| Project/Area Number |
15K09168
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Niigata University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
各務 博 埼玉医科大学, 医学部, 教授 (30418686)
吉澤 弘久 新潟大学, 医歯学総合病院, 特任教授 (50282984)
三浦 理 新潟大学, 医歯学総合病院, その他 (70420320)
中田 光 新潟大学, 医歯学総合病院, 教授 (80207802)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 免疫療法 / PD-1 / T細胞 / PD-L1 / Adoptive immunotherapy / adoptive immunotherapy / lymphodepletion |
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| Outline of Final Research Achievements |
We previously reported that the induction of effector T cells was enhanced during immune reconstitution after chemotherapy. In the current study, we found that antitumor effects of anti-PD-1 therapy was augmented when combined with immune reconstitution mediated by chemotherapy. This enhancement of anti-PD-1 therapy was observed even in PD-L1 negative tumors. FACS analyses revealed that PD-L1 was expressed on tumor-infiltration immune cells. These findings indicated that effector T cells were suppressed by PD-L1 expressed on tumor-infiltration immune cells.
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