| Project/Area Number |
15K09123
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cardiovascular medicine
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| Research Institution | Hiroshima University |
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Principal Investigator |
Umemoto Seiji 広島大学, 病院(医), 教授 (90263772)
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| Co-Investigator(Kenkyū-buntansha) |
川野 伶緒 広島大学, 病院(医), 講師 (00744210)
河村 敦子 山口大学, 大学院医学系研究科, 講師 (90509530)
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| Research Collaborator |
MITARAI Makoto
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 高血圧 / 減塩食 / 日本食 / 降圧効果 / 血圧変動性 / 家庭血圧 / blood pressure / clinical trial / diet therapy / salt restriction / I度高血圧 / 食事 / 魚油 / メタボリックシンドローム / 正常高値血圧 |
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| Outline of Final Research Achievements |
Participants with both untreated high normal BP and stage 1 hypertension were randomly assigned to consume once (J-DASH 1) or twice (J-DASH 2) daily, or their usual diet. These diets were continued for 2 months after randomization, and for the subsequent 4 months all participants consumed their usual diets. We assigned 13 each to the J-DASH 1 and J-DASH 2 groups, and 14 to the usual diet group. Clinic BP values were not different among the three groups, whereas the home morning and evening BP values were lower in the J-DASH 1 group and lowest in the J-DASH 2 group compared to the usual diet group, and these remained different among the three diet groups throughout the study period (p<0.000). In addition, home BP variability were lower in the two J-DASH groups compared to the usual diet group throughout the study period (p<0.01). The J-DASH diet 2 group showed a 3% decrease in body mass index at 2 months after randomization compared to the other two groups (p<0.01).
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