Discovery and mechanistic analysis of a novel molecule associated with high-density lipoprotein metabolism using whole exome sequencing

• Project/Area Number: 15K09118
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular medicine
• Research Institution: Kanazawa University
• Principal Investigator: Kawashiri Masaaki 金沢大学, 医学系, 准教授 (90345637)
• Co-Investigator(Kenkyū-buntansha): 野原 淳 金沢大学, 保健管理センター, 助教 (50313648) ; 多田 隼人 金沢大学, 附属病院, 助教 (90623653)
• Project Period (FY): 2015-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 高比重リポ蛋白 / 動脈硬化 / 全エクソームシーケンス

Outline of Final Research Achievements

The causal genes of 2 cases with extreme hypo-HDL-cholesterolemia (2mg/dL, 6mg/dL) and single case with extreme hyper-HDL-cholesterolemia (170mg/dL) were analyzed by whole exome sequencing. The causes of both of hypo-HDL-cholesterolemia were compound heterozygosity of ABCA1 gene (c.6230C>A/c.6137G>A and c.2842G>A/c.1130C>T). The potential causal gene of the extreme hyper-HDL-cholesterolemia supposed to be "molecule X". The gene was introduced into HEK293 cells. The cholesterol efflux capacity of "molecule X" was not different from that of controls, which suggested the hyper-HDL-cholesterolemia of this index case was not due to increased cholesterol efflux capacity.

Academic Significance and Societal Importance of the Research Achievements

HDLコレステロールは俗に善玉コレステロールと呼ばれ、動脈硬化抑制的と考えられている。著明な低HDLコレステロール血症と高HDLコレステロール血症の原因遺伝子を、全エクソームシーケンス法という新しい手法を用いて検討した。前者は既報のABCA1遺伝子異常であることが比較的短期間で判明し、特に潜性遺伝性疾患の遺伝子解析に有益な手法と考えられる。高HDLコレステロール血症の原因遺伝子は新規の分子であることが想定された。そのメカニズムは、コレステロール引き抜き能亢進によらない可能性が示唆された。

Research Products

• [Journal Article] Genetic Variations, Triglycerides, and Atherosclerotic Disease (2019)
  • Author(s): Tada H, Kawashiri MA.
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 26 Issue: 2 Pages: 128-131
  • DOI: 10.5551/jat.ED102
  • NAID: 130007600242
  • ISSN: 1340-3478, 1880-3873
  • Year and Date: 2019-02-01
  • Peer Reviewed / Open Access
• [Journal Article] Clinical whole exome sequencing in severe hypertriglyceridemia (2019)
  • Author(s): Tada Hayato、Nomura Akihiro、Okada Hirofumi、Nakahashi Takuya、Nozue Tsuyoshi、Hayashi Kenshi、Nohara Atsushi、Yagi Kunimasa、Inazu Akihiro、Michishita Ichiro、Mabuchi Hiroshi、Yamagishi Masakazu、Kawashiri Masa-aki
  • Journal Title: Clinica Chimica Acta Volume: 488 Pages: 31-39
  • DOI: 10.1016/j.cca.2018.10.041
  • Peer Reviewed / Open Access
• [Journal Article] Function and Immunogenicity of Gene-corrected iPSC-derived Hepatocyte-Like Cells in Restoring Low Density Lipoprotein Uptake in Homozygous Familial Hypercholesterolemia. (2019)
  • Author(s): Okada H, Nakanishi C, Yoshida S, Shimojima M, Yokawa J, Mori M, Tada H, Yoshimuta T, Hayashi K, Yamano T, Hanayama R, Yamagishi M, Kawashiri MA
  • Journal Title: Scientific reports Volume: 9 Issue: 1 Pages: 4695-4695
  • DOI: 10.1038/s41598-019-41056-w
  • Peer Reviewed
• [Journal Article] Post-prandial Remnant Lipoprotein Metabolism in Sitosterolemia (2018)
  • Author(s): Tada Hayato、Nomura Akihiro、Nohara Atsushi、Inazu Akihiro、Mabuchi Hiroshi、Yamagishi Masakazu、Kawashiri Masa-aki
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 25 Issue: 12 Pages: 1188-1195
  • DOI: 10.5551/jat.44768
  • NAID: 130007539352
  • ISSN: 1340-3478, 1880-3873
  • Year and Date: 2018-12-01
  • Peer Reviewed / Open Access
• [Journal Article] Multi-vessel Coronary Vasospasm after Beta-blocker Administration (2018)
  • Author(s): Tamura Y, Sakata K, Kawashiri MA, Yamagishi M.
  • Journal Title: Internal Medicine Volume: 57 Issue: 21 Pages: 3219-3220
  • DOI: 10.2169/internalmedicine.1165-18
  • ISSN: 0918-2918, 1349-7235
  • Year and Date: 2018-11-01
  • Peer Reviewed
• [Journal Article] Spontaneous Isolated Superior Mesenteric Artery Dissection Requiring Emergent Surgery (2018)
  • Author(s): Tanaka Y, Tada H, Takeda Y, Iino K, Hayashi K, Takemura H, Yamagishi M, Kawashiri MA.
  • Journal Title: Internal Medicine Volume: 57 Issue: 18 Pages: 2681-2684
  • DOI: 10.2169/internalmedicine.0641-17
  • NAID: 130007484205
  • ISSN: 0918-2918, 1349-7235
  • Year and Date: 2018-09-15
  • Peer Reviewed / Open Access
• [Journal Article] Sitosterolemia, Hypercholesterolemia, and Coronary Artery Disease (2018)
  • Author(s): Tada Hayato、Nohara Atsushi、Inazu Akihiro、Sakuma Nagahiko、Mabuchi Hiroshi、Kawashiri Masa-aki
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 25 Issue: 9 Pages: 783-789
  • DOI: 10.5551/jat.RV17024
  • NAID: 130007479708
  • ISSN: 1340-3478, 1880-3873
  • Year and Date: 2018-09-01
  • Peer Reviewed / Open Access
• [Journal Article] Additive Prognostic Value of Carotid Plaque Score to Enhance the Age, Creatinine, and Ejection Fraction Score in Patients with Acute Coronary Syndrome (2018)
  • Author(s): Nakahashi T, Tada H, Sakata K, Nomura A, Ohira M, Mori M, Takamura M, Hayashi K, Yamagishi M, Kawashiri MA.
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 25 Issue: 8 Pages: 709-719
  • DOI: 10.5551/jat.42317
  • NAID: 130007429842
  • ISSN: 1340-3478, 1880-3873
  • Year and Date: 2018-08-01
  • Peer Reviewed
• [Journal Article] Oral Fat Tolerance Test for Sitosterolemia and Familial Hypercholesterolemia: A Study Protocol (2018)
  • Author(s): Nomura A, Tada H, Nohara A, Kawashiri MA, Yamagishi M.
