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Ex Vivo Expanded Erythroblast-Transplantation versus autologous bone marrow mononuclear cell implantation for patient with critical limb ischemia

Research Project

Project/Area Number 15K09117
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Cardiovascular medicine
Research InstitutionNiigata University

Principal Investigator

Ozawa Takuya  新潟大学, 医歯学系, 講師 (70467075)

Co-Investigator(Kenkyū-buntansha) 柳川 貴央  新潟大学, 医歯学総合病院, 特任助教 (10625586)
森山 雅人  新潟大学, 医歯学系, 准教授 (30598131)
増子 正義  新潟大学, 医歯学総合病院, 准教授 (70397115)
須田 将吉  新潟大学, 医歯学総合病院, 医員 (70714509)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords臨床心血管病態学 / 血管再生 / 赤芽球 / 細胞療法 / 体外増幅
Outline of Final Research Achievements

We investigated the safety and efficacy of angiogenic cell therapy by implantation of ex vivo expanded immature erythroblasts cultured from autologous bone marrow cells(EVEETA) for patient with critical limb ischemia comparing to implantation of bone marrow mononuclear cells(BMI). Freedom from major/minor amputation rate was significantly higher in EVEETA than BMI.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (6 results)

All 2018 2017 2016 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 2 results) Presentation (3 results) (of which Int'l Joint Research: 2 results) Remarks (1 results)

  • [Journal Article] Low-Dose Erythropoietin in Patients With ST-Segment Elevation Myocardial Infarction (EPO-AMI-II) ― A Randomized Controlled Clinical Trial ―2018

    • Author(s)
      Minamino, Tetsuo; Higo, Shuichiro; Araki, Ryo; Hikoso, Shungo; Nakatani, Daisaku; Suzuki, Hiroshi; Yamada, Takahisa; Okutsu, Masaaki; Yamamoto, Kouji; Fujio, Yasushi; Ishida, Yoshio; Ozawa, Takuya; Kato, Kiminori; Toba, Ken; Aizawa, Yoshifusa; Komuro, Issei
    • Journal Title

      Circulation Journal

      Volume: 82 Issue: 4 Pages: 1083-1091

    • DOI

      10.1253/circj.CJ-17-0889

    • NAID

      130006528526

    • ISSN
      1346-9843, 1347-4820
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Dual Antiplatelet Therapy Guided by <i>CYP2C19</i> Polymorphisms after Implantation of Second-Generation Drug-Eluting Stents for Management of Acute Coronary Syndrome2018

    • Author(s)
      Ozawa T, Yanagawa T, Minamino T, et al
    • Journal Title

      International Heart Journal

      Volume: 59 Issue: 1 Pages: 21-26

    • DOI

      10.1536/ihj.17-005

    • NAID

      130006321382

    • ISSN
      1349-2365, 1349-3299
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Effect of Osteoporosis Therapy with a Receptor Activator for NFκ-B Ligand Inhibitor on Coronary Calcifications.2017

    • Author(s)
      池上龍太郎、小澤拓也、須田将吉、柳川貴央、尾崎和幸、樋口浩太郎、中村裕一、松原琢、広野暁、南野徹
    • Organizer
      第81回日本循環器学会学術集会
    • Place of Presentation
      石川県立音楽堂 他(石川県金沢市)
    • Year and Date
      2017-03-17
    • Related Report
      2016 Research-status Report
  • [Presentation] A crucial role for senescence-associated glycoprotein in the maintenance of vessel homeostasis2016

    • Author(s)
      Masayoshi Suda, Ippei Shimizu, Yohko Yoshida, Yuka Hayashi, Goro Katsuumi, Hiromi Kayamori, Ryutaro Ikegami, Takayuki Wakasugi, Takuya Ozawa, Tohru Minamino
    • Organizer
      19th International Vascular Biology Meeting
    • Place of Presentation
      アメリカ・ボストン
    • Year and Date
      2016-10-29
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] A crucial role for senescence-associated glycoprotein in the maintenance of vessel homeostasis2016

    • Author(s)
      Masayoshi Suda, Ippei Shimizu, Yohko Yoshida, Yuka Hayashi, Goro Katsuumi, Hiromi Kayamori, Ryutaro Ikegami, Takayuki Wakasugi, Takuya Ozawa, Tohru Minamino
    • Organizer
      欧州心臓病学会(ESC)2016
    • Place of Presentation
      イタリア・ローマ
    • Year and Date
      2016-08-26
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Remarks] 新潟大学医歯学総合病院 生命科学医療センター 末梢動脈における再生医療

    • URL

      http://bmrctr.jp/saisei/public/public3

    • Related Report
      2017 Annual Research Report 2015 Research-status Report

URL: 

Published: 2015-04-16   Modified: 2019-03-29  

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