Development of new treatments with suppression of RAGE signal for pulmonary hypertension
| Project/Area Number |
15K09158
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cardiovascular medicine
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| Research Institution | Okayama University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
赤木 達 岡山大学, 医歯薬学総合研究科, 助教 (60601127)
阪口 政清 岡山大学, 医歯薬学総合研究科, 准教授 (70379840)
伊藤 浩 岡山大学, 医歯薬学総合研究科, 教授 (90446047)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 肺高血圧症 / ナノメディシン / 終末糖化産物受容体 / 肺動脈平滑筋細胞 / drug delivery system / 細胞増殖 / 右室収縮期圧 / 右室肥大 / 肺高血圧 / 血小板由来増殖因子 / S100蛋白 / TIRAP / 炎症 |
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| Outline of Final Research Achievements |
1.After a single administration, imatinib or beraprost-nanoparticles significantly decreased right ventricular pressure and right ventricular hypertrophy in rat models of pulmonary arterial hypertension (PAH).
2.Pulmonary artery smooth muscle cells of PAH (PAH-PASMCs) were hyperplastic. AS-1, an inhibitor of TIR domain-mediated RAGE signaling, significantly inhibited overgrowth in PAH-PASMCs.
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Report
(4 results)
Research Products
(21 results)
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[Journal Article] Reverse Right Ventricular Remodeling After Lung Transplantation in Patients With Pulmonary Arterial Hypertension Under Combination Therapy of Targeted Medical Drugs2017
Author(s)
Sarashina T, Nakamura K, Akagi S, Oto T, Oe H, Ejiri K, Nakagawa K, Nishii N, Matsubara H, Kobayashi M, Morimatsu H, Miyoshi S, Ito H
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Journal Title
Circulation Journal
Volume: 81
Issue: 3
Pages: 383-390
DOI
NAID
ISSN
1346-9843, 1347-4820
Related Report
Peer Reviewed / Open Access
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[Journal Article] Nanoparticle-mediated drug delivery system for pulmonary arterial hypertension2017
Author(s)
Nakamura K, Matsubara H, Akagi S, Sarashina T, Ejiri K, Kawakita N, Yoshida M, Miyoshi T, Watanabe A, Nishii N, Ito H.
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Journal Title
J Clin Med
Volume: 6
Issue: 5
Pages: 48-48
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] High Frequency of Acute Adverse Cardiovascular Events After Lung Transplantation in Patients With Pulmonary Arterial Hypertension Receiving Preoperative Long-Term Intravenous Prostacyclin2017
Author(s)
Akagi S, Oto T, Kobayashi M, Miyoshi K, Sugimoto S, Yamane M, Nakamura K, Sarashina T, Miyoshi S, Ito H
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Journal Title
International Heart Journal
Volume: 58
Issue: 4
Pages: 557-561
DOI
NAID
ISSN
1349-2365, 1349-3299
Related Report
Peer Reviewed
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[Journal Article] Nanoparticle-mediated Drug Delivery System for Pulmonary Arterial Hypertension2017
Author(s)
Nakamura K, Matsubara H, Akagi S, Sarashina T, Ejiri K, Kawakita N, Yoshida M, Miyoshi T, Watanabe A, Nishii N, Ito H
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Journal Title
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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