| Project/Area Number |
15K09141
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cardiovascular medicine
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| Research Institution | Okayama University |
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Principal Investigator |
ITO Hiroshi 岡山大学, 医歯薬学総合研究科, 教授 (90446047)
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| Co-Investigator(Kenkyū-buntansha) |
中村 一文 岡山大学, 医歯薬学総合研究科, 准教授 (10335630)
三好 亨 岡山大学, 大学病院, 講師 (70444651)
吉田 賢司 岡山大学, 医歯薬学総合研究科, 講師 (70532761)
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| Co-Investigator(Renkei-kenkyūsha) |
MARUYAMA Toru 熊本大学, 薬学部, 教授 (90423657)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 虚血プレコンディショニング / 造影剤腎症 / プレコンディショニング / エクソソーム / マイクロRNA / ischemic preconditioning / acute kidney injury / exosome / 虚血性プレコンディショニング / 急性腎障害 |
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| Outline of Final Research Achievements |
Remote ischemic preconditioning (RIPC) is the phenomenon whereby brief episodes of ischemia-reperfusion applied in distant tissues or organs render the myocardial reperfusion injury. Recent clinical data showed RIPC is effective to contract induced nephropathy. This study evaluated the underlying mechanism on RIPC and found that circulating exosome was important for a mediator of RIPC. The microRNAs in exosomes were changed after RIPC. These finding suggest that further analysis of exosomes may provide novel therapy for contrast induced nephropathy.
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