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 25 Issue: 8 Pages: 741-746
  • DOI: 10.5551/jat.42960
  • NAID: 130007429926
  • ISSN: 1340-3478, 1880-3873
  • Year and Date: 2018-08-01
  • Peer Reviewed / Open Access
• [Journal Article] Aortic Root Calcification Score as an Independent Factor for Predicting Major Adverse Cardiac Events in Familial Hypercholesterolemia (2018)
  • Author(s): Okada H, Tada H, Hayashi K, Kawashima H, Takata T, Sakata K, Nohara A, Mabuchi H, Yamagishi M, Kawashiri MA
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 25 Issue: 7 Pages: 634-642
  • DOI: 10.5551/jat.42705
  • NAID: 130007386952
  • ISSN: 1340-3478, 1880-3873
  • Year and Date: 2018-07-01
  • Peer Reviewed / Open Access
• [Journal Article] Impact of B-Type Natriuretic Peptide Level on Risk Stratification of Thromboembolism and Death in Patients With Nonvalvular Atrial Fibrillation ― The Hokuriku-Plus AF Registry ― (2018)
  • Author(s): Hayashi Kenshi、Tsuda Toyonobu、Nomura Akihiro、Fujino Noboru、Nohara Atsushi、Sakata Kenji、Konno Tetsuo、Nakanishi Chiaki、Tada Hayato、Nagata Yoji、Teramoto Ryota、Tanaka Yoshihiro、Kawashiri Masa-aki、Yamagishi Masakazu、on behalf of the Hokuriku-Plus AF Registry Investigators
  • Journal Title: Circulation Journal Volume: 82 Issue: 5 Pages: 1271-1278
  • DOI: 10.1253/circj.CJ-17-1085
  • NAID: 130006725972
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access
• [Journal Article] Impact of stent deformity induced by the kissing balloon technique for bifurcating lesions on in-stent restenosis after coronary intervention. (2018)
  • Author(s): Gamou T, Sakata K, Terai H, Horita Y, Ikeda M, Namura M, Yamagishi M, Kawashiri MA.
  • Journal Title: J Interv Cardiol. Volume: 31 Issue: 4 Pages: 421-429
  • DOI: 10.1111/joic.12504
  • Peer Reviewed
• [Journal Article] Remnant-like particles and coronary artery disease in familial hypercholesterolemia (2018)
  • Author(s): Tada H, Kawashiri MA, Nohara A, Sakata K, Inazu A, Mabuchi H, Yamagishi M, Hayashi K
  • Journal Title: Clin Chim Acta Volume: 印刷中 Pages: 120-123
  • DOI: 10.1016/j.cca.2018.04.007
  • Peer Reviewed
• [Journal Article] Amiodarone-induced reversible and irreversible hepatotoxicity: two case reports (2018)
  • Author(s): Tsuda Toyonobu、Tada Hayato、Tanaka Yoshihiro、Nishida Naoto、Yoshida Taiji、Sawada Takeshi、Sakata Kenji、Hayashi Kenshi、Kawashiri Masa-aki、Oyama Takeru、Sasaki Motoko、Kurose Nozomu、Yamagishi Masakazu
  • Journal Title: Journal of Medical Case Reports Volume: 12 Issue: 1 Pages: 95-95
  • DOI: 10.1186/s13256-018-1629-8
  • Peer Reviewed / Open Access
• [Journal Article] Paradoxical impact of decreased low-density lipoprotein cholesterol level at baseline on the long-term prognosis in patients with acute coronary syndrome. (2018)
  • Author(s): Nakahashi T, Tada H, Sakata K, Yakuta Y, Tanaka Y, Nomura A, Gamou T, Terai H, Horita Y, Ikeda M, Namura M, Takamura M, Hayashi K, Yamagishi M, Kawashiri MA.
  • Journal Title: Heart Vessels. Volume: 33 Issue: 7 Pages: 695-705
  • DOI: 10.1007/s00380-017-1111-3
  • Peer Reviewed / Open Access
• [Journal Article] Prominent Tendon Xanthomas and Abdominal Aortic Aneurysm Associated with Cerebrotendinous Xanthomatosis Identified Using Whole Exome Sequencing (2018)
  • Author(s): Tada H, Inaba S, Pozharitckaia D, Kawashiri MA.
  • Journal Title: Internal Medicine Volume: 57 Issue: 8 Pages: 1119-1122
  • DOI: 10.2169/internalmedicine.9687-17
  • NAID: 130006707877
  • ISSN: 0918-2918, 1349-7235
  • Peer Reviewed
• [Journal Article] Clinical characteristics of spontaneous isolated visceral artery dissection. (2018)
  • Author(s): Tanaka Y, Yoshimuta T, Kimura K, Iino K, Tamura Y, Sakata K, Hayashi K, Takemura H, Yamagishi M, Kawashiri MA.
  • Journal Title: J Vasc Surg. Volume: 67 Issue: 4 Pages: 1127-1133
  • DOI: 10.1016/j.jvs.2017.08.054
  • Peer Reviewed
• [Journal Article] Huge Metastatic Gastrointestinal Stromal Tumor Occupying the Right Ventricle (2018)
  • Author(s): Tamura Y, Tada H, Kato H, Iino K, Hayashi K, Kawashiri MA, Takemura H, Yamagishi M.
  • Journal Title: Circulation Journal Volume: 82 Issue: 5 Pages: 1469-1470
  • DOI: 10.1253/circj.CJ-17-0722
  • NAID: 130006726009
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access
• [Journal Article] Author Correction: Heart Failure Phenotypes Induced by Knockdown of DAPIT in Zebrafish: A New Insight into Mechanism of Dilated Cardiomyopathy (2018)
  • Author(s): Nagata Yoji、Yamagishi Masakazu、Konno Tetsuo、Nakanishi Chiaki、Asano Yoshihiro、Ito Shin、Nakajima Yuri、Seguchi Osamu、Fujino Noboru、Kawashiri Masa-aki、Takashima Seiji、Kitakaze Masafumi、Hayashi Kenshi
  • Journal Title: Scientific Reports Volume: 8 Issue: 1 Pages: 7768-7768
  • DOI: 10.1038/s41598-018-26012-4
  • Peer Reviewed / Open Access
• [Journal Article] Mendelian randomization: Its impact on cardiovascular disease. (2018)
  • Author(s): Kawashiri MA, Tada H, Nomura A, Yamagishi M.
  • Journal Title: J Cardiol. Volume: 72 Issue: 4 Pages: 307-313
  • DOI: 10.1016/j.jjcc.2018.04.007
  • Peer Reviewed / Open Access
• [Journal Article] Very late bare metal stent thrombosis in the setting of discontinuation of optimal medical therapy for 2 years. (2018)
  • Author(s): Murai K, Sakata K, Mabuchi T, Yamaguchi M, Mori M, Hayashi K, Kawashiri MA.
  • Journal Title: Cardiovasc Diagn Ther. Volume: 8 Issue: 2 Pages: 186-189
  • DOI: 10.21037/cdt.2018.03.09
  • Peer Reviewed
• [Journal Article] Effects of prehospital epinephrine administration on neurologically intact survival in bystander-witnessed out-of-hospital cardiac arrest patients with non-shockable rhythm depend on prehospital cardiopulmonary resuscitation duration required to hospital arrival. (2018)
  • Author(s): Funada A, Goto Y, Tada H, Shimojima M, Hayashi K, Kawashiri MA, Yamagishi M.
  • Journal Title: Heart Vessels. Volume: 33 Issue: 12 Pages: 1525-1533
  • DOI: 10.1007/s00380-018-1205-6
  • Peer Reviewed / Open Access
• [Journal Article] First case of sitosterolemia caused by double heterozygous mutations in ABCG5 and ABCG8 genes. (2018)
  • Author(s): Tada H, Nomura A, Yamagishi M, Kawashiri MA.
  • Journal Title: J Clin Lipidol. Volume: 12 Issue: 5 Pages: 1164-1168
  • DOI: 10.1016/j.jacl.2018.06.003
  • Peer Reviewed
• [Journal Article] Functional analysis of KCNH2 gene mutations of type 2 long QT syndrome in larval zebrafish using microscopy and electrocardiography (2018)
  • Author(s): Tanaka Yoshihiro、Hayashi Kenshi、Fujino Noboru、Konno Tetsuo、Tada Hayato、Nakanishi Chiaki、Hodatsu Akihiko、Tsuda Toyonobu、Nagata Yoji、Teramoto Ryota、Yoshida Shohei、Nomura Akihiro、Kawashiri Masa-aki、Yamagishi Masakazu
  • Journal Title: Heart and Vessels Volume: 34 Issue: 1 Pages: 159-166
  • DOI: 10.1007/s00380-018-1231-4
  • Peer Reviewed
• [Journal Article] Serum triglycerides predict first cardiovascular events in diabetic patients with hypercholesterolemia and retinopathy. (2018)
  • Author(s): Tada H, Kawashiri MA, Nomura A, Yoshimura K, Itoh H, Komuro I, Yamagishi M.
