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Blockade of TRPC6/3 is a Novel Therapeutic Approach Against Pulmonary Arterial Hypertension

Research Project

Project/Area Number 15K09137
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Cardiovascular medicine
Research InstitutionKyoto University

Principal Investigator

Kinoshita Hideyuki  京都大学, 医学研究科, 特定准教授 (30467477)

Co-Investigator(Kenkyū-buntansha) 桑原 宏一郎  信州大学, 学術研究院医学系, 教授 (30402887)
Co-Investigator(Renkei-kenkyūsha) Mori Yasuo  京都大学, 大学院工学研究科, 教授 (80212265)
Nishida Motohiro  大学共同利用機関法人自然科学研究機構, 心臓シグナル研究部門, 教授 (90342641)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords肺動脈性肺高血圧症 / 心不全 / 肺血管リモデリング / 受容体活性化型Ca2+チャネル / 肺高血圧症
Outline of Final Research Achievements

In this study, we examined the role of transient receptor potential subfamily C (TRPC) 6/3 in pulmonary artreial hypertension. In mice and rat model of pulmonary hypertension, blockade of TRPC6/3 significantly inhibited elevation of pulmonary arterial pressure and right ventricular hypertrophy. These results suggest that Blockade of TRPC6/3 could be an novel therapeutic strategy for preventing pulmonary arterial hypertension.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (23 results)

All 2018 2017 2016 2015

All Journal Article (3 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 3 results,  Open Access: 3 results,  Acknowledgement Compliant: 1 results) Presentation (19 results) (of which Invited: 3 results) Book (1 results)

  • [Journal Article] EXPRESS: Rare variants in RNF213, a susceptibility gene for moyamoya disease, are found in patients with pulmonary hypertension and aggravate hypoxia-induced pulmonary hypertension in mice2018

    • Author(s)
      Kobayashi Hatasu、Kabata Risako、Kinoshita Hideyuki、Morimoto Takaaki、Ono Koh、Takeda Midori、Choi Jungmi、Okuda Hiroko、Liu Wanyang、Harada Kouji H、Kimura Takeshi、Youssefian Shohab、Koizumi Akio
    • Journal Title

      Pulmonary Circulation

      Volume: - Issue: 3 Pages: 204589401877815-204589401877815

    • DOI

      10.1177/2045894018778155

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Endothelium-derived C-type natriuretic peptide contributes to blood pressure regulation by maintaining endothelial integrity.2017

    • Author(s)
      Nakao K, Kuwahara K, Nishikimi T, Nakagawa Y, Kinoshita H, Minami T, Kuwabara Y, Yamada C, Yamada Y, Tokudome T, Nagai-Okatani C, Minamino N, Nakao YM, Yasuno S, Ueshima K, Sone M, Kimura T, Kangawa K, Nakao K
    • Journal Title

      Hypertension.

      Volume: 69 Issue: 2 Pages: 286-296

    • DOI

      10.1161/hypertensionaha.116.08219

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] 2.Outcomes of various transplant procedures (single, sparing, inverted) in living-donor lobar lung transplantation.2016

    • Author(s)
      Date H, Aoyama A, Hijiya K, Motoyama H, Handa T, Kinoshita H, Baba S, Mizota T, Minakata K, Chen-Yoshikawa TF
    • Journal Title

      J Thorac Cardiovasc Surgery

      Volume: 144 Pages: 710-715

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Prediction of Poor Outcome after PAH Targeted Therapy in Pulmonary Arterial Hypertension Patients with Lung Disease2017

    • Author(s)
      H. Kinoshita , T. Fujita , T. Handa , H. Yanagisawa , K moriuchi, H. Inazumi , N Saito, Y. Nakagawa , Kuwahara , K. Ono , T. Kimura
    • Organizer
      第81回日本循環器学会学術集会
    • Place of Presentation
      金沢
    • Year and Date
      2017-03-17
    • Related Report
      2016 Research-status Report
  • [Presentation] Prediction of Poor Outcome after PAH Targeted Therapy in Pulmonary Arterial Hypertension Patients with Lung Disease2017

