Molecular mechanisms underlying inflammasome-mediated cardiovascular disease

• Project/Area Number: 15K09146
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular medicine
• Research Institution: Jichi Medical University
• Principal Investigator: Takahashi Masafumi 自治医科大学, 医学部, 教授 (40296108)
• Co-Investigator(Kenkyū-buntansha): 臼井 文武 自治医科大学, 医学部, 助教 (50585560) ; 唐澤 直義 自治医科大学, 医学部, 助教 (60631893) ; 木村 博昭 自治医科大学, 医学部, 講師 (70593622) ; 渡邊 幸子 自治医科大学, 医学部, 助教 (80770619)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: サイトカイン / 炎症反応 / 心血管病 / タンパク質修飾

Outline of Final Research Achievements

NLRP3 inflammasome is a multiprotein complex that regulates IL-1β release and involved in sterile inflammatory responses. We investigated the role of NLRP3 inflammasome using mice deficient for NLRP3 inflammasome components and found the importance of NLRP3 inflammasome in abdominal aortic aneurysm, doxorubicin-induced cardiotoxicity, and pregnancy hypertension. Furthermore, we identified an ARIH2 as an interacting molecule with NLRP3 and found that ARIH2 directly ubiquitinates NLRP3 and negatively regulates its activation. These findings suggest that NLRP3 inflammasome is a key player in the pathophysiology of cardiovascular disease and a better understanding of the mechanism that underlies NLRP3 inflammasome will offer new therapeutic modalities in the disease.

Research Products

• [Journal Article] Saturated Fatty Acids Undergo Intracellular Crystallization and Activate the NLRP3 Inflammasome in MacrophagesHighlights (2018)
  • Author(s): Karasawa Tadayoshi、Kawashima Akira、Usui-Kawanishi Fumitake、Watanabe Sachiko、Kimura Hiroaki、Kamata Ryo、Shirasuna Koumei、Koyama Yutaro、Sato-Tomita Ayana、Matsuzaka Takashi、Tomoda Hiroshi、Park Sam-Yong、Shibayama Naoya、Shimano Hitoshi、Kasahara Tadashi、Takahashi Masafumi
  • Journal Title: Arteriosclerosis, Thrombosis, and Vascular Biology Volume: 38 Issue: 4 Pages: 744-756
  • DOI: 10.1161/atvbaha.117.310581
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The crystal-induced activation of NLRP3 inflammasomes in atherosclerosis. (2017)
  • Author(s): Karasawa T, Takahashi M.
  • Journal Title: Inflammation and Regeneration Volume: 37 Issue: 1 Pages: 18-18
  • DOI: 10.1186/s41232-017-0050-9
  • Peer Reviewed / Open Access
• [Journal Article] ARIH2 Ubiquitinates NLRP3 and Negatively Regulates NLRP3 Inflammasome Activation in Macrophages (2017)
  • Author(s): Kawashima Akira、Karasawa Tadayoshi、Tago Kenji、Kimura Hiroaki、Kamata Ryo、Usui-Kawanishi Fumitake、Watanabe Sachiko、Ohta Satoshi、Funakoshi-Tago Megumi、Yanagisawa Ken、Kasahara Tadashi、Suzuki Koichi、Takahashi Masafumi
  • Journal Title: The Journal of Immunology Volume: 199 Issue: 10 Pages: 3614-3622
  • DOI: 10.4049/jimmunol.1700184
  • Peer Reviewed / Open Access
• [Journal Article] Interaction of Neutrophils with Macrophages Promotes IL-1β Maturation and Contributes to Hepatic Ischemia?Reperfusion Injury (2017)
  • Author(s): Sadatomo Ai、Inoue Yoshiyuki、Ito Homare、Karasawa Tadayoshi、Kimura Hiroaki、Watanabe Sachiko、Mizushina Yoshiko、Nakamura Jun、Kamata Ryo、Kasahara Tadashi、Horie Hisanaga、Sata Naohiro、Takahashi Masafumi
  • Journal Title: The Journal of Immunology Volume: 199 Issue: 9 Pages: 3306-3315
  • DOI: 10.4049/jimmunol.1700717
