| Project/Area Number |
15K09120
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cardiovascular medicine
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| Research Institution | Kobe University |
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Principal Investigator |
Otake Hiromasa 神戸大学, 医学部附属病院, 講師 (60593803)
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| Co-Investigator(Kenkyū-buntansha) |
新家 俊郎 神戸大学, 医学部附属病院, 准教授 (60379419)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | ずり応力 / 血行力学的因子 / プラークの不安定化 / Shear stress / thin cap fibroatheroma / computed tomography / OCT |
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| Outline of Final Research Achievements |
We showed that unstable, rupture prone plaque is related with several hemodynamic parameters such as wall shear stress and axial plaque stress. Also, we showed that, in patients treated with coronary stents, vessel healing is affected not only by wall shear stress, but by wall shear stress exposed time and wall shear stress variability. These findings suggest that using computational fluid dynamics analysis might help patients with coronary artery disease to prevent acute coronary event as well as stent related events such as restenosis and stent thrombosis.
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