    • Author(s)
      H. Kinoshita , T. Fujita , T. Handa , H. Yanagisawa , K moriuchi, H. Inazumi , N Saito, Y. Nakagawa , Kuwahara , K. Ono , T. Kimura
    • Organizer
      第81回日本循環器学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 肺高血圧症治療が変わる ~セレキシパグの可能性を踏まえて~2017

    • Author(s)
      木下秀之
    • Organizer
      第61回 日本リウマチ学会総会・学術集会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 呼吸器疾患を合併した肺動脈性肺高血圧症2017

    • Author(s)
      木下秀之
    • Organizer
      第57回日本呼吸器学会学術講演会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Clinical features of the Systemic Sclerosis associated Pulmonary Arterial Hypertension with Left Heart Disease2017

    • Author(s)
      柳澤洋、木下秀之、桑原宏一郎、吉藤元、森内健史、稲住英明、斎藤成達、中川靖章、尾野亘、木村剛
    • Organizer
      第21回日本心不全学会学術集会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 肺高血圧症治療の新たな展望~PGI2を考える~2016

    • Author(s)
      木下秀之
    • Organizer
      第20回日本新血管内分泌代謝学会学術集会、第33回国際心臓研究学会日本部会、第20回日本適応医学会学術集会 合同集会
    • Place of Presentation
      東京
    • Year and Date
      2016-12-16
    • Related Report
      2016 Research-status Report
  • [Presentation] 維持血液透析患者における肺高血圧症合併頻度とその臨床的特徴2016

    • Author(s)
      家村知樹, 木下秀之, 齋藤成達, 柳澤洋, 森内健史、稲住英明、中川靖章, 桑原宏一郎, 尾野亘, 木村剛
    • Organizer
      第1回日本肺高血圧・肺循環学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2016-10-01
    • Related Report
      2016 Research-status Report
  • [Presentation] 脳死肺移植術後にPGI2を漸減し心機能を評価したIPAHの1例2016

    • Author(s)
      米田智也, 木下秀之, 中島康弘, 本山秀樹, 土屋恭子, 青山晃博, 陳豊史, 桑原宏一郎, 木村剛, 伊達洋至, 一山智
    • Organizer
      第1回日本肺高血圧・肺循環学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2016-10-01
    • Related Report
      2016 Research-status Report
  • [Presentation] 肺移植待機中の肺動脈性肺高血圧症患者における予後予測指標の検討2016

    • Author(s)
      山上新太郎, 木下秀之, 本山秀樹, 土屋恭子, 青山晃博, 陳豊史, 中川靖章, 桑原宏一郎, 伊達洋至, 木村剛
    • Organizer
      第1回日本肺高血圧・肺循環学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2016-10-01
    • Related Report
      2016 Research-status Report
  • [Presentation] 肺血管拡張薬を投与した透析関連肺高血圧症の1症例の報告と、当院の透析患者における心エコーによる肺高血圧症症例の特徴2016

    • Author(s)
      家村知樹、木下秀之、山田千夏、辰島正二郎、渡部宏俊、中川靖章、静田聡、桑原宏一郎、尾野亘、木村剛
    • Organizer
      第113回 日本内科学会総会
    • Place of Presentation
      東京
    • Year and Date
      2016-04-15
    • Related Report
      2016 Research-status Report
  • [Presentation] Survival prospects of Patients with Pulmonary Artery Hypertension Referred for Lung Transplantation2016

    • Author(s)
      Shintaro Yamabgami, Hideyuki Kinoshita, Hideki Motoyama, Kyoko Hijiya, Akihiro Aoyama, Yoyofimi Chin, Akira Tshujimura, Hiromu Yanagisawa, Chinatsu Yamada, Takeru Makiyama, Yasuaki Nakagawa, Satoshi Shizuta, Koichiro Kuwahara, Koh Ono, Hiroshi Date, Takeshi Kimura
    • Organizer
      第80回日本循環器学会学術集会
    • Place of Presentation
      仙台
    • Year and Date
      2016-03-19
    • Related Report
      2015 Research-status Report
  • [Presentation] Pulmonary Edema in Patients with Connective Tissue Disease-Associated Pulmonary Arterial Hypertension receiving Pulmonary Vasodilator Therapies2016