  • Peer Reviewed
• [Journal Article] The cardiac glycoside ouabain activates NLRP3 inflammasomes and promotes cardiac inflammation and dysfunction (2017)
  • Author(s): Kobayashi Motoi、Usui-Kawanishi Fumitake、Karasawa Tadayoshi、Kimura Hiroaki、Watanabe Sachiko、Mise Nathan、Kayama Fujio、Kasahara Tadashi、Hasebe Naoyuki、Takahashi Masafumi
  • Journal Title: PLOS ONE Volume: 12 Issue: 5 Pages: 176676-176676
  • DOI: 10.1371/journal.pone.0176676
  • Peer Reviewed / Open Access
• [Journal Article] Role of NLRP3 Inflammasomes in Atherosclerosis (2017)
  • Author(s): Karasawa, T.,Takahashi, M
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 24 Issue: 5 Pages: 443-451
  • DOI: 10.5551/jat.RV17001
  • NAID: 130005631688
  • ISSN: 1340-3478, 1880-3873
  • Peer Reviewed
• [Journal Article] Infiltration of M1, but not M2, macrophages is impaired after unilateral ureter obstruction in Nrf2-deficient mice. (2017)
  • Author(s): Sogawa Y, Nagasu H, Iwae S, Ihoriya C, Itano S, Uchida A, Kidokoro K, Taniguchi S, Takahashi M, Satoh M, Sasaki T, Suzuki T, Yamamoto M, Horng T and Kashihara N.
  • Journal Title: Scientific Reports Volume: 7 Issue: 1 Pages: 8801-8801
  • DOI: 10.1038/s41598-017-08054-2
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The origin and distribution of CD68, CD163 and alpha SMA positive cells in the early phase after meniscal resection in a parabiotic rat model. (2017)
  • Author(s): Terai S, Hashimoto Y, Orita K, Yamasaki S, Takigami J, Shinkuma T, Teraoka T, Nishida Y, Takahashi M, Nakamura H.
  • Journal Title: Connect Tissue Res Volume: 6 Issue: 6 Pages: 1-11
  • DOI: 10.1080/03008207.2017.1284825
  • Peer Reviewed
• [Journal Article] Caspse-1 deficiency promotes high-fat diet-induced adipose tissue inflammation and the development of obesity. (2016)
  • Author(s): Kimura H, Karasawa T, Usui F, Kawashima A, Endo Y, Kobayashi M, Sadatomo A, Nakamura J, Iwasaki Y, T Yada,Tsutsui H, Kasahara T, Takahashi M.
  • Journal Title: Am J Physiol Endocrinol Metab Volume: 311 Issue: 5 Pages: 881-890
  • DOI: 10.1152/ajpendo.00174.2016
  • Peer Reviewed
• [Journal Article] NLRP3 reduces macrophage interleukin-10 production and enhances the susceptibility to doxorubicin-induced cardiotoxicity. (2016)
  • Author(s): Kobayashi M, Usui F, Karasawa T, Kawashima A, Kimura H, Mizushina Y, Shirasuna K, Mizukami H, Kasahara T, Hasebe N, Takahashi M.
  • Journal Title: Sci Rep Volume: 6 Issue: 1 Pages: 26489-26489
  • DOI: 10.1038/srep26489
  • Peer Reviewed / Open Access
• [Journal Article] Involvement of a pro-apoptotic gene BBC3 in islet injury mediated by cold preservation and re-warming. (2016)
  • Author(s): Omori K, Kobayashi E, Komatsu H, J Rawson, Agrawal G, Parimi M, Oancea A, Valiente L, Ferreri K, Al-Abdullah IS, Kandeel F, Takahashi M, Mullen Y.
  • Journal Title: Am J Physiol Endocrinol Metab Volume: 310 Issue: 11 Pages: E1016-E1026
  • DOI: 10.1152/ajpendo.00441.2015
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Palmitic acid induces interleukin-1beta secretion via NLRP3 inflammasomes and inflammatory responses through ROS production in human placental cells. (2016)
  • Author(s): Shirasuna K, Takano T, Seno K, Ohtsu A, Karasawa T, Takahashi M, Ohkuchi A, Suzuki H, Matsubara S, Iwata H, Kuwayama T.
