, Miura M, Yamamoto Y, Sato H, Yaoita N, Suzuki H, Shimokawa H, Takase K
  • Journal Title: European Journal of Radiology Volume: 85 Issue: 9 Pages: 1574-1580
  • DOI: 10.1016/j.ejrad.2016.06.010
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Thrombin-activatable fibrinolysis inhibitor in chronic thromboembolic pulmonary hypertension (2016)
  • Author(s): Yaoita N, Satoh K, Satoh T, Sugimura K, Tatebe S, Yamamoto S, Aoki T, Miura M, Miyata S, Kawamura T, Horiuchi H, Fukumoto Y, Shimokawa H.
  • Journal Title: Arterioscler Thromb Vasc Biol. Volume: 36 Issue: 6 Pages: 1293
  • DOI: 10.1161/atvbaha.115.306845
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Balloon Pulmonary Angioplasty Improves Biventricular Functions and Pulmonary Flow in Chronic Thromboembolic Pulmonary Hypertension (2016)
  • Author(s): Sato H, Ota H, Sugimura K, Aoki T, Tatebe S, Miura M, Yamamoto S, Yaoita N, Suzuki H, Satoh K, Takase K, Shimokawa H.
  • Journal Title: Circulation Journal Volume: 80 Issue: 6 Pages: 1470-1477
  • DOI: 10.1253/circj.CJ-15-1187
  • NAID: 130005153583
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Multiple Beneficial Effects of Balloon Pulmonary Angioplasty in Patients With Chronic Thromboembolic Pulmonary Hypertension (2016)
  • Author(s): Tatebe S, Sugimura K, Aoki T, Miura M, Nochioka K, Miyamichi-Yamamoto S, Yaoita N, Suzuki H, Sato H, Satoh K, Fukumoto Y, Shimokawa H.
  • Journal Title: Circulation Journal Volume: 80 Issue: 4 Pages: 980-988
  • DOI: 10.1253/circj.CJ-15-1212
  • NAID: 130005139581
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Chronic thromboembolic pulmonary hypertension and schizophrenia (2016)
  • Author(s): Suzuki H, Sugimura K, Tatebe S, Aoki T, Shimokawa H
  • Journal Title: Int J Cardiol Volume: 207 Pages: 363-4
  • DOI: 10.1016/j.ijcard.2016.01.010
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Four-dimensional flow magnetic resonance imaging visualizes drastic change in vortex flow in the main pulmonary artery after percutaneous transluminal pulmonary angioplasty in a patient with chronic thromboembolic pulmonary hypertension (2015)
  • Author(s): Ota H, Sugimura K, Miura M, Shimokawa H
  • Journal Title: Eur Heart J Volume: 36 Issue: 25 Pages: 1630-1630
  • DOI: 10.1093/eurheartj/ehv054
  • Peer Reviewed / Int'l Joint Research
• [Presentation] CTEPH における内服治療 (2017)
  • Author(s): 杉村宏一郎
  • Organizer: 第2回日本肺高血圧・肺循環学会学術集会
  • Invited
• [Presentation] LBCS6-6:Advanced vascular interventions: techniques and outcomeslong-term beneficial effects of balloon pulmonary angioplasty on hemodynamics and prognosis in patients with inoperable chronic thromboembolic pulmonary hypertension. (2017)
  • Author(s): 23.Aoki T, Sugimura K, Tatebe S, Yamamoto S, Yaoita N, Kozu K, Sato H, Konno R, Nochioka K, Satoh K, Shimokawa H.
