Visualization of leukocyte migration in diagnosis and development of atherosclerosis
| Project/Area Number |
15K09153
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cardiovascular medicine
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
OSAKA Mizuko 東京医科歯科大学, 統合研究機構, 助教 (00581711)
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| Co-Investigator(Kenkyū-buntansha) |
吉田 雅幸 東京医科歯科大学, 統合研究機構, 教授 (80282771)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Keywords | 血管炎症 / 白血球接着 / 内皮下浸潤 / 内在性白血球 / 白血球浸潤 / 生体内蛍光顕微鏡 |
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| Outline of Final Research Achievements |
We constructed new in vivo imaging system to observe process of leukocyte migration via adhesion on endothelium. This system did not capture the migration via adhesion, suggesting that increment of residual leukocytes may cause accumulation of leukocytes in intima. Furthermore, these leukocytes were positive for CD11b, CD11c, MHC class2, CCR2, CD40, CD80 and CD86 but not F4/80 and Ly6G, suggesting that residual leukocytes may be new cell type.
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Report
(4 results)
Research Products
(15 results)