    • Author(s)
      Hideyuki Kinoshita, Koichiro Kuwahara, Hiromu Yanagisawa, Hajime Yoshifuji, Chinatsu Yamada, Yoshihiro Kuwabara, Yasuaki Nakagawa, Takeru Makiyama, Satoshi Shizuta, Koh Ono, Takesyi Kimura
    • Organizer
      第80回日本循環器学会学術集会
    • Place of Presentation
      仙台
    • Year and Date
      2016-03-19
    • Related Report
      2015 Research-status Report
  • [Presentation] Guideline of the treatment of CTEPH2016

    • Author(s)
      木下秀之
    • Organizer
      Complex Cardiovascular Therapeutics 2016
    • Place of Presentation
      神戸
    • Related Report
      2016 Research-status Report
  • [Presentation] CTEPHに対する経皮的肺動脈拡張術(BPA)と薬物治療の治療効果の比較検討2016

    • Author(s)
      木下秀之
    • Organizer
      Complex Cardiovascular Therapeutics 2016
    • Place of Presentation
      神戸
    • Related Report
      2016 Research-status Report
  • [Presentation] HRCTにて肺静脈病変合併が示唆されるCTD-PAHに対する肺血管拡張療法の効果2015

    • Author(s)
      柳澤洋、木下秀之、吉藤元、半田知宏、藤井隆夫、牧山武、中川靖章、静田聡、桑原宏一郎、三森経世、木村剛
    • Organizer
      第4回日本肺循環学会(JPCS)第3回日本肺高血圧学会(JPHS)合同学術集
    • Place of Presentation
      ステーションコンファレンス東京、東京
    • Year and Date
      2015-10-03
    • Related Report
      2015 Research-status Report
  • [Presentation] 当院におけるILD-PHに対する肺血管拡張療法の効果の検討2015

    • Author(s)
      藤田啓誠、木下秀之、半田知宏,谷澤公伸、室繁郎、佐藤晋、山田千夏、中川靖章、静田聡、桑原宏一郎、木村剛
    • Organizer
      第4回日本肺循環学会(JPCS)第3回日本肺高血圧学会(JPHS)合同学術集
    • Place of Presentation
      ステーションコンファレンス東京、東京
    • Year and Date
      2015-10-03
    • Related Report
      2015 Research-status Report
  • [Presentation] 重症PAHにおける肺移植術後急性期の右室および左室機能の検討2015

    • Author(s)
      米田智也、木下秀之、中島康弘、本山秀樹、土屋恭子、青山晃博、陳豊史、桑原宏一郎、木村剛、伊達洋至、一山智
    • Organizer
      第4回日本肺循環学会(JPCS)第3回日本肺高血圧学会(JPHS)合同学術集
    • Place of Presentation
      ステーションコンファレンス東京、東京
    • Year and Date
      2015-10-03
    • Related Report
      2015 Research-status Report
  • [Presentation] 著明な低酸素血症を認めた重症特発性肺動脈性肺高血圧症の1症例2015

    • Author(s)
      相澤卓範、木下秀之、中西直彦、今井逸雄、牧山武、中川靖章、静田聡、桑原宏一郎、青山晃博、伊達洋至、木村剛
    • Organizer
      第4回日本肺循環学会(JPCS)第3回日本肺高血圧学会(JPHS)合同学術集
    • Place of Presentation
      ステーションコンファレンス東京、東京
    • Year and Date
      2015-10-03
    • Related Report
      2015 Research-status Report
  • [Presentation] 肺高血圧症の最新治療戦略 -病態に応じた治療法の選択-2015

    • Author(s)
      木下秀之
    • Organizer
      第79回日本循環器学会学術集会
    • Place of Presentation
      大阪国際会議場、大阪
    • Year and Date
      2015-04-24
    • Related Report
      2015 Research-status Report
  • [Book] 右心不全を識り評価して治療に活かす 右心不全・肺高血圧症治療に使用する薬剤一覧2015

    • Author(s)
      木下秀之
    • Total Pages
      6
    • Publisher
      文光堂
    • Related Report
      2015 Research-status Report

URL: 

Published: 2015-04-16   Modified: 2019-03-29  

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