  • Organizer: 第81回日本循環器学会学術集会
• [Presentation] 慢性血栓塞栓性肺高血圧症に対するバルーン肺動脈形成術の包括的評価―長期予後と合併症 (2017)
  • Author(s): 84.青木竜男、杉村宏一郎、建部俊介、山本沙織、矢尾板信裕、佐藤 遥、神津克也、紺野 亮、後岡広太郎、佐藤公雄、下川宏明
  • Organizer: 第58回日本脈管学会学術集会
• [Presentation] バルーン肺動脈形成術後の慢性血栓塞栓性肺高血圧症における運動負荷右心カテーテル (2017)
  • Author(s): 85.青木竜男、杉村宏一郎、建部俊介、山本沙織、矢尾板信裕、佐藤 遥、神津克也、紺野 亮、後岡広太郎、佐藤公雄、下川宏明
  • Organizer: 第58回日本脈管学会学術集会
• [Presentation] Sex differences in the prevalence and effectiveness of balloon pulmonary angioplasty in chronic thromboembolic pulmonary hypertension in Japan. (2017)
  • Author(s): 91.Aoki T, Sugimura K, Yamamoto S, Shimizu T, Yaoita N, Sato H, Kozu K, Konno R, Nochioka K, Satoh K, Shimokawa H.
  • Organizer: The 8th Congress of the International Society for Gender Medicine
  • Int'l Joint Research
• [Presentation] Balloon pulmonary angioplasty ameliorates long-term survival of patients with inoperable chronic thromboembolic pulmonary hypertension (2017)
  • Author(s): Tatebe S, Sugimura K, Aoki T, Yamamoto S, Yaoita N, Sato H, Konno R, Satoh K, Shimokawa H.
  • Organizer: The 8th Congress of the International Society for Gender Medicine
  • Int'l Joint Research
• [Presentation] Balloon pulmonary angioplasty ameliorates long-term survival of patients with inoperable chronic thromboembolic pulmonary hypertension (2017)
  • Author(s): 93.Tatebe S, Sugimura K, Aoki T, Yamamoto S, Yaoita N, Sato H, Konno R, Satoh K, Shimokawa H
  • Organizer: ESC Congress 2017
  • Int'l Joint Research
• [Presentation] Comprehensive evaluation of the effectiveness and safety of balloon pulmonary angioplasty for inoperable chronic thromboembolic pulmonary hypertension - long-term effects and complications. (2017)
  • Author(s): 94.Aoki T, Sugimura K, Tatebe S, Miura M, Yamamoto S, Yaoita N, Suzuki H, Sato H, Kozu K, Konno R, Nochioka K, Satoh K, Shimokawa H
  • Organizer: ESC Congress 2017
  • Int'l Joint Research
• [Presentation] バルーン肺動脈形成術後のCTEPH における運動負荷右心カテーテル (2017)
  • Author(s): 95.青木竜男、杉村宏一郎、建部俊介、山本沙織、矢尾板信裕、佐藤 遥、神津克也、紺野 亮、後岡広太朗、佐藤公雄、下川宏明
  • Organizer: 第2回日本肺高血圧・肺循環学会学術集会
• [Presentation] Inoperable CTEPH に対する BPA 治療の長期予後 (2017)
  • Author(s): 96.建部俊介、杉村宏一郎、青木竜男、山本沙織、矢尾板信裕、佐藤 遥、神津克也、紺野 亮、佐藤公雄、下川宏明
  • Organizer: 第2回日本肺高血圧・肺循環学会学術集会
• [Presentation] 慢性血栓塞栓性肺高血圧症に対する血管拡張薬中止の影響 (2017)
  • Author(s): 100.矢尾板信裕、杉村宏一郎、青木竜男、建部俊介、山本沙織、佐藤公雄、下川宏明
  • Organizer: 第2回日本肺高血圧・肺循環学会学術集会
• [Presentation] CTEPH とPAH の鑑別における呼気ガス分析の有用性 (2017)
  • Author(s): 101.秋月三奈、杉村宏一郎、青木竜男、柿花隆昭、上月正博、下川宏明
  • Organizer: 第2回日本肺高血圧・肺循環学会学術集会
• [Presentation] 慢性血栓塞栓性肺高血圧症に対するBPAの合併症と予後の検討 (2016)
