Novel antitumor immunotherapy via immune reconstitution after chemotherapy for advanced lung cancer
Project/Area Number |
15K09168
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Respiratory organ internal medicine
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Research Institution | Niigata University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
各務 博 埼玉医科大学, 医学部, 教授 (30418686)
吉澤 弘久 新潟大学, 医歯学総合病院, 特任教授 (50282984)
三浦 理 新潟大学, 医歯学総合病院, その他 (70420320)
中田 光 新潟大学, 医歯学総合病院, 教授 (80207802)
|
Project Period (FY) |
2015-04-01 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
|
Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | 免疫療法 / PD-1 / T細胞 / PD-L1 / Adoptive immunotherapy / adoptive immunotherapy / lymphodepletion |
Outline of Final Research Achievements |
We previously reported that the induction of effector T cells was enhanced during immune reconstitution after chemotherapy. In the current study, we found that antitumor effects of anti-PD-1 therapy was augmented when combined with immune reconstitution mediated by chemotherapy. This enhancement of anti-PD-1 therapy was observed even in PD-L1 negative tumors. FACS analyses revealed that PD-L1 was expressed on tumor-infiltration immune cells. These findings indicated that effector T cells were suppressed by PD-L1 expressed on tumor-infiltration immune cells.
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Report
(4 results)
Research Products
(11 results)
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[Journal Article] Updated survival outcomes of NEJ005/TCOG0902: a randomised phase II study of concurrent versus sequential alternating gefitinib and chemotherapy in previously untreated non-small cell lung cancer with sensitive EGFR mutations.2018
Author(s)
Oizumi S, Sugawara S, Minato K, Harada T, Inoue A, Fujita Y, Maemondo M, Watanabe S, Ito K, Gemma A, Demura Y, Fukumoto S, Isobe H, Kinoshita I, Morita S, Kobayashi K, Hagiwara K, Aiba K, Nukiwa T.
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Journal Title
ESMO Open
Volume: 3(2)
Issue: 2
Pages: e000313-e000313
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Nephrotoxicity of cisplatin combination chemotherapy in thoracic malignancy patients with CKD risk factors.2016
Author(s)
Ko Sato, Satoshi Watanabe,corresponding author Aya Ohtsubo, Satoshi Shoji, Daisuke Ishikawa, Tomohiro Tanaka, Koichiro Nozaki, Rie Kondo, Masaaki Okajima, Satoru Miura, Junta Tanaka, Takuro Sakagami, Toshiyuki Koya, Hiroshi Kagamu, Hirohisa Yoshizawa, and Ichiei Narita
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Journal Title
BMC Cancer
Volume: 16(1)
Issue: 1
Pages: 222-222
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Critical Roles of Chemoresistant Effector and Regulatory T Cells in Antitumor Immunity after Lymphodepleting Chemotherapy.2015
Author(s)
Saida Y, Watanabe S, Tanaka T, Baba J, Sato K, Shoji S, Igarashi N, Kondo R, Okajima M, Koshio J, Ichikawa K, Nozaki K, Ishikawa D, Koya T, Miura S, Tanaka J, Kagamu H, Yoshizawa H, Nakata K, Narita I
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Journal Title
Journal of immunology
Volume: 195
Pages: 726-735
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Presentation] Lymphodepletion induces T cell homeostatic proliferation and augments antitumor effects of PD-1/PD-L1 blockade therapy.2017
Author(s)
Masashi Arita, Satoshi Watanabe, Miho Takahashi, Miyuki Sato, Aya Ohtsubo, Kosuke Ichikawa, Rie Kondo, Tetsuya Abe, Junta Tanaka, Toshiyuki Koya, Toshiaki Kikuchi
Organizer
American Association for Cancer Research
Related Report
Int'l Joint Research
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[Presentation] Programmed death receptor-1/programmed death receptor ligand-1 blockade improves priming of antitumor effector T cells after cytotoxic therapies2016
Author(s)
Miho Takahashi, Satoshi Watanabe, Ko Sato, Tomohiro Tanaka, Yu Saida, Junko Baba, Aya Ohtsubo, Miyuki Sato, Rie Kondo, Masaaki Okajima, Junta Tanaka, Hiroshi Kagamu, Hirohisa Yoshizawa, Toshiaki Kikuchi
Organizer
Annual meeting of american association for cancer research
Place of Presentation
New Orleans (アメリカ合衆国)
Year and Date
2016-04-16
Related Report
Int'l Joint Research
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[Presentation] Critical roles of chemo-resistant effector and regulatory T cells in cancer immunotherapy during hemostatic proliferation2015
Author(s)
Ko Sato, Satoshi Watanabe, Yu Saida, Tomohiro Tanaka, Junko Baba, Aya Ohtsubo, Satoshi Shoji, Daisuke Ishikawa, Rie Kondo, Masaaki Okajima, Satoru Miura, Junta Tanaka, Hiroshi Kagamu, Hirohisa Yoshizawa, Ichiei Narita
Organizer
Annual meeting of american association for cancer research
Place of Presentation
Philadelphia, USA
Year and Date
2015-04-18
Related Report
Int'l Joint Research