Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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Outline of Final Research Achievements |
The heart causes myocardial remodeling as an adaptation to load. Although many cardiac hypertrophy inducers are already known, the mechanism of adaptive failure leading to heart failure has not been fully elucidated. We have previously shown that the cardiac stromal cell transcription factor KLF5 is important for load adaptation, and that acetylation of KLF5 is involved in cell proliferation in vitro. In this study, we focused on the acetylation of KLF5 molecule and DNA repair factor (ATM etc.) and clarified the role in adaptation and failure of the heart at individual level. It has been revealed that KLF5 non-acetylated mutant mice and ATM deficient mice produce abnormalities in cardiac development and hypertrophy. Furthermore, we isolated factors that interact with them and identified new therapeutic targets.
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