| Project/Area Number |
15K09128
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cardiovascular medicine
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| Research Institution | Juntendo University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
SHIMADA KAZUNORI 順天堂大学, 医学部, 先任准教授 (60327814)
FUJIMOTO SHINICHIROU 順天堂大学, 医学部, 准教授 (70385871)
YOKOYAMA MIHO 順天堂大学, 医学部, 助教 (60407301)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 急性冠症候群 / 320列冠動脈CT / 冠動脈プラーク / 包括的心臓リハビリテーション / 身体活動量 / ３２０列冠動脈ＣＴ / 320列冠動脈ＣＴ |
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| Outline of Final Research Achievements |
This study is a prospective study that examined quantity and qualitative alteration of the atherosclerotic plaque using the coronary computed tomography angiography (CCTA) in patients with coronary artery disease (CAD) participating cardiac rehabilitation. We enrolled 12 CAD patients (10 men, average age 64±9 years old) who underwent CCTA between December, 2017 and August, 2016. We recommended to have aerobic exercise of 3.6 METs based on the result of cardiopulmonary exercise test, and their physical activity was 9633±3847 steps/day. After 1 year, in one case (the target vessel was left anterior descending artery) that was available for plaque analysis, the plaque volume and lipid component volume were reduced using Labeling method. Cardiac rehabilitation may retard coronary plaque progression and reduce lipid component in CAD patients. The evaluation of the quality of the plaque was possible using CCTA.
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