  • Journal Title: J Reprod Immunol Volume: 116 Pages: 104-112
  • DOI: 10.1016/j.jri.2016.06.001
  • Peer Reviewed
• [Journal Article] Mechanisms of islet damage mediated by pancreas cold ischemia/rewarming. (2016)
  • Author(s): Omori K, Kobayashi E, Jeffrey R, Takahashi M, Mullen Y.
  • Journal Title: Cyobiology Volume: 73 Issue: 2 Pages: 126-134
  • DOI: 10.1016/j.cryobiol.2016.08.010
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Immunoproteasome LMP7 deficiency improves obesity and metabolic disorders. (2015)
  • Author(s): Kimura H, Usui F, Karasawa T, Kawashima A, Shirasuna K, Inoue Y, Komada T, Kobayashi M, Mizushina Y, Kasahara T, Suzuki K, Iwasaki Y, Yada T, Caturegli P, Takahashi M.
  • Journal Title: Scientific Reports Volume: 5 Issue: 1 Pages: 15883-15883
  • DOI: 10.1038/srep15883
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] NLRP3 deficiency improves angiotensin II-induced hypertension but not fetal growth restriction during pregnancy. (2015)
  • Author(s): Shirasuna K, Karasawa T, Usui F, Kobayashi M, Komada T, Kimura A, Ohkuchi A, Taniguchi S, Takahashi M.
  • Journal Title: Endocrinology Volume: 156 Issue: 11 Pages: 4281-4292
  • DOI: 10.1210/en.2015-1408
  • Peer Reviewed / Open Access
• [Journal Article] Role of NLRP3 inflammasomes for rhabdomyolysis-induced acute kidney injury. (2015)
  • Author(s): Komada T, Usui F, Kawashima A, Kimura H, Karasawa T, Inoue Y, Kobayashi M, Mizushina Y, Kasahara T, Taniguchi S, Muto S, Nagata D, Takahashi M.
  • Journal Title: Scientific Reports Volume: 5 Issue: 1 Pages: 10901-10901
  • DOI: 10.1038/srep10901
  • Peer Reviewed / Open Access
• [Journal Article] Oligomerized CARD16 Promotes Caspase-1 Assembly and IL-1β Processing (2015)
  • Author(s): Tadayoshi Karasawa, Akira Kawashima, Fumitake Usui, Hiroaki Kimura, Koumei Shirasuna, Yoshiyuki Inoue, Takanori Komada, Motoi Kobayashi, Yoshiko Mizushina, Junji Sagara, Masafumi Takahashi
  • Journal Title: FEBS Open Bio Volume: 5 Issue: 1 Pages: 348-356
  • DOI: 10.1016/j.fob.2015.04.011
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] NLRP3 protein deficiency exacerbates hyperoxia-induced lethality through Stat3 protein signaling independent of interleukin-1β (2015)
  • Author(s): Mizushina Y, Shirasuna K, Usui F, Karasawa T, Kawashima A, Kimura H, Kobayashi M, Komada T, Inoue Y, Mato N, Yamasawa H, Latz E, Iwakura Y, Kasahara T, Bando M, Sugiyama Y, Takahashi M
  • Journal Title: J Biol Chem Volume: 290 Issue: 8 Pages: 5065-5077
  • DOI: 10.1074/jbc.m114.603217
  • Peer Reviewed / Open Access
• [Journal Article] Letter regarding article “Inhibition of interleukin-1beta decrease aneurysm formation and progression in murine model of thoracic aortic aneurysm”. (2015)
  • Author(s): Usui F, Kobayashi M, Takahashi M.
  • Journal Title: Circulation Volume: 131 Issue: 14
  • DOI: 10.1161/circulationaha.114.013988
  • Peer Reviewed
• [Journal Article] Comment on “Radiation exposure induces inflammatory pathway activation in immune cells”. (2015)
  • Author(s): Inoue Y, Takahashi M.
