Investigation of the role of immunoinflammatory responses in atherosclerotic disease and development of novel immunotherapies
| Project/Area Number |
15K09156
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cardiovascular medicine
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| Research Institution | Kobe Pharmaceutical University (2017)
Kobe University (2015-2016) |
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Principal Investigator |
SASAKI NAOTO 神戸薬科大学, 薬学部, 准教授 (00514746)
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| Research Collaborator |
KASAHARA KAZUYUKI
EMOTO TAKUO
HAYASHI TOMOHIRO
MATSUMOTO TAKUYA 神戸大学, 医学研究科
MIZOGUCHI TAIJI 神戸薬科大学, 薬学部, 研究員 (40806882)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 動脈硬化 / 腹部大動脈瘤 / 炎症・免疫反応 |
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| Outline of Final Research Achievements |
Using atherosclerotic Foxp3+ regulatory T cell (Treg)-depleted mice, we provided direct evidence that Foxp3+ Tregs play a protective role in the development of atherosclerosis by regulating immunoinflammatory responses. Using atherosclerotic CTLA-4 (cytotoxic T lymphocyte antigen-4) transgenic mice, we demonstrated that CTLA-4 regulates atherosclerosis by suppressing pathogenic immune responses. We found that UVB irradiation reduced the development and related mortality of angiotensin II-induced abdominal aortic aneurysm in mice and that these protective effects were associated with systemic expansion of Foxp3+ Tregs and reduced inflammatory responses in aortic aneurysmal lesions.
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Report
(4 results)
Research Products
(35 results)
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[Journal Article] UVB exposure inhibits angiotensin II-induced abdominal aortic aneurysm formation in mice by expanding CD4+Foxp3+ regulatory T cells.2017
Author(s)
Hayashi T, Sasaki N, Yamashita T, Mizoguchi T, Emoto T, AminHZ, Yodoi K, Matsumoto T, Kasahara K, Yoshida N, Tabata T, Kitano N, Fukunaga A, Nishigori T, Rikitake Y, Hirata K.
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Journal Title
J Am Heart Assoc.
Volume: 6
Issue: 9
DOI
Related Report
Peer Reviewed
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[Journal Article] UVB Exposure Prevents Atherosclerosis by Regulating Immunoinflammatory Responses.2017
Author(s)
Sasaki, N., T. Yamashita, K. Kasahara, A. Fukunaga, T. Yamaguchi, T. Emoto, K. Yodoi, T. Matsumoto, K. Nakajima, T. Kita, M. Takeda, T. Mizoguchi, T. Hayashi, Y. Sasaki, M. Hatakeyama, K. Taguchi, K. Washio, S. Sakaguchi, B. Malissen, C. Nishigori, and K.I. Hirata
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Journal Title
Arterioscler Thromb Vasc Biol
Volume: 37(1)
Issue: 1
Pages: 66-74
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Overexpression of Cytotoxic T-Lymphocyte–Associated Antigen-4 Prevents Atherosclerosis in Mice2016
Author(s)
Takuya Matsumoto, Naoto Sasaki, Tomoya Yamashita, Takuo Emoto, Kazuyuki Kasahara, Taiji Mizoguchi, Tomohiro Hayashi, Keiko Yodoi, Naoki kitano, Takashi Saito, Tomoyuki Yamaguchi, and Ken-ichi Hirata
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Journal Title
Arterioscler Thromb Vasc Biol.
Volume: 36
Issue: 6
Pages: 1141-51
DOI
Related Report
Peer Reviewed / Open Access
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