The role of integrin in the development of abdominal aortic aneurysm
| Project/Area Number |
15K09157
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cardiovascular medicine
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| Research Institution | Okayama University |
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Principal Investigator |
MIYOSHI Toru 岡山大学, 大学病院, 講師 (70444651)
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| Co-Investigator(Kenkyū-buntansha) |
中村 一文 岡山大学, 医歯薬学総合研究科, 准教授 (10335630)
米澤 朋子 岡山大学, 医歯薬学総合研究科, 助教 (30304299)
吉田 賢司 岡山大学, 医歯薬学総合研究科, 講師 (70532761)
伊藤 浩 岡山大学, 医歯薬学総合研究科, 教授 (90446047)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 腹部大動脈瘤 / 接着因子 / インテグリン / 細胞外マトリックス / integrin / extracellular matrix |
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| Outline of Final Research Achievements |
Abdominal aortic aneurysm is a silent disease, but lethal once ruptured. The prevention of AAA expansion and rupture is clinically difficult. This study investigated whether alpha1 integrin, an adhesion molecule, is involved in the development of AAA in murine model. Genetic deficiency of alpha1 integrin suppressed the rupture of AAA in angiotensin II infusion model. These findings suggest that alpha1 integrin may be a promising target to treat AAA.
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Report
(4 results)
Research Products
(8 results)
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[Journal Article] Comparable effect of aliskiren or a diuretic added on an angiotensin II receptor blocker on augmentation index in hypertension: a multicentre, prospective, randomised study.2017
Author(s)
Miyoshi T, Murakami T, Sakuragi S, Doi M, Nanba S, Mima A, Tominaga Y, Oka T,
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Journal Title
Open Heart.
Volume: ４
Issue: 1
Pages: e000591-e000591
DOI
Related Report
Peer Reviewed
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[Presentation] Remote ischemic preconditioning prevents contrast induced acute kidney injury in patients with stable coronary artery disease following elective PCI: results from the multicenter randomised study2017
Author(s)
H. Otsuka, T. Miyoshi, K. Ejiri, K. Kohno, M. Nakahama, M. Doi, M. Munemasa, M. Murakami, A. Takaishi, K. Nakamura, H. Ito
Organizer
ESC2017
Related Report
Int'l Joint Research
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