  • Journal Title: Eur J Prev Cardiol. Volume: 25 Issue: 17 Pages: 1852-1860
  • DOI: 10.1177/2047487318796989
  • Peer Reviewed
• [Journal Article] Oligogenic familial hypercholesterolemia, LDL cholesterol, and coronary artery disease (2018)
  • Author(s): Tada Hayato、Kawashiri Masa-aki、Nomura Akihiro、Teramoto Ryota、Hosomichi Kazuyoshi、Nohara Atsushi、Inazu Akihiro、Mabuchi Hiroshi、Tajima Atsushi、Yamagishi Masakazu
  • Journal Title: Journal of Clinical Lipidology Volume: 12 Issue: 6 Pages: 1436-1444
  • DOI: 10.1016/j.jacl.2018.08.006
  • Peer Reviewed
• [Journal Article] Limited effects of long-term enzyme replacement therapy on the cardiac conduction system in Fabry disease. (2018)
  • Author(s): Kaneda T, Takeda M, Suematsu T, Yamamoto R, Takata M, Higashikata T, Ino H, Tsujibata A, Hayashi K, Fujino N, Kawashiri MA.
  • Journal Title: J Cardiol Cases. Volume: 17 Issue: 5 Pages: 178-181
  • DOI: 10.1016/j.jccase.2018.01.004
  • Peer Reviewed
• [Journal Article] Severe Mitral Regurgitation As a Result of Rupture of Mitral Valve Chordae Tendineae in a Patient With Graves Disease. (2018)
  • Author(s): Karashima S, Tsuda T, Kometani M, Oka R, Demura M, Kawashiri MA, Takeda Y, Hayashi K, Yoneda T.
  • Journal Title: J Endocr Soc. Volume: 2 Issue: 11 Pages: 1246-1250
  • DOI: 10.1210/js.2018-00173
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Associations between questionnaires on lifestyle and atherosclerotic cardiovascular disease in a Japanese general population: A cross-sectional study. (2018)
  • Author(s): Tada H, Kawashiri MA, Yasuda K, Yamagishi M.
  • Journal Title: PLoS One. Volume: 13 Issue: 11 Pages: e0208135-e0208135
  • DOI: 10.1371/journal.pone.0208135
  • Peer Reviewed
• [Journal Article] Impact of genetic testing on low-density lipoprotein cholesterol in patients with familial hypercholesterolemia (GenTLe-FH): a randomised waiting list controlled open-label study protocol. (2018)
  • Author(s): Nomura A, Tada H, Okada H, Nohara A, Ishikawa H, Yoshimura K, Kawashiri MA.
  • Journal Title: BMJ Open. Volume: 8 Issue: 12 Pages: e023636-e023636
  • DOI: 10.1136/bmjopen-2018-023636
  • Peer Reviewed
• [Journal Article] Traumatic Esophageal Injury Detected by Transthoracic Echocardiography (2018)
  • Author(s): Oe K, Araki T, Hayashi K, Kawashiri MA.
  • Journal Title: Internal Medicine Volume: 57 Issue: 3 Pages: 441-442
  • DOI: 10.2169/internalmedicine.9494-17
  • NAID: 130006329630
  • ISSN: 0918-2918, 1349-7235
  • Peer Reviewed
• [Journal Article] Molecular and functional characterization of familial chylomicronemia syndrome. (2018)
  • Author(s): Teramoto R, Tada H, Kawashiri MA, Nohara A, Nakahashi T, Konno T, Inazu A, Mabuchi H, Yamagishi M, Hayashi K.
  • Journal Title: Atherosclerosis. Volume: 269 Pages: 272-278
  • DOI: 10.1016/j.atherosclerosis.2017.11.006
  • Peer Reviewed
• [Journal Article] Characteristics of induced pluripotent stem cells from clinically divergent female monozygotic twins with Danon disease. (2018)
  • Author(s): Yoshida S, Nakanishi C, Okada H, Mori M, Yokawa J, Yoshimuta T, Ohta K, Konno T, Fujino N, Kawashiri MA, Yachie A, Yamagishi M, Hayashi K.
  • Journal Title: J Mol Cell Cardiol. Volume: 114 Pages: 234-242
  • DOI: 10.1016/j.yjmcc.2017.11.019
  • Peer Reviewed / Open Access
• [Journal Article] Assessment of arterial stiffness in patients with familial hypercholesterolemia. (2018)
  • Author(s): Tada H, Kawashiri MA, Nohara A, Inazu A, Mabuchi H, Yamagishi M.
  • Journal Title: J Clin Lipidol. Volume: 12 Issue: 2 Pages: 397-402
  • DOI: 10.1016/j.jacl.2017.12.002
  • Peer Reviewed
• [Journal Article] Duration of cardiopulmonary resuscitation in patients without prehospital return of spontaneous circulation after out-of-hospital cardiac arrest: Results from a severity stratification analysis. (2018)
  • Author(s): Funada A, Goto Y, Tada H, Teramoto R, Shimojima M, Hayashi K, Kawashiri MA, Yamagishi M.
  • Journal Title: Resuscitation. Volume: 124 Pages: 69-75
  • DOI: 10.1016/j.resuscitation.2018.01.008
  • Peer Reviewed
• [Journal Article] Unsolved Antiatherogenic Mechanism of n-3 Polyunsaturated Fatty Acids (2018)
  • Author(s): Kawashiri MA, Tada H, Yamagishi M.
  • Journal Title: Circulation Journal Volume: 82 Issue: 2 Pages: 332-333
  • DOI: 10.1253/circj.CJ-17-1252
  • NAID: 130006321847
  • ISSN: 1346-9843, 1347-4820
• [Journal Article] Late Gadolinium Enhancement for Prediction of Mutation-Positive Hypertrophic Cardiomyopathy on the Basis of Panel-Wide Sequencing (2018)
  • Author(s): Teramoto R, Fujino N, Konno T, Nomura A, Nagata Y, Tsuda T, Tada H, Sakata K, Yamagishi M, Hayashi K, Kawashiri MA.
  • Journal Title: Circulation Journal Volume: 82 Issue: 4 Pages: 1139-1148
  • DOI: 10.1253/circj.CJ-17-1012
  • NAID: 130006528636
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access
• [Journal Article] Development and external validation of a post-discharge bleeding risk score in patients with acute coronary syndrome: The BleeMACS score. (2018)
  • Author(s): Raposeiras-Roubin S, Kawashiri MA, Nakahayshi T, Sakata K, Yamagishi M, Abu-Assi E, et al.
  • Journal Title: Int J Cardiol. Volume: 254 Pages: 10-15
  • DOI: 10.1016/j.ijcard.2017.10.103
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] How to implement clinical guidelines to optimise familial hypercholesterolaemia diagnosis and treatment. (2017)
  • Author(s): Farnier M, Civeira F, Descamps O, Kawashiri MA, Grigore L, Vohnout B
  • Journal Title: Atheroscler Suppl. Volume: 26 Pages: 25-35
  • DOI: 10.1016/s1567-5688(17)30022-3
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Protein-Truncating Variants at the Cholesteryl Ester Transfer Protein Gene and Risk for Coronary Heart Disease. (2017)
  • Author(s): Nomura A, Tada H, Kawashiri MA, Inazu A, Yamagishi M, Rader DJ, Kathiresan S, et al.
