Elucidation of the molecular mechanism underlying the vascular dysfunction mediated by proteinase-activated receptor 1
| Project/Area Number |
15K09159
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Cardiovascular medicine
|
|---|
| Research Institution | Kyushu University |
|---|
Principal Investigator |
Hirano Mayumi 九州大学, 医学研究院, 助教 (80336031)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
平野 勝也 香川大学, 医学部, 教授 (80291516)
|
|---|
| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
|---|
| Keywords | プロテイナーゼ活性化型受容体(PAR1) / 血管内皮細胞 / 血管透過性 / 内皮バリアー障害 / ミオシン軽鎖リン酸化 / アクチン / 血管平滑筋細胞 / 肺高血圧症 / 内皮細胞 / トロンビン受容体 / バリアー機能障害 / アクチンストレスファイバー / Rhoキナーゼ / プロテイナーゼ活性化型受容体１ / 血管バリアー機能障害 / トロンビン / 脱感作障害 / 凝固因子XI / 血管病 |
|---|
| Outline of Final Research Achievements |
1. Myosin di-phosphorylation and peripheral actin bundle formation as initial events during endothelial barrier disruption. 2. The Rho-Rho kinase pathway plays an important role in the peripheral localization of ppMLC and actin filament formation during the initial phase of the thrombin-induced endothelial barrier disruption. 3. The coagulation factor XIa induces Ca2+ signal via proteinase-activated receptor 1(PAR1) and L-type Ca2+channel in vascular smooth muscle cells. 4. Specific and increased expression of thrombin receptor PAR1 in pulmonary artery plays a key role in the pathogenesis of monocrotaline-induced pulmonary hypertension in rats.
|
Report
(4 results)
Research Products
(18 results)
