| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
Using atherosclerotic Foxp3+ regulatory T cell (Treg)-depleted mice, we provided direct evidence that Foxp3+ Tregs play a protective role in the development of atherosclerosis by regulating immunoinflammatory responses. Using atherosclerotic CTLA-4 (cytotoxic T lymphocyte antigen-4) transgenic mice, we demonstrated that CTLA-4 regulates atherosclerosis by suppressing pathogenic immune responses. We found that UVB irradiation reduced the development and related mortality of angiotensin II-induced abdominal aortic aneurysm in mice and that these protective effects were associated with systemic expansion of Foxp3+ Tregs and reduced inflammatory responses in aortic aneurysmal lesions.
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