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Impact of comprehensive rehabilitationon coronary plaque volume and components in coronary artery disease patients

Research Project

Project/Area Number 15K09128
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Cardiovascular medicine
Research InstitutionJuntendo University

Principal Investigator

DAIDA HIROYUKI  順天堂大学, 医学部, 教授 (40197596)

Co-Investigator(Renkei-kenkyūsha) SHIMADA KAZUNORI  順天堂大学, 医学部, 先任准教授 (60327814)
FUJIMOTO SHINICHIROU  順天堂大学, 医学部, 准教授 (70385871)
YOKOYAMA MIHO  順天堂大学, 医学部, 助教 (60407301)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords急性冠症候群 / 320列冠動脈CT / 冠動脈プラーク / 包括的心臓リハビリテーション / 身体活動量 / 320列冠動脈CT / 320列冠動脈CT
Outline of Final Research Achievements

This study is a prospective study that examined quantity and qualitative alteration of the atherosclerotic plaque using the coronary computed tomography angiography (CCTA) in patients with coronary artery disease (CAD) participating cardiac rehabilitation. We enrolled 12 CAD patients (10 men, average age 64±9 years old) who underwent CCTA between December, 2017 and August, 2016. We recommended to have aerobic exercise of 3.6 METs based on the result of cardiopulmonary exercise test, and their physical activity was 9633±3847 steps/day. After 1 year, in one case (the target vessel was left anterior descending artery) that was available for plaque analysis, the plaque volume and lipid component volume were reduced using Labeling method. Cardiac rehabilitation may retard coronary plaque progression and reduce lipid component in CAD patients. The evaluation of the quality of the plaque was possible using CCTA.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (41 results)

All 2018 2017 2016 2015

All Journal Article (11 results) (of which Peer Reviewed: 10 results,  Open Access: 5 results) Presentation (29 results) (of which Int'l Joint Research: 7 results,  Invited: 2 results) Book (1 results)

  • [Journal Article] Clinical Characteristics and Long-Term Outcomes of Rotational Atherectomy - J2T Multicenter Registry2018

    • Author(s)
      Okai I, Dohi T, Okazaki S, Jujo K, Nakashima M, Otsuki H, Tanaka K, Arashi H, Okabe R, Nagura F, Nara Y, Tamura H, Kurata T, Kawashima H, Kyono H, Yamaguchi J, Miyauchi K, Kozuma K, Hagiwara N, Daida H
    • Journal Title

      Circ J.

      Volume: 82 Pages: 369-375

    • NAID

      130006321861

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Incremental Prognostic Value of Coronary Computed Tomography Angiography: High-Risk Plaque Characteristics in Asymptomatic Patients2017

    • Author(s)
      Takamura K, Fujimoto S, Kondo T, Hiki M, Kawaguchi Y, Kato E, Daida H
    • Journal Title

      J Atheroscler Thromb.

      Volume: 24 Pages: 1174-1185

    • NAID

      130006191600

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Preprocedural High-Sensitivity C-Reactive Protein Predicts Long-Term Outcome of Percutaneous Coronary Intervention.2017

    • Author(s)
      Wada H, Dohi T, Miyauchi K, Shitara J, Endo H, Doi S, Naito R, Konishi H, Tsuboi S, Ogita M, Kasai T, Hassan A, Okazaki S, Isoda K, Shimada K, Suwa S, Daida H.
    • Journal Title

      Circ J.

      Volume: 81 Pages: 90-95

    • NAID

      130005252690

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Incremental prognostic value of coronary computed tomographic angiography high-risk plaque characteristics in newly symptomatic patients.2016

    • Author(s)
      Fujimoto S, Kondo T, Takamura K, Baber U, Shinozaki T, Nishizaki Y, Kawaguchi Y, Matsumori R, Hiki M, Miyauchi K, Daida H, Hecht H, Stone GW, Narula J.
    • Journal Title

      J Cardiol.

      Volume: 67 Pages: 538-44

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Incremental predictive value for obstructive coronary artery disease by combination of Duke Clinical Score and Agatston score.2016

    • Author(s)
      Takamura K, Kondo T, Fujimoto S, Hiki M, Matsumori R, Kawaguchi Y, Amanuma M, Takase S, Daida H.
    • Journal Title

      Eur Heart J Cardiovasc Imaging.

      Volume: 17 Pages: 550-6

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Development in coronary CT angiography.2016

    • Author(s)
      Fujimoto S, Daida H.
    • Journal Title

      Juntendo Medical Journal.

