Comparison of the chemokine profiles in the bronchoalveolar lavage fluid between IgG4-related respiratory disease and sarcoidosis
| Project/Area Number |
15K09169
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Shinshu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
川上 聡 信州大学, 学術研究院医学系, 助教 (20324254)
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| Project Period (FY) |
2015-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | サルコイドーシス / IgG4関連疾患 / 気管支肺胞洗浄 / CCL1 / サイトカイン / IgG4 / 気管支肺胞洗浄（BAL）液 / BAL（気管支肺胞洗浄） / IgG4関連疾患（IgG4-RD） / 気管支肺胞洗浄（BAL） |
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| Outline of Final Research Achievements |
We reported that the cytokines in the bronchoalveolar lavage fluid (BALF) of IgG4-related respiratory disease (IgG4-RRD) more closely resemble the Th 2 response than sarcoidosis. This study aimed to assess the chemokines in the BALF of IgG4-RRD and sarcoidosis and evaluate any possible associations with other markers.
We examined 12 chemokines in the same BALF samples of the same 44 patients (IgG4-RRD, n=11; sarcoidosis, n=33) in which we had previously evaluated the cytokines. The BALF levels of CCL1 in the sarcoidosis (median 13.1(0.1-106.9) pg/mL) were significantly higher than those of the IgG4-RRD (9.8(0.1-14.7) pg/mL, p<0.05). The CCL1 levels in the BALF were correlated with the total cell count (R=0.539, p<0.001), lymphocyte count (R=0.686, P<0.001), TNF-α(R=0.748, P<0.001), and IL-2 (R=0.757, P<0.001) in the BALF of sarcoidosis. CCL1 might reflect disease activity and its involvement in the pathogenesis of sarcoidosis might be more closely related to Th1 than to Th2.
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| Academic Significance and Societal Importance of the Research Achievements |
一般に、CCL1は気管支喘息やアトピー性皮膚炎などTh2関連の疾患に関与されていると認識されている。本研究で、Th1優位のSarcoidosis（Sa）の気管支肺胞洗浄（BAL）液中でCCL1が、Th2優位のIgG4関連呼吸器疾患（IgG4-RRD）よりも有意に高値であることを示した。さらに、SaにおいてBAL液中CCL1はBAL液中総細胞数、リンパ球数、Th1関連のサイトカインと有意な相関が認められた。SaとCCL1に関連する報告は検索した範囲でなく、CCL1がSaのTh1に関連した病勢を反映していることを初めて報告した。今後、CCL1がSaのバイオマーカーになる可能性について検証したい。
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Report
(5 results)
Research Products
(15 results)
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[Journal Article] Comparison of the chemokine profiles in the bronchoalveolar lavage fluid between IgG4-related respiratory disease and sarcoidosis: CC-chemokine ligand 1 might be involved in the pathogenesis of sarcoidosis.2019
Author(s)
Yamamoto H, Yasuo M, Komatsu M, Ushiki A, Hamano H, Hori A, Nakajima T, Uehara T, Fujinaga Y, Matsui S, Hanaoka M.
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Journal Title
Cytokine
Volume: 120
Pages: 125-129
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Serum soluble interleukin-2 receptor as a biomarker in immunoglobulin G4-related disease.2018
Author(s)
Handa T, Matsui S, Yoshifuji H, Kodama Y, Yamamoto H, Minamoto S, Waseda Y, Sato Y, Kubo K, Mimori T, Chiba T, Hirai T, Mishima M.
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Journal Title
Mod Rheumatol
Volume: 8
Pages: 1-7
Related Report
Peer Reviewed
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[Presentation] サルコイドーシスのBAL液中各種メディエーターの解析－IgG4関連吸器疾患との比較－.2019
Author(s)
山本 洋, 安尾将法, 小松雅宙, 曽根原 圭, 市山崇史, 立石一成, 牛木淳人, 漆畑一寿, 花岡正幸, 川上 聡, 堀 敦詞, 上原 剛, 浜野英明, 川 茂幸, 松井祥子.
Organizer
第38回日本サルコイドーシス／肉芽腫性疾患学会総会
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