| Project/Area Number |
15K09169
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Shinshu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
川上 聡 信州大学, 学術研究院医学系, 助教 (20324254)
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| Project Period (FY) |
2015-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | サルコイドーシス / IgG4関連疾患 / 気管支肺胞洗浄 / CCL1 / サイトカイン / IgG4 / 気管支肺胞洗浄（BAL）液 / BAL（気管支肺胞洗浄） / IgG4関連疾患（IgG4-RD） / 気管支肺胞洗浄（BAL） |
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| Outline of Final Research Achievements |
We reported that the cytokines in the bronchoalveolar lavage fluid (BALF) of IgG4-related respiratory disease (IgG4-RRD) more closely resemble the Th 2 response than sarcoidosis. This study aimed to assess the chemokines in the BALF of IgG4-RRD and sarcoidosis and evaluate any possible associations with other markers.
We examined 12 chemokines in the same BALF samples of the same 44 patients (IgG4-RRD, n=11; sarcoidosis, n=33) in which we had previously evaluated the cytokines. The BALF levels of CCL1 in the sarcoidosis (median 13.1(0.1-106.9) pg/mL) were significantly higher than those of the IgG4-RRD (9.8(0.1-14.7) pg/mL, p<0.05). The CCL1 levels in the BALF were correlated with the total cell count (R=0.539, p<0.001), lymphocyte count (R=0.686, P<0.001), TNF-α(R=0.748, P<0.001), and IL-2 (R=0.757, P<0.001) in the BALF of sarcoidosis. CCL1 might reflect disease activity and its involvement in the pathogenesis of sarcoidosis might be more closely related to Th1 than to Th2.
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| Academic Significance and Societal Importance of the Research Achievements |
一般に、CCL1は気管支喘息やアトピー性皮膚炎などTh2関連の疾患に関与されていると認識されている。本研究で、Th1優位のSarcoidosis（Sa）の気管支肺胞洗浄（BAL）液中でCCL1が、Th2優位のIgG4関連呼吸器疾患（IgG4-RRD）よりも有意に高値であることを示した。さらに、SaにおいてBAL液中CCL1はBAL液中総細胞数、リンパ球数、Th1関連のサイトカインと有意な相関が認められた。SaとCCL1に関連する報告は検索した範囲でなく、CCL1がSaのTh1に関連した病勢を反映していることを初めて報告した。今後、CCL1がSaのバイオマーカーになる可能性について検証したい。
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