  • Journal Title: Circ Res. Volume: 121 Issue: 1 Pages: 81-88
  • DOI: 10.1161/circresaha.117.311145
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Effect of Reverse Vessel Remodeling on Regression of Coronary Atherosclerosis in Patients Treated With Aggressive Lipid- and Blood Pressure-Lowering Therapy ― Insight From MILLION Study ― (2017)
  • Author(s): Gamou T, Sakata K, Tada H, Konno T, Hayashi K, Ino H, Yamagishi M, Kawashiri MA; MILLION Study Group.
  • Journal Title: Circulation Journal Volume: 81 Issue: 10 Pages: 1490-1495
  • DOI: 10.1253/circj.CJ-16-1253
  • NAID: 120006338349
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed
• [Journal Article] Early endothelialization associated with a biolimus A9 bioresorbable polymer stent in a porcine coronary model. (2017)
  • Author(s): Mori M, Sakata K, Nakanishi C, Nakahashi T, Kawashiri MA, Yoshioka K, Takuwa Y, Okada H, Yokawa JI, Shimojima M, Yoshimuta T, Yoshida S, Yamagishi M, Hayashi K.
  • Journal Title: Heart Vessels. Volume: 32 Issue: 10 Pages: 1244-1252
  • DOI: 10.1007/s00380-017-0992-5
  • Peer Reviewed
• [Journal Article] Do We Expect Any Pleiotropic Effect of Proprotein Convertase Subtilisin/Kexin Type 9 Inhibition for Reducing Cardiovascular Events Beyond Low-Density Lipoprotein Cholesterol Reduction? (2017)
  • Author(s): Tada H, Kawashiri MA, Yamagishi M.
  • Journal Title: Circulation Journal Volume: 81 Issue: 8 Pages: 1098-1099
  • DOI: 10.1253/circj.CJ-17-0586
  • NAID: 130005859014
  • ISSN: 1346-9843, 1347-4820
• [Journal Article] Prognostic superiority of coronary artery bypass grafting to percutaneous coronary intervention in non-diabetic patients with anatomically complex multivessel coronary artery disease. (2017)
  • Author(s): Sakata K, Nakahashi T, Kawashiri MA.
  • Journal Title: Cardiovasc Diagn Ther. Volume: 7 Issue: S2 Pages: S77-S81
  • DOI: 10.21037/cdt.2017.01.14
• [Journal Article] Impact of Aging on High-sensitivity Cardiac Troponin T in Patients Suspected of Acute Myocardial Infarction (2017)
  • Author(s): Ichise T, Tada H, Sakata K, Kawashiri MA, Yamagishi M, Hayashi K.
  • Journal Title: Internal Medicine Volume: 56 Issue: 16 Pages: 2097-2102
  • DOI: 10.2169/internalmedicine.8510-16
  • NAID: 130005973761
  • ISSN: 0918-2918, 1349-7235
  • Peer Reviewed
• [Journal Article] Application of an enhanced device to transluminal retrieval of malappositioned coronary stents: An experimental study. (2017)
  • Author(s): Mori M, Sakata K, Yokawa J, Nakanishi C, Okada H, Shimojima M, Yoshida S, Yoshimuta T, Hayashi K, Yamagishi M, Kawashiri MA.
  • Journal Title: J Interv Cardiol. Volume: 30 Issue: 6 Pages: 537-543
  • DOI: 10.1111/joic.12429
  • Peer Reviewed
• [Journal Article] Impact of evolocumab treatment on low-density lipoprotein cholesterol levels in heterozygous familial hypercholesterolemic patients withdrawing from regular apheresis. (2017)
  • Author(s): Kawashiri MA, Nohara A, Higashikata T, Tada H, Nakanishi C, Okada H, Konno T, Sakata K, Hayashi K, Inazu A, Mabuchi H, Yamagishi M.
  • Journal Title: Atherosclerosis. Volume: 265 Pages: 225-230
  • DOI: 10.1016/j.atherosclerosis.2017.09.011
  • Peer Reviewed
• [Journal Article] Assessments of Carotid Artery Plaque Burden in Patients With Familial Hypercholesterolemia. (2017)
  • Author(s): Tada H, Kawashiri MA, Okada H, Nakahashi T, Sakata K, Nohara A, Inazu A, Mabuchi H, Yamagishi M, Hayashi K.
  • Journal Title: Am J Cardiol. Volume: 120 Issue: 11 Pages: 1955-1960
  • DOI: 10.1016/j.amjcard.2017.08.012
  • Peer Reviewed
• [Journal Article] Huge right ventricular mass lesion associated with genital malignant tumor: a case report. (2017)
  • Author(s): Higashi M, Hodatsu A, Uchiyama K, Tada H, Mori M, Ohira M, Hayashi K, Kawashiri MA.
  • Journal Title: J Med Case Rep. Volume: 11 Issue: 1 Pages: 282-282
  • DOI: 10.1186/s13256-017-1439-4
  • Peer Reviewed
• [Journal Article] Heat Failure Phenotypes Induced by Knockdown of DAPIT in Zebrafish: A New Insight into Mechanism of Dilated Cardiomyopathy. (2017)
  • Author(s): Nagata Y, Yamagishi M, Konno T, Nakanishi C, Asano Y, Ito S, Nakajima Y, Seguchi O, Fujino N, Kawashiri MA, Takashima S, Kitakaze M, Hayashi K.
  • Journal Title: Sci Rep. Volume: 7 Issue: 1 Pages: 17417-17417
  • DOI: 10.1038/s41598-017-17572-y
  • Peer Reviewed / Open Access
• [Journal Article] Impact of triple antithrombotic therapy in patients with acute coronary syndrome undergoing percutaneous coronary intervention in real-world practice. (2017)
  • Author(s): Yan Y, Kawashiri MA, Kedev S, et al.
  • Journal Title: J Geriatr Cardiol. Volume: 14 Pages: 679-687
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Ventricular Fibrillation Associated With Dynamic Changes in J-Point Elevation in a Patient With Silent Thyroiditis. (2017)
  • Author(s): Karashima S, Tsuda T, Wakabayashi Y, Kometani M, Demura M, Ichise T, Kawashiri MA, Takeda Y, Hayashi K, Yoneda T.
  • Journal Title: J Endocr Soc. Volume: 2 Issue: 2 Pages: 135-139
  • DOI: 10.1210/js.2017-00276
  • Peer Reviewed
• [Journal Article] Lipid Management in a Japanese Community:Attainment Rate of Target Set by the Japan Atherosclerosis Society Guidelines for the Prevention of Atherosclerotic Cardiovascular Diseases 2012 (2017)
  • Author(s): Tada H, Kawashiri MA, Nohara A, Inazu A, Kobayashi J, Yasuda K, Mabuchi H, Yamagishi M, Hayashi K.
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 24 Issue: 3 Pages: 338-345
  • DOI: 10.5551/jat.36004
  • NAID: 130005397947
  • ISSN: 1340-3478, 1880-3873
  • Peer Reviewed / Open Access
• [Journal Article] Optimal Medical Therapy in Patients with Malignancy Undergoing Percutaneous Coronary Intervention for Acute Coronary Syndrome: a BleeMACS Sub-Study. (2017)
  • Author(s): Iannaccone M, D Ascenzo F, De Filippo O, Gagliardi M, Southern DA et al.
  • Journal Title: Am J Cardiovasc Drugs. Volume: 17 Issue: 1 Pages: 61-71
  • DOI: 10.1007/s40256-016-0196-x
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Impact of combined lipid lowering and blood pressure control on coronary plaque: myocardial ischemia treated by percutaneous coronary intervention and plaque regression by lipid lowering and blood pressure controlling assessed by intravascular ultrasonography (MILLION) study. (2017)
  • Author(s): Kawashiri MA, Sakata K, Hayashi K, Gamou T, Kanaya H, Miwa K, Ueda K, Higashikata T, Mizuno S, Michishita I, Namura M, Nitta Y, Katsuda S, Okeie K, Hirase H, Tada H, Uchiyama K, Konno T, Ino H, Nagase K, Yamagishi M; Behalf of the MILLION Study Group..
  • Journal Title: Heart Vessels. Volume: -
  • Peer Reviewed / Open Access
• [Journal Article] Comprehensive genotyping in dyslipidemia: mendelian dyslipidemias caused by rare variants and Mendelian randomization studies using common variants. (2017)
  • Author(s): Tada H, Kawashiri MA, Yamagishi M.
  • Journal Title: J Hum Genet. Volume: 62 Issue: 4 Pages: 453-458
  • DOI: 10.1038/jhg.2016.159
  • NAID: 40021158213
  • Peer Reviewed / Open Access
• [Journal Article] Impact of clinical signs and genetic diagnosis of familial hypercholesterolaemia on the prevalence of coronary artery disease in patients with severe hypercholesterolaemia. (2017)
  • Author(s): Tada H, Kawashiri MA, Nohara A, Inazu A, Mabuchi H, Yamagishi M.
  • Journal Title: Eur Heart J. Volume: - Issue: 20 Pages: 1573-1579
  • DOI: 10.1093/eurheartj/ehx004
  • Peer Reviewed / Open Access
• [Journal Article] Complete or incomplete coronary revascularization in patients with myocardial infarction and multivessel disease. A propensity score analysis from the "real life" BleeMACS (Bleeding complications in a Multicenter registry of patients discharged with diagnosis of Acute Coronary Syndrome) registry. (2017)
  • Author(s): Quadri G, D Ascenzo F, Moretti C, D'Amico M, Raposeiras-RoubS et al.
  • Journal Title: EuroIntervention. Volume: - Issue: 4 Pages: 407-414
  • DOI: 10.4244/eij-d-16-00350
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Renal glucosuria is not associated with atherosclerotic cardiovascular disease outcome in a general Japanese community. (2017)
  • Author(s): Tada H, Kawashiri MA, Sakata K, Yoneda T, Yasuda K, Yamagishi M, Hayashi K.
  • Journal Title: Atherosclerosis. Volume: - Pages: 111-116
  • DOI: 10.1016/j.atherosclerosis.2017.02.015
  • Open Access
• [Journal Article] Clinical Perspectives of Genetic Analyses on Dyslipidemia and Coronary Artery Disease (2017)
  • Author(s): Tada H, Kawashiri MA, Yamagishi M.
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 24 Issue: 5 Pages: 452-461
  • DOI: 10.5551/jat.RV17002
  • NAID: 130005631689
  • ISSN: 1340-3478, 1880-3873
  • Peer Reviewed / Open Access
• [Journal Article] BleeMACS: rationale and design of the study. (2016)
  • Author(s): D'Ascenzo F, Abu-Assi E, Raposeiras-RoubS, Simao Henriques JP, Saucedo J et al.
  • Journal Title: J Cardiovasc Med (Hagerstown). Volume: 17 Issue: 10 Pages: 744-749
  • DOI: 10.2459/jcm.0000000000000362
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Significance of Genetic Diagnosis of Familial Hypercholesterolemia. (2016)
  • Author(s): Kawashiri MA, Tada H, Yamagishi M.
  • Journal Title: J Atheroscler Thromb. Volume: 23 Issue: 5 Pages: 554-556
  • DOI: 10.5551/jat.ed038
  • NAID: 130005149011
  • Peer Reviewed / Open Access
• [Journal Article] Changes in lipoprotein lipase and endothelial lipase mass in familial hypercholesterolemia during three-drug lipid-lowering combination therapy (2016)
  • Author(s): Tada H, Kobayashi J, Kawashiri MA, Miyashita K, Nohara A, Inazu A, Nakajima K, Mabuchi H, Yamagishi M
  • Journal Title: Lipids Health Dis Volume: 15 Issue: 1 Pages: 66-66
  • DOI: 10.1186/s12944-016-0238-z
  • NAID: 120006325352
  • Peer Reviewed / Open Access
• [Journal Article] Impact of concomitant use of proton pump inhibitors and clopidogrel or ticagrelor on clinical outcomes in patients with acute coronary syndrome. (2016)
  • Author(s): Yan Y, Wang X, Fan JY, Nie SP, Raposeiras-RoubS et al.
  • Journal Title: J Geriatr Cardiol. Volume: 13 Pages: 209-217
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A Rare Coincidence of Sitosterolemia and Familial Mediterranean Fever Identified by Whole Exome Sequencing (2016)
  • Author(s): Tada H, Kawashiri MA, Okada H, Endo S, Toyoshima Y, Konno T, Nohara A, Inazu A, Takao A, Mabuchi H, Yamagishi M, Hayashi K.
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 23 Issue: 7 Pages: 884-890
  • DOI: 10.5551/jat.34827
  • NAID: 130005160390
  • ISSN: 1340-3478, 1880-3873
  • Peer Reviewed / Open Access
• [Journal Article] Impact of Distal Protection with Filter-Type Device on Long-term Outcome after Percutaneous Coronary Intervention for Acute Myocardial Infarction: Clinical Results with Filtrap (2016)
  • Author(s): Teramoto R, Sakata K, Miwa K, Matsubara T, Yasuda T, Inoue M, Okada H, Kanaya H, Kawashiri MA, Yamagishi M, Hayashi K.
  • Journal Title: J Atheroscler Thromb. Volume: 23 Pages: 1313-1323
  • Peer Reviewed / Open Access
• [Journal Article] Safety and effectiveness of the new P2Y12r inhibitor agents vs clopidogrel in ACS patients according to the geographic area: East Asia vs Europe. (2016)
  • Author(s): Giordana F, Montefusco A, D'Ascenzo F, Moretti C, Scarano S et al.
  • Journal Title: Int J Cardiol. Volume: 220 Pages: 488-495
  • DOI: 10.1016/j.ijcard.2016.06.063
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Impact of blood transfusion on in-hospital myocardial infarctions according to patterns of acute coronary syndrome: Insights from the BleeMACS registry. (2016)
  • Author(s): Gili S, D'Ascenzo F, Lococo MF, Moretti C, Gaita F et al.
  • Journal Title: Int J Cardiol. Volume: 221 Pages: 364-370
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Impact of Baseline Angiographic Complexities Determined by Coronary Artery Bypass Grafting SYNTAX Score on the Prediction of Outcome After Percutaneous Coronary Intervention. (2016)
  • Author(s): Nakahashi T, Sakata K, Nomura A, Yakuta Y, Gamou T, Terai H, Horita Y, Ikeda M, Namura M, Takamura M, Kawashiri MA, Yamagishi M, Hayashi K.
  • Journal Title: Am J Cardiol. Volume: 118 Issue: 7 Pages: 974-979
  • DOI: 10.1016/j.amjcard.2016.07.009
  • Peer Reviewed / Open Access
• [Journal Article] Impact of concomitant use of P2Y12 inhibitors and proton pump inhibitors on ischemia events in patients with acute coronary syndrome in real world (2016)
  • Author(s): Feng ST, Yan Y, Fan JY, Wang X, Zheng W et al.
  • Journal Title: Zhonghua Yi Xue Za Zhi. Volume: 96 Pages: 2611-2615
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Myocardial Tissue Characterization of Left Ventricular Reverse Remodeling in Ischemic Cardiomyopathy. (2016)
  • Author(s): Nagata Y, Konno T, Hayashi K, Kawashiri MA.
