Novel biomarker for pulmonary hypertension
| Project/Area Number |
15K09127
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cardiovascular medicine
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| Research Institution | Juntendo University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 肺高血圧症 / バイオマーカー / LR11 / 血管平滑筋細胞 / 肺高血圧 / ＬＲ１１ |
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| Outline of Final Research Achievements |
We established serum sLR11 concentration as a biomarker of pulmonary hypertension and elucidated the mechanism of pulmonary arterial hypertension development using Sugen pulmonary hypertension model rat. In pulmonary arterial hypertension (40 cases), serum sLR11 concentration was 10.9 ng / ml, which was significantly increased compared with the normal control group. Although there was no significant difference between the groups in the WHO functional classification, the 6 minute walking distance and the serum sLR11 concentration were positively correlated, suggesting that sLR11 might be an indicator of severity. In animal experiments, lung tissue LR11 protein expression increased to 1.8-fold at the early stage of disease, but was conversely reduced at the terminal stage. The above results suggest that LR11 may be a biomarker for pulmonary hypertension.
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| Academic Significance and Societal Importance of the Research Achievements |
肺高血圧症治療薬は、現在、エンドセリン受容体拮抗剤、ホスホジエステラーゼ（PDE）５阻害薬、PGI2製剤、sGC刺激薬が使用可能であるが、多剤を用いることが推奨されているが、肺動脈病変進行抑制の指標は未だない。肺動脈病変の進行を抑制しているか否かを感度良く判定するバイオマーカーの開発は、医療経済上も高価なPAH治療薬を投与する上で重要であるが、本研究では、肺高血圧治療効果判定に有用な新規バイオマーカーになる可能性が示唆された。
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Report
(5 results)
Research Products
(4 results)
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[Journal Article] Deletion of LR11 attenuates hypoxia-induced pulmonary arterial smooth muscle cell proliferation with medial thickening in mice.2016
Author(s)
Jiang L, Konishi H, Nurwidya F, Satoh K, Takahashi F, Ebinuma H, Fujimura K, Takasu K, Jiang M, Shimokawa H, Bujo H, Daida H.
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Journal Title
Arterioscler Thromb Vasc Biol.
Volume: 36
Issue: 9
Pages: 1972-1979
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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