Development of high definition OCT for elucidating roles of vasa vasorum in vivo in atherosclerosis
Project/Area Number |
15K09125
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Cardiovascular medicine
|
Research Institution | Wakayama Medical University |
Principal Investigator |
Taruya Akira 和歌山県立医科大学, 医学部, 学内助教 (60612942)
|
Co-Investigator(Kenkyū-buntansha) |
西口 毅 和歌山県立医科大学, 医学部, 博士研究員 (40549771)
田中 篤 和歌山県立医科大学, 医学部, 准教授 (50458072)
|
Research Collaborator |
TEARNEY Guillermo Harvard Medical School, Pathology, Professor
LIU Jimmy Institute for Infocomm Research, Ocular Imaging Department, Professor
WONG Damon Wing Kee Institute for Infocomm Research, Ocular Imaging Department, Associate Professor
|
Project Period (FY) |
2015-04-01 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
|
Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | vasa vasorum / 光干渉断層法 / 動脈硬化 / 冠動脈疾患 / 冠動脈 / Vasa vasorum / OCT |
Outline of Final Research Achievements |
It was suggested that vasa vasorum could play an important role in vulnerability of coronary atherosclerotic plaque. However, there has been no data about the relationship between vasa vasorum in vivo and plaque characteristics due to the lack of adequate in vivo imaging modalities. In this study, we developed a high-definition catheter-type OCT that can observe human vasa vasorum in vivo, elucidated the three-dimensional structural forms of vasa vasorum in arteriosclerotic lesions of human coronary arteries, and further revealed that vasa vasorum with particular three-dimensional form are associate with vulnerability of atherosclerotic plaque.
|
Report
(4 results)
Research Products
(23 results)
-
-
-
-
[Journal Article] Local matrix metalloproteinase 9 level determines early clinical presentation of ST-segment-elevation myocardial infarction.2016
Author(s)
Tsuyoshi Nishiguchi, Atsushi Tanaka, Akira Taruya, Hiroki Emori, Yuichi Ozaki, Makoto Orii, Yasutsugu Shiono, Kunihiro Shimamura, Takeyoshi Kameyama, Takashi Yamano, Tomoyuki Yamaguchi, Yoshiki Matsuo, Yasushi Ino, Takashi Kubo, Takeshi Hozumi, Yasushi Hayashi, Takashi Akasaka
-
Journal Title
Arteriosclerosis, Thrombosis, and Vascular Biology
Volume: 37
Issue: 12
Pages: 2460-2467
DOI
Related Report
Peer Reviewed
-
[Journal Article] Current status and future perspectives of optical coherence tomography in percutaneous coronary intervention2016
Author(s)
Takashi Kubo, Yasushi Ino, Yoshiki Matsuo, Yasutsugu Shiono, Kuninobu Kashiyama, Takeyoshi Kameyama, Makoto Orii, Takashi Yamano, Tomoyuki Yamaguchi, Atsushi Tanaka, Takeshi Hozumi, Takashi Akasaka
-
Journal Title
Journal of the Japanese Coronary Association
Volume: 22
Issue: 1
Pages: 1-8
DOI
NAID
ISSN
1341-7703, 2187-1949
Related Report
Open Access
-
-
-
[Journal Article] asa Vasorum Restructuring in Human Atherosclerotic Plaque Vulnerability.2015
Author(s)
Taruya A, Tanaka A, Nishiguchi T, Matsuo Y, Ozaki Y, Kashiwagi M, Shiono Y, Orii M, Yamano T, Ino Y, Hirata K, MD, Kubo T, Akasaka T.
-
Journal Title
J Am Coll Cardiol.
Volume: 65
Issue: 23
Pages: 2469-77
DOI
Related Report
Peer Reviewed
-
-
-
[Presentation] Lesion characteristics and prognosis of heart attack without obstructive coronary artery disease2017
Author(s)
A. Taruya, A. Tanaka, T. Nishiguchi, K. Terada, H. Emori, Y. Katayama, S. Ota, Y. Ozaki, M. Kashiwagi, T. Yamano, H. Kitabata, T. Kubo, T. Hozumi, K. Shimada, T. Akasaka
Organizer
European Society of Cardiology Congress
Related Report
Int'l Joint Research
-
-
-
[Presentation] Hidden High-risk Lesions in Patients with Non-obstructive Coronary Stenosis2017
Author(s)
Akira Taruya, Atsushi Tanaka, Tsuyoshi Nishiguchi, Kosei Terada, Hiroki Emori, Yosuke Katayama, Shingo Ota, Yuichi Ozaki, Akio Kuroi, Takeyoshi Kameyama, Takashi Yamano, Yoshiki Matsuo, Yasushi Ino, Hironori Kitabata, Kazushi Takemoto, Takashi Kubo, Takeshi Hozumi, Takashi Akasaka
Organizer
日本循環器学会学術集会総会
Place of Presentation
金沢市、日本
Related Report
Int'l Joint Research
-
-
-
[Presentation] Hidden High-risk Lesions in Patients with Chest Pain Syndrome2016
Author(s)
Taruya A, Tanaka A, Nishiguchi T, Emori H, Ozaki Y, Orii M, Kameyama T, Kuroi A, Yamano T, Matsuo Y, Ino Y, Takemoto K, Kubo T, Hozumi T, Akasaka T
Organizer
European Society of Cardiology Congress
Place of Presentation
Roma, Italy
Related Report
Int'l Joint Research
-
-
[Presentation] High risk lesionを有する胸痛症候群患者の予後は不良である2016
Author(s)
樽谷 玲, 田中 篤, 江守裕紀, 片山陽介, 西口 毅, 尾﨑雄一, 柏木 学, 松尾好記, 猪野 靖, 竹本和司, 久保隆史, 穂積健之, 赤阪隆史
Organizer
日本心臓病学会学術集会
Place of Presentation
東京、日本
Related Report
Int'l Joint Research
-
-
-
-