      Volume: 62 Pages: 190-196

    • NAID

      130005277380

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Current status and future directions for cardiac rehabilitation in Japan.2016

    • Author(s)
      Daida H. Nishitani-Yokoyama M, Shimada K.
    • Journal Title

      Juntendo Medical Journal

      Volume: 62 Pages: 29-37

    • NAID

      130005865676

    • Related Report
      2015 Research-status Report
  • [Journal Article] Plaque Characteristics of Consecutive 31 Cases Which Cause Acute Myocardial Infarction on Coronary Computed Tomography Angiography.2015

    • Author(s)
      Fujimoto S, Kondo T, Takamura K, Kawaguchi Y, Matsumori R, Hiki M, Miyauchi K, Daida H.
    • Journal Title

      J Jpn Coron Assoc.

      Volume: 21 Pages: 287-295

    • NAID

      130005065062

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Prognostic Value of Coronary Computed Tomography (CT) Angiography and Coronary Artery Calcium Score Performed Before Revascularization.2015

    • Author(s)
      Fujimoto S, Kondo T, Kumamaru KK, Shinozaki T, Takamura K, Kawaguchi Y, Matsumori R, Hiki M, Miyauchi K, Daida H, Rybicki FJ.
    • Journal Title

      J Am Heart Assoc.

      Volume: 4

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of Phase II Comprehensive Cardiac Rehabilitation on Coronary Plaque Volume After Acute Coronary Syndrome.2015

    • Author(s)
      Nishitani-Yokoyama M, Miyauchi K, Shimada K, Miyazaki T, Ogita M, Okazaki S, Shioya M, Koba S, Tsujita H, Kobayashi Y, Daida H.
    • Journal Title

      Int Heart J.

      Volume: 56 Pages: 597-604

    • NAID

      130005113055

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Incremental prognostic value of coronary computed tomographic angiography high-risk plaque characteristics in newly symptomatic patients.2015

    • Author(s)
      Fujimoto S, Kondo T, Takamura K, Baber U, Shinozaki T, Nishizaki Y, Kawaguchi Y, Matsumori R, Hiki M, Miyauchi K, Daida H, Hecht H, Stone GW, Narula J.
    • Journal Title

      J Cardiol.

      Volume: 15 Pages: 241-5

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Presentation] 剖検例におけるLabeling methodによる新しいプラーク性状解析ソフトの有用性に関する検討.2017

    • Author(s)
      高村和久、藤本進一郎、比企誠、川口裕子、加藤悦郎、隈丸加奈子、代田浩之
    • Organizer
      第27回日本心血管画像動態学会
    • Place of Presentation
      津
    • Year and Date
      2017-01-20
    • Related Report
      2016 Research-status Report
  • [Presentation] 冠動脈FFR-CTの有効性2017

    • Author(s)
      藤本進一郎
    • Organizer
      第31回日本冠疾患学会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Usefulness of New Plaque Characteristics Analysis Software Employing the Labeling Method for Autopsy Cases.2017

    • Author(s)
      Takamura K, Fujimoto S, Kawaguchi Y, Hiki M, Kato E, Aoshima C, Kumamaru K, Daida H.
    • Organizer
      SCCT 2017 12th Annual Scientific meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The Predictive Factors Affecting Diagnostic Accuracy in On-Site Operated Novel CT-Fractional Flow Reserve Based on Fluid and Structural Interaction.2017

    • Author(s)
      Kawaguchi Y, Fujimoto S, Kawasaki T, Kumamaru KK, Dohi T, Kato E, Aoshima C, Takamura K, Kato Y, Hiki M, Okazaki S, Rybicki FJ, Daida H.
    • Organizer
      90th Scientific Session AHA
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The Predictive Factors Affecting Diagnostic Performance on Novel CT-Fractional Flow Reserve Based on Fluid Structual Interaction.2017

    • Author(s)
      Kawaguchi Y, Fujimoto S, Kumamaru K, Dohi T, Ri K, Yamada S, Takamura K, Kato E, Hiki M, Kato Y, Okazaki S, Daida H.
    • Organizer
      SCCT 2017 12th Annual Scientific meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Usefulness of Novel Plaque Characteristics Analysis Software Employing the Labeling Method in Autopsy Cases.2017

    • Author(s)
      Takamura K, Fujimoto S, Katou E, Kawaguchi Y, Hiki M, Kumamaru K, Daida H.
    • Organizer
      The 81th Annual Scientific Meeting of the Japanese Circulation Society
    • Related Report
      2017 Annual Research Report
  • [Presentation] The usefulness of low radiation dose subtraction coronary CT angiography for patients with calcification using 320 ADCT.2016

