| Project/Area Number |
15K09148
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cardiovascular medicine
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| Research Institution | Hyogo University of Health Sciences |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
内藤 由朗 兵庫医科大学, 医学部, 講師 (10446049)
増山 理 兵庫医科大学, 医学部, 教授 (70273670)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 慢性心不全 / 貧血 / 心腎貧血症候群 / インドキシル硫酸 / エリスロポエチン / 鉄 / 好中球リンパ球比 / 炎症 |
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| Outline of Final Research Achievements |
To elucidate the mechanisms of development of anemia and leukocyte abnormality in chronic heart failure, we performed animal experiments using Dahl salt-sensitive (DS) rats, in which high-salt diet induces hypertension, heart failure, anemia, and an increase in neutrophil/lymphocyte ratio (NLR). We found shortened half-life of red blood cell is the main cause of anemia in DS rats, and free hemoglobin released from red blood cell might cause renal damage. We also performed animal experiments using adenine-induced nephropathy model of mouse. We found elevated serum indoxyl sulfate induces increase in NLR by distortion of leukocyte hematopoiesis in bone marrow.
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