  • Journal Title: Circ J. Volume: 80 Pages: 2427-2428
  • NAID: 130005285034
  • Peer Reviewed / Open Access
• [Journal Article] Prevalence, clinical features, and prognosis of patients with extremely low high-density lipoprotein cholesterol. (2016)
  • Author(s): Tada H, Kawashiri MA, Konno T, Nohara A, Inazu A, Mabuchi H, Yamagishi M, Hayashi K.
  • Journal Title: J Clin Lipidol. Volume: 10 Issue: 6 Pages: 1311-1317
  • DOI: 10.1016/j.jacl.2016.08.005
  • Peer Reviewed / Open Access
• [Journal Article] Common and Rare Variant Association Study for Plasma Lipids and Coronary Artery Disease (2016)
  • Author(s): Tada H, Kawashiri MA, Konno T, Yamagishi M, Hayashi K.
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 23 Issue: 3 Pages: 241-256
  • DOI: 10.5551/jat.31393
  • NAID: 130005131889
  • ISSN: 1340-3478, 1880-3873
  • Peer Reviewed / Open Access
• [Journal Article] Lipoprotein(a) in Familial Hypercholesterolemia With Proprotein Convertase Subtilisin/Kexin Type 9 (<i>PCSK9</i>) Gain-of-Function Mutations (2016)
  • Author(s): Tada H, Kawashiri MA, Yoshida T, Teramoto R, Nohara A, Konno T, Inazu A, Mabuchi H, Yamagishi M, Hayashi K.
  • Journal Title: Circulation Journal Volume: 80 Issue: 2 Pages: 512-518
  • DOI: 10.1253/circj.CJ-15-0999
  • NAID: 130005120923
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access
• [Journal Article] Usefulness of Electrocardiographic Voltage to Determine Myocardial Fibrosis in Hypertrophic Cardiomyopathy. (2016)
  • Author(s): Konno T, Nagata Y, Teramoto R, Fujino N, Nomura A, Tada H, Sakata K, Furusho H, Takamura M, Nakamura H, Kawashiri MA, Yamagishi M, Hayashi K.
  • Journal Title: Am J Cardiol. Volume: 117 Issue: 3 Pages: 443-449
  • DOI: 10.1016/j.amjcard.2015.11.015
  • Peer Reviewed / Open Access
• [Journal Article] A de novo mutation of the LDL receptor gene as the cause of familial hypercholesterolemia identified using whole exome sequencing. (2016)
  • Author(s): Tada H, Hosomichi K, Okada H, Kawashiri MA, Nohara A, Inazu A, Tomizawa S, Tajima A, Mabuchi H, Hayashi K.
  • Journal Title: Clin Chim Acta. Volume: 453 Pages: 194-196
  • DOI: 10.1016/j.cca.2015.12.028
  • Peer Reviewed / Open Access
• [Journal Article] Exome sequencing in suspected monogenic dyslipidemias. (2015)
  • Author(s): Stitziel NO, Peloso GM, Abifadel M, Cefalu AB, Fouchier S, Motazacker MM, Tada H, Larach DB, Awan Z, Haller JF, Pullinger CR, Varret M, Noto D, Tarugi P, Kawashiri MA, Nohara A, Yamagishi M, Kathiresan S. et al.
  • Journal Title: Circ Cardiovasc Genet. Volume: 8 Issue: 2 Pages: 343-50
  • DOI: 10.1161/circgenetics.114.000776
  • Peer Reviewed / Open Access
• [Journal Article] Infantile Cases of Sitosterolaemia with Novel Mutations in the ABCG5 Gene: Extreme Hypercholesterolaemia is Exacerbated by Breastfeeding. (2015)
  • Author(s): Tada H, Kawashiri MA, Takata M, Matsunami K, Imamura A, Matsuyama M, Sawada H, Nunoi H, Konno T, Hayashi K, Nohara A, Inazu A, Kobayashi J, Mabuchi H, Yamagishi M.
  • Journal Title: JIMD Rep. Volume: in press Pages: 115-122
  • DOI: 10.1007/8904_2014_404
  • ISBN: 9783662471715, 9783662471722
  • Peer Reviewed
• [Journal Article] Impact of Enhanced Production of Endogenous Heme Oxygenase-1 by Pitavastatin on Survival and Functional Activities of Bone Marrow-derived Mesenchymal Stem Cells. (2015)
  • Author(s): Kawashiri MA, Nakanishi C, Tsubokawa T, Shimojima M, Yoshida S, Yoshimuta T, Konno T, Yamagishi M, Hayashi K.
  • Journal Title: J Cardiovasc Pharmacol. Volume: in press Issue: 6 Pages: 601-606
  • DOI: 10.1097/fjc.0000000000000231
  • Peer Reviewed / Open Access
• [Journal Article] Expansion of the Clinical Application of Optical Coherence Tomography to Percutaneous Coronary Intervention and Assessment of the Instability of Coronary Atherosclerosis (2015)
  • Author(s): Sakata K, Kawashiri MA, Hayashi K.
  • Journal Title: Circulation Journal Volume: 79 Issue: 3 Pages: 513-514
  • DOI: 10.1253/circj.CJ-15-0103
  • NAID: 130004927084
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access
• [Journal Article] Extreme Contrast of Postprandial Remnant-Like Particles Formed in Abetalipoproteinemia and Homozygous Familial Hypobetalipoproteinemia. (2015)
  • Author(s): Kawashiri MA, Tada H, Hashimoto M, Taniyama M, Nakano T, Nakajima K, Inoue T, Mori M, Nakanishi C, Konno T, Hayashi K, Nohara A, Inazu A, Koizumi J, Ishihara H, Kobayashi J, Hirano T, Mabuchi H, Yamagishi M.
  • Journal Title: JIMD Rep. Volume: in press Pages: 85-94
  • DOI: 10.1007/8904_2015_415
  • ISBN: 9783662474525, 9783662474532
  • Peer Reviewed / Open Access
• [Journal Article] Whole exome sequencing combined with integrated variant annotation prediction identifies asymptomatic Tangier disease with compound heterozygous mutations in ABCA1 gene. (2015)
  • Author(s): Tada H, Kawashiri MA, Nohara A, Saito R, Tanaka Y, Nomura A, Konno T, Sakata K, Fujino N, Takamura T, Inazu A, Mabuchi H, Yamagishi M, Hayashi K.
  • Journal Title: Atherosclerosis. Volume: 240 Issue: 2 Pages: 324-9
  • DOI: 10.1016/j.atherosclerosis.2015.04.003
  • Peer Reviewed / Open Access
• [Journal Article] Whole Exome Sequencing in Monogenic Dyslipidemias (2015)
  • Author(s): Tada H, Kawashiri MA, Yamagishi M, Hayashi K.
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 22 Issue: 9 Pages: 881-885
  • DOI: 10.5551/jat.ED016
  • NAID: 130005099296
  • ISSN: 1340-3478, 1880-3873
  • Peer Reviewed / Open Access
• [Journal Article] Right ventricular hypertrophy is associated with cardiovascular events in hypertrophic cardiomyopathy: evidence from study with magnetic resonance imaging. (2015)
  • Author(s): Nagata Y, Konno T, Fujino N, Hodatsu A, Nomura A, Hayashi K, Nakamura H, Kawashiri MA, Yamagishi M.
  • Journal Title: Can J Cardiol. Volume: 31 Issue: 6 Pages: 702-708
  • DOI: 10.1016/j.cjca.2014.12.036
  • Peer Reviewed / Open Access
• [Journal Article] Impact of Elevated D-Dimer on Diagnosis of Acute Aortic Dissection With Isolated Neurological Symptoms in Ischemic Stroke (2015)
  • Author(s): Yoshimuta T, Yokoyama H, Okajima T, Tanaka H, Toyoda K, Nagatsuka K, Higashi M, Hayashi K, Kawashiri MA, Yasuda S, Yamagishi M.