  • Journal Title: The Journal of Immunology Volume: 194 Issue: 11 Pages: 5039-5039
  • DOI: 10.4049/jimmunol.1500381
  • Peer Reviewed
• [Journal Article] Letter regarding article “Anti-inflammatory and anti-atherogenic effects of the inflammasome NLRP3 inhibitor, arglabin, in ApoE2.Ki mice fed a high fat diet”. (2015)
  • Author(s): Karasawa T, Takahashi M.
  • Journal Title: Circulation Volume: 132 Issue: 21
  • DOI: 10.1161/circulationaha.115.016070
  • Peer Reviewed
• [Journal Article] Role of NLRP3 inflammasomes in hepatic ischemia-reperfusion injury. (2015)
  • Author(s): Inoue Y, Sadatomo A, Takahashi M.
  • Journal Title: Inflammation and Regeneration Volume: 35 Pages: 61-68
  • NAID: 130005063949
  • Peer Reviewed
• [Journal Article] New insights into the function of the immunoproteasome in immune and non-immune cells. (2015)
  • Author(s): Kimura H, Caturegli P, Takahashi M, Suzuki K.
  • Journal Title: Journal of Immunology Research Volume: 2015 Pages: 541984-541984
  • DOI: 10.1155/2015/541984
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] RIP140 as a novel therapeutic target in the treatment of atherosclerosis. (2015)
  • Author(s): Karasawa T, Takahashi M.
  • Journal Title: Journal of Molecular and Cellular Cardiology Volume: 81 Pages: 136-138
  • DOI: 10.1016/j.yjmcc.2015.02.009
  • Peer Reviewed
• [Journal Article] High-Mobility Group Box 1 Protein in Myocardial Infarction: Should it be Stimulated or Inhibited? (2015)
  • Author(s): Takahashi M.
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 22 Issue: 6 Pages: 553-554
  • DOI: 10.5551/jat.ED008
  • NAID: 130005078023
  • ISSN: 1340-3478, 1880-3873
  • Peer Reviewed
• [Journal Article] Transplantation of adipose tissue-derived stem cells improves cardiac contractile function and electrical stability in a rat myocardial infarction model. (2015)
  • Author(s): Gautam M., Fujita D., Kimura K., Ichikawa H., Izawa A., Hirose M., Kashihara T., Yamada M., Takahashi M., Ikeda U., Shiba Y.
  • Journal Title: Journal of molecular and cellular cardiology Volume: 81 Pages: 139-149
  • DOI: 10.1016/j.yjmcc.2015.02.012
  • Peer Reviewed / Open Access
• [Journal Article] Excess aldosterone is a critical danger signal for inflammasome activation in the development of renal fibrosis in mice. (2015)
  • Author(s): Kadoya H, Satoh M, Sasaki T, Taniguchi S, Takahashi M, Kashihara N.
  • Journal Title: FASEB J Volume: 29 Issue: 9 Pages: 3899-391
  • DOI: 10.1096/fj.15-271734
  • Peer Reviewed / Open Access
• [Journal Article] The frequency of peripheral blood CD4+Fox3+ regulatory T cells in women with preeclampsia and those with high risk factors for preeclampsia. (2015)
  • Author(s): Nagayama S, Ohkuchi A, Shirasuna K, Takahashi K, Suzuki H, Hirashima C, Sakata A, Nishimura S, Takahashi M, Matsubara S.
  • Journal Title: Hypertension in Pregnancy Volume: 34 Pages: 443-455
  • Peer Reviewed
• [Journal Article] Fate, origin and roles of cells within free bone grafts. (2015)
  • Author(s): Yano K, Yasuda H, Takaoka K, Takahashi M, Nakamura H, Imai Y, Wakitani S.