    • Author(s)
      高村 和久、藤本進一郎、比企 誠、川口 裕子、加藤 悦郎、青島 千紘、隈丸 加奈子、代田 浩之
    • Organizer
      第64回日本心臓病学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2016-09-23
    • Related Report
      2016 Research-status Report
  • [Presentation] 進化する臨床心臓病学2016

    • Author(s)
      代田浩之
    • Organizer
      第64回日本心臓病学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2016-09-23
    • Related Report
      2016 Research-status Report
  • [Presentation] 心臓リハビリテーションのエビデンズと現状の狭間で2016

    • Author(s)
      代田浩之
    • Organizer
      第22回日本心臓リハビリテーション学術集会
    • Place of Presentation
      東京
    • Year and Date
      2016-07-16
    • Related Report
      2016 Research-status Report
  • [Presentation] Development of comprehensive plaque evaluation by coronary CT angiography.2016

    • Author(s)
      藤本 進一郎、高村和久、川口 裕子、加藤 悦郎、比企 誠、土肥 智貴、隈丸 加奈子、代田浩之
    • Organizer
      第48回日本動脈硬化学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2016-07-06
    • Related Report
      2016 Research-status Report
  • [Presentation] Incremental prognostic value of coronary computed tomographic angiography high risk plaque characteristics in asymptomatic patients.2016

    • Author(s)
      Takamura K, Fujimoto S, Kondo T, Hiki M, Matsumori R, Kawaguchi Y, Suda S, Kato E, Kumamaru K, Takase S, Daida H.
    • Organizer
      The American College of Cardiology 65nd Annual Scientific Session
    • Place of Presentation
      USA,シカゴ
    • Year and Date
      2016-04-02
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] The Usefulness of Low Radiation Dose Subtraction Coronary CT Angiography for Coronary Segments with Calcification and Stent.2016

    • Author(s)
      Kazuhisa Takamura, Shinichiro Fujimoto, Makoto Hiki, Rie Matshmori, Yuuko Kawaguchi, Shoko Suda , Etsuro Kato, Kanako Kumamaru, Hiroyuki Daida
    • Organizer
      第80回日本循環器学会学術集会
    • Place of Presentation
      仙台
    • Year and Date
      2016-03-18
    • Related Report
      2015 Research-status Report
  • [Presentation] Submillisievert Imaging Protocol Using Full Reconstruction and Advanced Patient Motion Correction in 320-row Area Detector CT Angiography.2016

    • Author(s)
      Yuko Kawaguchi, Shinichiro Fujimoto, Shoko Suda, Etsuro Kato, Rie Matsumori, Kazuhisa Takamura, Makoto Hiki, Kanako Kumamaru, Hiroyuki Daida
    • Organizer
      第80回日本循環器学会学術集会
    • Place of Presentation
      仙台
    • Year and Date
      2016-03-18
    • Related Report
      2015 Research-status Report
  • [Presentation] Retrospective Evaluation of CT Angiography Transluminal Attenuation Gradient for the Detection of Compromised Fractional Flow Reserve.2016

    • Author(s)
      Etsuro Kato, Shinichiro Fujimoto, Yuko Kawaguchi, Rie Matsumori, Kazuhisa Takamura, Katsumi Miyauchi, Sweatkar Rani, Agarwal Mukta, Giannopoulos Andreas, Kanako Kumamaru, Rybicki Frank, Hiroyuki Daida
    • Organizer
      第80回日本循環器学会学術集会
    • Place of Presentation
      仙台
    • Year and Date
      2016-03-18
    • Related Report
      2015 Research-status Report
  • [Presentation] 糖尿病合併冠動脈疾患の診断と治療2016

    • Author(s)
      代田浩之
    • Organizer
      第50回糖尿病学の進歩
    • Place of Presentation
      東京
    • Year and Date
      2016-02-19
    • Related Report
      2015 Research-status Report
  • [Presentation] ガイドラインはどの方向に向かうのか2016

    • Author(s)
      代田浩之
    • Organizer
      第16回動脈硬化フォーラム
    • Place of Presentation
      東京
    • Year and Date
      2016-02-07
    • Related Report
      2015 Research-status Report
  • [Presentation] 高度石灰化症例における低被ばくSubtraction Coronary CTAの有効性の検討2016