  • Journal Title: Circulation Journal Volume: 79 Issue: 8 Pages: 1841-1845
  • DOI: 10.1253/circj.CJ-15-0050
  • NAID: 130005089371
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access
• [Journal Article] Atrial fibrillation: an inherited cardiovascular disease-a commentary on genetics of atrial fibrillation: from families to genomes. (2015)
  • Author(s): Tada H, Kawashiri MA, Yamagishi M, Hayashi K.
  • Journal Title: J Hum Genet. Volume: 61 Issue: 1 Pages: 3-4
  • DOI: 10.1038/jhg.2015.63
  • Peer Reviewed / Open Access
• [Journal Article] Xiphodynia Mimicking Acute Coronary Syndrome (2015)
  • Author(s): Tanaka Y, Sakata K, Waseda Y, Fujimura T, Yamada K, Oyama T, Kawashiri MA, Yamagishi M.
  • Journal Title: Internal Medicine Volume: 54 Issue: 12 Pages: 1563-1566
  • DOI: 10.2169/internalmedicine.54.3449
  • NAID: 130005075958
  • ISSN: 0918-2918, 1349-7235
  • Peer Reviewed / Open Access
• [Journal Article] Electrocardiographic QRS Fragmentation as a Marker for Myocardial Fibrosis in Hypertrophic Cardiomyopathy. (2015)
  • Author(s): Konno T, Hayashi K, Fujino N, Oka R, Nomura A, Nagata Y, Hodatsu A, Sakata K, Furusho H, Takamura M, Nakamura H, Kawashiri MA, Yamagishi M.
  • Journal Title: J Cardiovasc Electrophysiol. Volume: 26 Issue: 10 Pages: 1081-1087
  • DOI: 10.1111/jce.12742
  • Peer Reviewed / Open Access
• [Journal Article] Functional Characterization of Rare Variants Implicated in Susceptibility to Lone Atrial Fibrillation. (2015)
  • Author(s): Hayashi K, Konno T, Tada H, Tani S, Liu L, Fujino N, Nohara A, Hodatsu A, Tsuda T, Tanaka Y, Kawashiri MA, Ino H, Makita N, Yamagishi M.
  • Journal Title: Circ Arrhythm Electrophysiol. Volume: 8 Issue: 5 Pages: 1095-1104
  • DOI: 10.1161/circep.114.002519
  • Peer Reviewed / Open Access
• [Journal Article] Impact of real-time three-dimensional transesophageal echocardiography on procedural success for mitral valve repair. (2015)
  • Author(s): Mori M, Yoshimuta T, Ohira M, Yagi M, Sakata K, Konno T, Kawashiri MA, Tomita S, Watanabe G, Iino K, Takemura H, Yamagishi M, Hayashi K.
  • Journal Title: J Echocardiogr. Volume: 13 Issue: 3 Pages: 100-106
  • DOI: 10.1007/s12574-015-0255-3
  • Peer Reviewed / Open Access
• [Journal Article] Clinical characteristics of Japanese patients with severe hypertriglyceridemia (2015)
  • Author(s): Tada H, Kawashiri MA, Nakahashi T, Yagi K, Chujo D, Ohbatake A, Mori Y, Mori S, Kometani M, Fujii H, Nohara A, Inazu A, Mabuchi H, Yamagishi M, Hayashi K.
  • Journal Title: J Clin Lipidol Volume: 9 Issue: 4 Pages: 519-524
  • DOI: 10.1016/j.jacl.2015.05.004
  • Peer Reviewed / Open Access
• [Journal Article] Characterization of Autosomal Dominant Hypercholesterolemia Caused by PCSK9 Gain of Function Mutations and Its Specific Treatment With Alirocumab, a PCSK9 Monoclonal Antibody. (2015)
  • Author(s): Hopkins PN, Defesche J, Fouchier SW, Yagi K, Krempf M, Swergold GD et. al.
  • Journal Title: Circ Cardiovasc Genet Volume: 8 Issue: 6 Pages: 823-831
  • DOI: 10.1161/circgenetics.115.001129
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Determination of Early and Late Endothelial Progenitor Cells in Peripheral Circulation and Their Clinical Association with Coronary Artery Disease. (2015)
  • Author(s): Tagawa S, Nakanishi C, Mori M, Yoshimuta T, Yoshida S, Shimojima M, Yokawa J, Kawashiri MA, Yamagishi M, Hayashi K.
  • Journal Title: Int J Vasc Med. Volume: 2015 Pages: 674213-674213
  • DOI: 10.1155/2015/674213
  • NAID: 120006460376
  • Peer Reviewed / Open Access
• [Journal Article] Abrupt progression of ventricular septal perforation after primary angioplasty for acute myocardial infarction. (2015)
  • Author(s): Nakahashi T, Sakata K, Tsuda T, Tanaka Y, Ohira M, Mori M, Takata M, Kawashiri MA, Takemura H, Yamagishi M, Hayashi K.
  • Journal Title: Cardiovasc Diagn Ther. Volume: 5 Pages: 479-483
  • Peer Reviewed / Open Access
• [Presentation] Familial Hypercholesterolemia (2018)
  • Author(s): Kawashiri M
  • Organizer: 23nd Annual Scientific Meeting of the Internal Society of Cardiovascular Pharmacotherapy
  • Int'l Joint Research / Invited
• [Presentation] PCSK9を標的にした新たな冠動脈疾患治療薬の誕生：疫学研究からの新薬開発 (2018)
  • Author(s): 川尻剛照
  • Organizer: 日本慢性疾患重症化予防学会 第4回年次学術集会
  • Invited
• [Presentation] 重症家族性高コレステロール血症の治療選択におけるLp(a)の意義 (2018)
  • Author(s): 川尻剛照
  • Organizer: 第50回日本動脈硬化学会総会・学術集会
  • Invited
• [Presentation] PCSK9を標的とした新たな冠動脈疾患治療薬の誕生：疫学研究からの新薬開発 (2018)
  • Author(s): 川尻剛照
  • Organizer: 日本慢性疾患重症化予防学会 第4回年次学術集会
  • Invited
• [Presentation] Impact of evolocumab, a PCSK9 inhibitor, withdrawing from regular LDL-apheresis therapy in patients with heterozygous familial hypercholesterolemia (2017)
  • Author(s): Masaaki Kawashiri, Toshinori Higashikata, Atsushi Nohara, Chiaki Nakanishi, Hayato Tada, Hirofumi Okada, Masakazu Yamagishi
  • Organizer: 第81回日本循環器学会学術集会
  • Place of Presentation: 金沢
  • Year and Date: 2017-03-17
• [Presentation] Genetic background & pathophysiology of familial hypercholesterolemia (2017)
  • Author(s): Masaaki Kawashiri
  • Organizer: 第81回日本循環器学会学術集会
  • Place of Presentation: 金沢
  • Year and Date: 2017-03-17
  • Invited
• [Presentation] Pathophysiological conditions needed strict lipid control (2017)
  • Author(s): Masaaki Kawashiri
  • Organizer: 第81回日本循環器学会学術集会