  • Journal Title: Journal of Orthopaedic Science Volume: 20 Issue: 2 Pages: 390-396
  • DOI: 10.1007/s00776-014-0673-5
  • Peer Reviewed
• [Journal Article] Inflammasome activation by mitochondrial oxidative stress in macrophages leads to the development of angiotensin II-induced aortic aneurysm (2014)
  • Author(s): Usui F, Shirasuna K, Kimura H, Tatsumi K, Kawashima A, Karasawa T, Yoshimura K, Aoki H, Tsutsui H, Noda T, Sagara J, Taniguchi S, Takahashi M
  • Journal Title: Arterioscler Thromb Vasc Biol Volume: 35 Issue: 1 Pages: 127-136
  • DOI: 10.1161/atvbaha.114.303763
  • Peer Reviewed / Open Access
• [Journal Article] Nanosilica-induced placental inflammation and pregnancy complications: Different roles of the inflammasome components NLRP3 and ASC. (2014)
  • Author(s): Shirasuna K, Usui F, Karasawa T, Kimura H, Kawashima A, Mizukami H, Ohkuchi A, Nishimura S, Sagara J, Noda T, Ozawa K, Taniguchi S, Takahashi M
  • Journal Title: Nanotoxicology Volume: 11 Issue: 5 Pages: 1-14
  • DOI: 10.3109/17435390.2014.956156
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] Contribution of the immunoproteasome to the inflammatory phenotype observed in obese mice. (2017)
  • Author(s): Kimura H, Karasawa T, Watanabe S, Suzuki K, Caturegli P, Takahashi M.
  • Organizer: IMMUNOLOGY2017
  • Int'l Joint Research
• [Presentation] 高脂肪食による肥満性炎症におけるCaspase-1の役割． (2017)
  • Author(s): 木村博昭、唐澤直義、岩崎有作、矢田俊彦、高橋将文．
  • Organizer: 第90回日本内分泌学会学術総会
• [Presentation] ドキソルビシン心筋傷害におけるインフラマソーム構成分子NLRP3の役割． (2017)
  • Author(s): 高橋将文、小林基、唐澤直義、渡邊幸子、木村博昭．
  • Organizer: 第38回日本炎症・再生医学会
• [Presentation] 高脂肪食誘導による肥満性炎症におけるCaspase-1の役割． (2017)
  • Author(s): 木村博昭、唐澤直義、渡邊幸子、笠原忠、高橋将文．
  • Organizer: 第38回日本炎症・再生医学会
• [Presentation] 飽和脂肪酸は結晶形成を介して好中球浸潤を誘導する． (2017)
  • Author(s): 唐澤直義、渡邊幸子、木村博昭、高橋将文．
  • Organizer: 第38回日本炎症・再生医学会
• [Presentation] 肝虚血再灌流障害におけるインフラマソーム非依存性IL-1β産生機構の解明． (2017)
  • Author(s): 佐田友藍、井上賢之、渡邊幸子、唐澤直義、木村博昭、佐田尚宏、高橋将文．
  • Organizer: 第38回日本炎症・再生医学会
• [Presentation] 無菌性炎症とインフラマソーム． (2016)
  • Author(s): 高橋将文．
  • Organizer: 第31回日本乾癬学会学術大会
  • Place of Presentation: ホテル東日本（栃木）
  • Year and Date: 2016-09-02
  • Invited
• [Presentation] 飽和脂肪酸によるインフラマソーム活性化機構の解析． (2016)
  • Author(s): 唐澤直義、臼井文武、川島晃、木村博昭、高橋将文．
  • Organizer: 第48回日本動脈硬化学会
  • Place of Presentation: 京王プラザホテル（東京）
  • Year and Date: 2016-07-14
• [Presentation] 横紋筋融解症による急性腎障害におけるNLRP3インフラマソームの役割． (2016)
  • Author(s): 高橋将文、駒田敬則、臼井文武、唐澤直義、川島晃、木村博昭．
  • Organizer: 第37回日本炎症・再生医学会