    • Author(s)
      川口 裕子、藤本 進一郎、高村 和久、比企 誠、須田 翔子、加藤 悦郎、石浦 純子、隈丸 加奈子、代田 浩之
    • Organizer
      第26回日本心血管画像動態学会
    • Place of Presentation
      東京
    • Year and Date
      2016-01-29
    • Related Report
      2015 Research-status Report
  • [Presentation] 心血管疾患予防におけるω3系脂肪酸の臨床的有用性2015

    • Author(s)
      代田浩之
    • Organizer
      第13回日本機能性食品医用学会
    • Place of Presentation
      福岡
    • Year and Date
      2015-12-13
    • Related Report
      2015 Research-status Report
  • [Presentation] Prognostic Value of Coronary CT Angiography and Coronary Artery Calcium Score Performed Before Revascularization.2015

    • Author(s)
      Takamura: K, Fujimoto S, Kondo T, Kumamaru K, Kawaguchi Y, Suda S, Matsumori R., Kato E, Hiki M, Takase S, Rybicki FJ, Daida H.
    • Organizer
      American Heart Association, 88th Scientific Session
    • Place of Presentation
      Orland (USA)
    • Year and Date
      2015-11-07
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Residual risks for diabetic patients with coronary artery disease2015

    • Author(s)
      代田浩之
    • Organizer
      the 59th Annual Scientific Meeting of The Korean Society of Cardiology
    • Place of Presentation
      Goyang(韓国)
    • Year and Date
      2015-10-16
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] プラーク退縮と安定化を目指した積極的脂質低下療法の意義2015

    • Author(s)
      代田浩之
    • Organizer
      日本内科学会第53回信越支部生涯教育講演会
    • Place of Presentation
      新潟
    • Year and Date
      2015-10-11
    • Related Report
      2015 Research-status Report
  • [Presentation] Lipid management guideline in US and Japan2015

    • Author(s)
      代田浩之
    • Organizer
      第63回日本心臓病学会
    • Place of Presentation
      横浜
    • Year and Date
      2015-09-19
    • Related Report
      2015 Research-status Report
  • [Presentation] 高度石灰化、冠動脈ステント留置症例における、低電圧Subtraction Coronary CTAの初期検討2015

    • Author(s)
      高村 和久、藤本 進一郎、比企 誠、松森 理枝、川口 裕子、須田 翔子、加藤 悦郎、代田 浩之
    • Organizer
      第63回日本心臓病学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2015-09-18
    • Related Report
      2015 Research-status Report
  • [Presentation] Current state and future directions of cardiac rehabilitation in Japan我が国における心臓リハビリテーションの現状と今後の展望2015

    • Author(s)
      代田浩之
    • Organizer
      第2回国際スポートロジー学会
    • Place of Presentation
      東京
    • Year and Date
      2015-09-12
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Evaluation of 64-Multidetector Row CT Angiography Transluminal Attenuation Gradient for the Detection of Significant Coronary Artery Disease Determined by Fractional Flow Reserve.2015

    • Author(s)
      加藤 悦郎、藤本 進一郎、松森 理枝、Rani Bhivasankar 、Kanako K.Kumamaru 、川口 裕子、高村 和久、Frank J Rybicki 、Dimitrios Mitsouras 、宮内 克己、代田 浩之
    • Organizer
      第24回日本心血管インターベンション学会
    • Place of Presentation
      福岡
    • Year and Date
      2015-07-30
    • Related Report
      2015 Research-status Report
  • [Presentation] 冠動脈疾患予防のための包括的リスク管理の重要性2015

    • Author(s)
      代田浩之
    • Organizer
      青森臨床内科医会
    • Place of Presentation
      青森
    • Year and Date
      2015-07-24
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 心肺運動負荷試験を行うために必要な基礎 虚血性心疾患2015

    • Author(s)
      横山美帆
    • Organizer
      第21回日本心臓リハビリテーション学会学術大会
    • Place of Presentation
      福岡
    • Year and Date
      2015-07-18
    • Related Report
      2015 Research-status Report
  • [Presentation] 動脈硬化の概念と非観血的検査法2015

    • Author(s)
      代田浩之
    • Organizer
      第47回日本動脈硬化学会
    • Place of Presentation
      仙台
    • Year and Date
      2015-07-09
    • Related Report
      2015 Research-status Report
  • [Presentation] 心血管運動療法のあゆみと展望2015

    • Author(s)
      代田浩之
    • Organizer
      第50回日本理学療法学会
    • Place of Presentation
      東京
    • Year and Date
      2015-06-06
    • Related Report
      2015 Research-status Report
  • [Book] 循環器疾患最新の治療 2016-20172016

    • Author(s)
      代田浩之、横山美帆
    • Total Pages
      626
    • Publisher
      南江堂
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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