Efficacy of inhibition of Nampt in KRAS mutated non-small cell lung cancer
Project/Area Number |
15K09165
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Respiratory organ internal medicine
|
Research Institution | Asahikawa Medical College |
Principal Investigator |
|
Project Period (FY) |
2015-04-01 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
|
Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
Keywords | KRAS / NSCLC / Nampt / 肺癌 |
Outline of Final Research Achievements |
The aim of our study is to evaluate efficacy of nampt inhibitor in KRAS mutated non-small cell lung cancer (NSCLC) and to study the mechanisms. We found that KRAS mutated NSCLC cell lines were divided into three groups; cell lines sensitive to FK866, a nampt inhibitor; those resistant to the inhibitor; intermediate sensitivity. Our study revealed that FK866 inhibited phosphorylation of Rb at ser 807/811, suppressed MAPK signaling pathways, decreased phosphorylation of Bim at ser 69, and increased γH2AX levels. These findings suggest that the nampt inhibitor causes DNA damage, suppresses cell cycle through alteration of Rb and MAPK pathways, and induces apoptosis through stabilization of Bim.
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Report
(4 results)
Research Products
(36 results)
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Kitada, M., Yasuda, S., Takahashi, N., Okazaki, S., Ishibashi, K., Hayashi, S., Ohsaki, Y., Miyokawa, N.
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Journal Title
Journal of Cardiothoracic Surgery
Volume: 11(1)
Issue: 1
Pages: 49-49
DOI
NAID
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Peer Reviewed / Open Access / Int'l Joint Research
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Satoru Fujiuchi, Yuka Fujita, Hokuto Suzuki, Kazushi Doushita, Hikaru Kuroda, Masaaki Takahashi, Yasuhiro Yamazaki,Tadakatsu Tsuji, Toshiaki Fujikane, Shinobu Osanai, Takaaki Sasaki, Yoshinobu Ohsaki
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Journal Title
Journal of Clinical Microbiology
Volume: 54(6)
Issue: 6
Pages: 1496-1499
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Peer Reviewed
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[Journal Article] Minimal Change Nephrotic Syndrome Associated with Gefitinib and a Successful Switch to Erlotinib2015
Author(s)
Maruyama K, Chinda J, Kuroshima T, Kabara M, Nakagawa N, Fujino T, Yamamoto Y, Ohsaki Y, Ogawa Y, Hasebe N.
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Journal Title
Internal Medicine
Volume: 54
Issue: 7
Pages: 823-826
DOI
NAID
ISSN
0918-2918, 1349-7235
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Open-label, randomized, comparative, phase Ⅲ study on effects of reducing steroid use in combination with Palonosetron2015
Author(s)
Yoshito Komatsu, Kenji Okita, Satoshi Yuki, Tomohisa Furuhata, Hikaru Fukushima, Hiroyuki Masuko, Yasuyuki Kawamoto, Hiroshi Isobe, Takuto Miyagishima, Kazuaki Sasaki, Michio Nakamura, Yoshinobu Ohsaki, et al
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Journal Title
Cancer Science
Volume: 106
Issue: 7
Pages: 891-895
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] 肺内に発生した異所性胸腺腫の1例2017
Author(s)
山本 泰司, 木田 涼太郎, 梅影 泰寛, 鳴海 圭倫, 吉田 遼平, 平井 理子, 風林 佳大, 奥村 俊介, 佐々木 高明, 大崎 能伸, 三代川 斎之
Organizer
第113回日本呼吸器学会北海道支部学術集会
Place of Presentation
札幌市教育文化会館 (札幌市)
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Author(s)
平井 理子, 風林 佳大, 梅影 泰寛, 鳴海 圭倫, 奥村 俊介, 佐々木 高明, 山本 泰司, 長内 忍, 大崎 能伸
Organizer
第37回日本レーザー医学会総会
Place of Presentation
旭川グランドホテル (旭川市)
Year and Date
2016-10-21
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