  • Place of Presentation: みやこめっせ（京都）
  • Year and Date: 2016-06-16
• [Presentation] 脂肪酸結晶によるNLRP3インフラマソームを介した炎症惹起機構の解析． (2016)
  • Author(s): 唐澤直義、臼井文武、川島晃、木村博昭、高橋将文．
  • Organizer: 第37回日本炎症・再生医学会
  • Place of Presentation: みやこめっせ（京都）
  • Year and Date: 2016-06-16
• [Presentation] 高脂肪食誘導型肥満における免疫プロテアソーム（LMP7）の役割． (2016)
  • Author(s): 木村博昭、唐澤直義、川島晃、臼井文武、笠原忠、鈴木幸一、高橋将文．
  • Organizer: 第37回日本炎症・再生医学会
  • Place of Presentation: みやこめっせ（京都）
  • Year and Date: 2016-06-16
• [Presentation] メタボリック病態における免疫プロテアソーム欠損の有益な効果． (2016)
  • Author(s): 木村博昭、臼井文武、唐澤直義、川島晃、笠原忠、鈴木幸一、岩﨑有作、矢田俊彦、高橋将文．
  • Organizer: 第89回日本内分泌学会学術総会
  • Place of Presentation: 国立京都国際会館（京都）
  • Year and Date: 2016-04-21
• [Presentation] 心血管病における無菌性炎症とインフラマソーム． (2016)
  • Author(s): 高橋将文．
  • Organizer: 第26回日本循環薬理学会
  • Place of Presentation: 信州大学（長野）
• [Presentation] 横紋筋融解症による急性腎障害におけるNLRP3インフラマソームの役割 (2015)
  • Author(s): 高橋将文、駒田敬則、臼井文武、川島晃、唐澤直義、木村博昭．
  • Organizer: 心血管抗加齢研究会2015
  • Place of Presentation: 梅田スカイビル（大阪市北区）
  • Year and Date: 2015-11-28
• [Presentation] The inflammasome in atherothrombosis. (2015)
  • Author(s): Takahashi, M.
  • Organizer: AHA Scientific Sessions 2015 Cardiovascular Seminar CVC.
  • Place of Presentation: Orlando, Florida (America)
  • Year and Date: 2015-11-07
  • Int'l Joint Research / Invited
• [Presentation] 心腎血管疾患における自然炎症の役割 (2015)
  • Author(s): 高橋将文．
  • Organizer: 第38回日本高血圧学会総会
  • Place of Presentation: 愛媛県県民文化会館（愛媛県松山市）
  • Year and Date: 2015-10-09
  • Invited
• [Presentation] 横紋筋融解症による急性腎障害におけるNLRP3インフラマソームの役割 (2015)
  • Author(s): 臼井文武、駒田敬則、唐澤直義、川島晃、木村博昭、武藤重明、長田太助、高橋将文．
  • Organizer: 第36回日本炎症・再生医学会
  • Place of Presentation: 虎ノ門ヒルズフォーラム（東京都港区）
  • Year and Date: 2015-07-21
• [Presentation] 脂質代謝異常におけるASCの役割 (2015)
  • Author(s): 唐澤直義、木村博昭、臼井文武、川島晃、高橋将文．
  • Organizer: 第36回日本炎症・再生医学会
  • Place of Presentation: 虎ノ門ヒルズフォーラム（東京都港区）
  • Year and Date: 2015-07-21
• [Presentation] 動脈硬化および大動脈瘤形成におけるNLRP3インフラマソームの役割 (2015)
  • Author(s): 臼井文武、木村博昭、唐澤直義、川島晃、谷口俊一郎、高橋将文．
  • Organizer: 第26回日本生体防御学会学術総会
  • Place of Presentation: 台東区生涯学習センター（東京都台東区）
  • Year and Date: 2015-07-10
• [Book] 日本臨床検査自動化学会会誌 (2015)
  • Author(s): 高橋将文
  • Publisher: （一社）日本臨床検査自動科学会
• [Book] 循環器内科 (2015)
  • Author(s): 小林基、高橋将文
  • Publisher: 科学評論社
• [Book] G.I.Research (2015)
  • Author(s): 井上賢之、高橋将文
  • Publisher: 先端医学社
• [Book] 疾患モデルの作製と利用：脂質代謝異常と関連疾患 (2015)
  • Author(s): 臼井文武、高橋将文
  • Publisher: エル・アイ・シー
• [Remarks] 自治医科大学 分子病態治療研究センター 炎症・免疫研究部
  • URL: http://www.jichi.ac.jp/inflammation/