  • Author(s): 69.青木竜男、杉村宏一郎、建部俊介、三浦正暢、山本沙織、矢尾板信裕、佐藤遥、神津克也、佐藤公雄、下川宏明
  • Organizer: 第57回 日本脈管学会総会
  • Place of Presentation: 奈良、ホテル日航奈良
  • Year and Date: 2016-10-13
• [Presentation] 肺動脈形成術のすべてOCT guided BPA (2016)
  • Author(s): 杉村宏一郎 青木竜男 建部俊介 山本沙織 矢尾板信裕 鈴木秀明 佐藤遥 神津克也 佐藤公雄 下川宏明
  • Organizer: 第1回日本肺高血圧症・肺循環学会学術集会
  • Place of Presentation: 東京、京王プラザホテル
  • Year and Date: 2016-10-01
  • Invited
• [Presentation] CTEPH に対する呼気ガス分析を用いた非侵襲的な重症度評価法 (2016)
  • Author(s): 80.秋月 三奈、杉村 宏一郎、青木 竜男、柿花 隆昭、伊藤 修、上月 正博、下川 宏明
  • Organizer: 第1回日本肺高血圧・肺循環学会学術集会
  • Place of Presentation: 東京、京王プラザホテル
  • Year and Date: 2016-10-01
• [Presentation] 慢性血栓塞栓性肺高血圧に対する呼気ガス分析を用いた非侵襲的な重症度評価法 (2016)
  • Author(s): 16.秋月三奈、杉村宏一郎、青木竜男、柿花隆昭、森信芳、伊藤修、下川宏明、上月正博
  • Organizer: 第22回日本心臓リハビリテーション学会学術集会
  • Place of Presentation: 東京、東京国際フォーラム
  • Year and Date: 2016-07-16
• [Presentation] 慢性血栓塞栓性肺高血圧症における経皮的肺動脈形成術 (2016)
  • Author(s): 杉村宏一郎
  • Organizer: 第80回日本循環器病学会総会
  • Place of Presentation: 仙台国際センター（仙台市）
  • Year and Date: 2016-03-18
  • Int'l Joint Research / Invited
• [Presentation] Efficacy and Safety ofBalloon Pulmonary Angioplastyin Patients withInoperable Chronic Thromboembolic Pulmonary Hypertension (2016)
  • Author(s): Koichiro Sugimura
  • Organizer: 第80回日本循環器病学会総会
  • Place of Presentation: 仙台国際センター（仙台市）
  • Year and Date: 2016-03-18
  • Int'l Joint Research / Invited
• [Presentation] 慢性血栓塞栓性肺高血圧症 (2016)
  • Author(s): 杉村宏一郎
  • Organizer: 第80回日本循環器病学会総会
  • Place of Presentation: 仙台国際センター（仙台市）
  • Year and Date: 2016-03-18
  • Int'l Joint Research / Invited
• [Presentation] Novel Strategy for Catheter Interventional Treatment for Chronic Thromboembolic Pulmonary Hypertension (2015)
  • Author(s): Koichiro Sugimura
  • Organizer: European Society of Cardiology Congress 2015
  • Place of Presentation: London UK
  • Year and Date: 2015-08-29
  • Int'l Joint Research
• [Presentation] Novel Strategy for Catheter Interventional Treatment for Chronic Thromboembolic Pulmonary Hypertension Guided by Optical Coherence Tomography Imaging (2015)
  • Author(s): Koichiro Sugimura
  • Organizer: American Thoracic Society 2015 International Conference
  • Place of Presentation: Denver USA
  • Year and Date: 2015-05-15
  • Int'l Joint Research
• [Book] 肺高血圧症の治療はどう変貌したか (2015)
  • Author(s): 杉村宏一郎 下川宏明
  • Total Pages: 7
  • Publisher: メジカルビュー
• [Remarks] 東北大学病院循環器内科
  • URL: http://www.cardio.med.tohoku.ac.jp/
• [Remarks] 東北大学病院循環器内科
  • URL: http://www.cardio.med.tohoku.ac.jp/class/achievements/index.html