• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

The role of integrin in the development of abdominal aortic aneurysm

Research Project

Project/Area Number 15K09157
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Cardiovascular medicine
Research InstitutionOkayama University

Principal Investigator

MIYOSHI Toru  岡山大学, 大学病院, 講師 (70444651)

Co-Investigator(Kenkyū-buntansha) 中村 一文  岡山大学, 医歯薬学総合研究科, 准教授 (10335630)
米澤 朋子  岡山大学, 医歯薬学総合研究科, 助教 (30304299)
吉田 賢司  岡山大学, 医歯薬学総合研究科, 講師 (70532761)
伊藤 浩  岡山大学, 医歯薬学総合研究科, 教授 (90446047)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords腹部大動脈瘤 / 接着因子 / インテグリン / 細胞外マトリックス / integrin / extracellular matrix
Outline of Final Research Achievements

Abdominal aortic aneurysm is a silent disease, but lethal once ruptured. The prevention of AAA expansion and rupture is clinically difficult. This study investigated whether alpha1 integrin, an adhesion molecule, is involved in the development of AAA in murine model. Genetic deficiency of alpha1 integrin suppressed the rupture of AAA in angiotensin II infusion model. These findings suggest that alpha1 integrin may be a promising target to treat AAA.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (8 results)

All 2017 2016 2015

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 1 results) Presentation (5 results) (of which Int'l Joint Research: 3 results)

  • [Journal Article] Effect of Azilsartan on Day-to-Day Variability in Home Blood Pressure: A Prospective Multicenter Clinical Trial.2017

    • Author(s)
      Miyoshi T, Suetsuna R, Tokunaga N, Kusaka M, Tsuzaki R, Koten K, Kunihisa K, Ito H.
    • Journal Title

      J Clin Med Res.

      Volume: 9 Issue: 7 Pages: 618-623

    • DOI

      10.14740/jocmr3050w

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparable effect of aliskiren or a diuretic added on an angiotensin II receptor blocker on augmentation index in hypertension: a multicentre, prospective, randomised study.2017

    • Author(s)
      Miyoshi T, Murakami T, Sakuragi S, Doi M, Nanba S, Mima A, Tominaga Y, Oka T,
    • Journal Title

      Open Heart.

      Volume: 4 Issue: 1 Pages: e000591-e000591

    • DOI

      10.1136/openhrt-2017-000591

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 77.Impact of Ezetimibe Alone or in Addition to a Statin on Plasma PCSK9 Concentrations in Patients with Type 2 Diabetes and Hypercholesterolemia: A Pilot Study.2015

    • Author(s)
      Miyoshi T, Nakamura K, Doi M, Ito H.
    • Journal Title

      Am J Cardiovasc Drugs

      Volume: 15(3) Issue: 3 Pages: 213-219

    • DOI

      10.1007/s40256-015-0119-2

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Remote ischemic preconditioning prevents contrast induced acute kidney injury in patients with stable coronary artery disease following elective PCI: results from the multicenter randomised study2017

    • Author(s)
      H. Otsuka, T. Miyoshi, K. Ejiri, K. Kohno, M. Nakahama, M. Doi, M. Munemasa, M. Murakami, A. Takaishi, K. Nakamura, H. Ito
    • Organizer
      ESC2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Cardio-ankle vascular index, a novel parameter of subclinical atherosclerosis predicts prognosis in patients at high risk for cardiovascular disease2017

    • Author(s)
      T. Ono T. Miyoshi Y. Ohno G. Syokoku K. Yamamoto K. Tokioka Y. Kawai H. Ito
    • Organizer
      ESC2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Significant impact of type 2 diabetes mellitus on the association of arterial stiffness with left ventricular hypertrophy and left ventricular diastolic function2017

    • Author(s)
      Y. Ohno T. Miyoshi T. Ono K. Nakamura H. Morita H. Ito
    • Organizer
      ESC2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] LCZ696はイソプロテレノール持続投与によって誘発されるラット心筋線維化を抑制する2016

    • Author(s)
      三好 亨、中村一文、伊藤 浩
    • Organizer
      第20回日本心不全学会学術集会
    • Place of Presentation
      ロイトン札幌(北海道札幌市)
    • Year and Date
      2016-10-07
    • Related Report
      2016 Research-status Report
  • [Presentation] Low number of Circulating CD34 Positive Cell is Associated With Greater Progression of Coronary Calcium Determined by MDCT2016

    • Author(s)
      三好 亨
    • Organizer
      第80回日本循環器学会総会
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2016-03-17
    • Related Report
      2015 Research-status Report

URL: 

Published: 2015-04-16   Modified: 2019-03-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi