| Project/Area Number |
15K09146
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cardiovascular medicine
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| Research Institution | Jichi Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
臼井 文武 自治医科大学, 医学部, 助教 (50585560)
唐澤 直義 自治医科大学, 医学部, 助教 (60631893)
木村 博昭 自治医科大学, 医学部, 講師 (70593622)
渡邊 幸子 自治医科大学, 医学部, 助教 (80770619)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | サイトカイン / 炎症反応 / 心血管病 / タンパク質修飾 |
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| Outline of Final Research Achievements |
NLRP3 inflammasome is a multiprotein complex that regulates IL-1β release and involved in sterile inflammatory responses. We investigated the role of NLRP3 inflammasome using mice deficient for NLRP3 inflammasome components and found the importance of NLRP3 inflammasome in abdominal aortic aneurysm, doxorubicin-induced cardiotoxicity, and pregnancy hypertension. Furthermore, we identified an ARIH2 as an interacting molecule with NLRP3 and found that ARIH2 directly ubiquitinates NLRP3 and negatively regulates its activation. These findings suggest that NLRP3 inflammasome is a key player in the pathophysiology of cardiovascular disease and a better understanding of the mechanism that underlies NLRP3 inflammasome will offer new therapeutic modalities in the disease.
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