  • Place of Presentation: 金沢
  • Year and Date: 2017-03-17
  • Invited
• [Presentation] 家族性高コレステロール血症の心血管合併症と新しい治療 (2017)
  • Author(s): 川尻剛照
  • Organizer: 日本総合健診医学会第45回大会
  • Place of Presentation: 舞浜
  • Year and Date: 2017-01-27
  • Invited
• [Presentation] 冠動脈、脳血管疾患予防におけるコレステロール低下療法の意義 (2017)
  • Author(s): 川尻剛照、多田隼人、野原淳、山岸正和
  • Organizer: 第4回日本心血管脳卒中学会学術集会
  • Invited
• [Presentation] 家族性高コレステロール血症の診断と治療 (2017)
  • Author(s): 川尻剛照
  • Organizer: 日本内科学会第71回北陸支部生涯教育講演会
  • Invited
• [Presentation] 家族性高コレステロール血症の診断 (2017)
  • Author(s): 川尻剛照、多田隼人、野原淳、馬渕宏、山岸正和
  • Organizer: 第49回日本動脈硬化学会総会・学術集会
  • Invited
• [Presentation] PCSK9阻害剤による超積極的LDLコレステロール低下療法の意義 (2017)
  • Author(s): 川尻剛照
  • Organizer: 第49回日本動脈硬化学会総会・学術集会
  • Invited
• [Presentation] Impact of evolocumab, a PCSK9 inhibitor, withdrawing from regular LDL apheresis therapy in patients with heterozygous familial hypercholesterolemia (2017)
  • Author(s): Kawashiri M, Higashikata T, Nohara A, Nakanishi C, Tada H, Okada H, Yamagishi M
  • Organizer: European Society of Cardiology 2017
  • Int'l Joint Research
• [Presentation] FHヘテロ接合体重症例の新しい治療とLDLアフェレシスの位置づけ (2016)
  • Author(s): 川尻剛照
  • Organizer: 第37回日本アフェレシス学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2016-11-25
  • Invited
• [Presentation] Who has extreme high cardiovascular in patients with familial hypercholesterolemia (2016)
  • Author(s): Masaaki Kawashiri
  • Organizer: 10th Asian-Pacific Society of Atherosclerosis & Vasular Diseases
  • Place of Presentation: 東京
  • Year and Date: 2016-07-14
  • Int'l Joint Research / Invited
• [Presentation] PCSK9の発見と臨床治療への応用 家族性高コレステロール血症の治療が変わる！ (2016)
  • Author(s): 川尻剛照
  • Organizer: 第48回日本動脈硬化学会総会・学術集会
  • Place of Presentation: 東京
  • Year and Date: 2016-07-14
  • Invited
• [Presentation] What is the major protecting mechanism of PCSK9 inhibitor against atherosclerosis? Contribution of pleiotropic effects (2016)
  • Author(s): 川尻剛照
  • Organizer: 日本心血管インターベンション学会
  • Place of Presentation: 東京
  • Year and Date: 2016-07-07
  • Invited
• [Presentation] PCSK9の発見と新たなコレステロール低下剤の開発 (2015)
  • Author(s): 川尻剛照
  • Organizer: 日本人類遺伝学会第60回大会
  • Place of Presentation: 東京
  • Year and Date: 2015-10-14
  • Invited
• [Presentation] 家族性高コレステロール血症の診断と治療の重要性 冠動脈疾患発症抑制のために (2015)
  • Author(s): 川尻剛照
  • Organizer: 第24回日本心血管インターベンション治療学会
  • Place of Presentation: 福岡
  • Year and Date: 2015-07-30
• [Presentation] A patient with compound heterozygous familial hypercholesterolemia accompanied with supravalvular aortic stenosis detected by Whole Exome Sequencing (2015)
  • Author(s): 川尻剛照、多田隼人、井上健、中西千明、森三佳、野原淳、稲津明広、馬渕宏、山岸正和
  • Organizer: 第47回日本動脈硬化学会総会・学術集会
  • Place of Presentation: 仙台
  • Year and Date: 2015-07-09
• [Presentation] 家族性高コレステロール血症を見逃さない (2015)
  • Author(s): 川尻剛照
  • Organizer: 第1回国際心血管薬物療法学会日本部会学術集会
  • Place of Presentation: 京都
  • Year and Date: 2015-06-20
  • Invited
• [Presentation] Vascular Complications in Japanese FH Patients (2015)
  • Author(s): Kawashiri M
  • Organizer: The Satellite Symposium of the ISA 2015 in Tokyo
  • Place of Presentation: Tokyo
  • Year and Date: 2015-05-21
  • Int'l Joint Research / Invited
• [Presentation] Myocardial ischemia treated with PCI and plaque regression by lipid lowering & blood pressure controlling assessed by intravascular ultrasonography (2015)
  • Author(s): Kawashiri M, Yamagishi M, MILLION study group
  • Organizer: The Society for Cardiovascular Angiography and Intervention
  • Place of Presentation: San Diego
  • Year and Date: 2015-05-06
  • Int'l Joint Research
• [Book] 虚血性心疾患 識る・診る・治す・防ぐ (2018)
  • Author(s): 川尻剛照、山岸正和
  • Total Pages: 400
  • Publisher: 中山書店
  • ISBN: 9784521745848
• [Book] 循環器疾患最新の治療2018-2019 (2018)
  • Author(s): 川尻剛照、山岸正和
  • Total Pages: 540
  • Publisher: 南江堂
  • ISBN: 9784524252183
• [Book] 医療と検査機器・試薬 (2017)
  • Author(s): 川尻剛照、多田隼人、山岸正和
  • Total Pages: 545
  • Publisher: 宇宙堂八木書店
• [Book] 動脈硬化予防 (2017)
  • Author(s): 川尻剛照
  • Total Pages: 364
  • Publisher: メジカルビュー社
• [Book] 循環器専門医 (2017)
  • Author(s): 川尻剛照、山岸正和
  • Total Pages: 318
  • Publisher: 日本循環器学会
• [Book] 診断と治療 (2017)
  • Author(s): 川尻剛照、多田隼人、山岸正和
  • Total Pages: 1607
  • Publisher: 診断と治療社
• [Book] 循環器内科 (2017)
  • Author(s): 川尻剛照、多田隼人、山岸正和
  • Total Pages: 592
  • Publisher: 科学評論社
• [Book] 総合検診 (2017)
  • Author(s): 川尻剛照
  • Total Pages: 876
  • Publisher: 日本総合健診医学会
• [Book] 心血管薬物療法 (2016)
  • Author(s): 川尻剛照、多田隼人、山岸正和
  • Total Pages: 69
  • Publisher: 国際心血管薬物療法学会日本支部
• [Book] Progress in Medicine (2016)
  • Author(s): 川尻剛照
  • Total Pages: 1713
  • Publisher: 株式会社ライフ・サイエンス
• [Book] 呼吸と循環 (2016)
  • Author(s): 川尻剛照、多田隼人、山岸正和
  • Total Pages: 1239
  • Publisher: 医学書院
• [Book] 薬局 (2016)
  • Author(s): 川尻剛照、多田隼人、山岸正和
  • Total Pages: 3540
  • Publisher: 南山堂
• [Book] 診断と治療のABC 高LDL-C血症・低HDL-C血症 (2015)
  • Author(s): 川尻剛照
  • Total Pages: 8
  • Publisher: 最新医学社
• [Book] PCSK9阻害剤 (2015)
  • Author(s): 川尻剛照
  • Total Pages: 9
  • Publisher: メディカルビュー社 血管医学
• [Book] PCSK9をターゲットとした新しい治療を識る (2015)
  • Author(s): 川尻剛照
  • Total Pages: 6
  • Publisher: メディカルビュー社 Heart View
• [Book] LDLアフェレシス (2015)
  • Author(s): 川尻剛照、多田隼人、山岸正和
  • Total Pages: 7
  • Publisher: メディカルレビュー社 The Lipid
• [Book] 頚動脈エコーで石灰化していない低輝度～等輝度プラークに効果的な薬剤は？ (2015)
  • Author(s): 川尻剛照
  • Total Pages: 2
  • Publisher: 日本医事新報社 週刊日本医事新報