Prevalence of COPD and subclinical arteriosclerosis in Japanese general population

• Project/Area Number: 15K09171
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Respiratory organ internal medicine
• Research Institution: Shiga University of Medical Science
• Principal Investigator: Nakano Yasutaka 滋賀医科大学, 医学部, 准教授 (00362377)
• Co-Investigator(Kenkyū-buntansha): 小川 恵美子 滋賀医科大学, 医学部, 講師 (00378671) ; 上島 弘嗣 滋賀医科大学, アジア疫学研究センター, 特任教授 (70144483) ; 久松 隆史 島根大学, 医学部, 准教授 (60710449)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 慢性閉塞性肺疾患 / 呼吸機能検査 / 動脈硬化 / 脳MRI / 白質病変 / ラクナ梗塞 / 疫学研究 / 潜在性動脈硬化指標 / 頭部MRI検査

Outline of Final Research Achievements

Chronic Obstructive Pulmonary disease (COPD) is one of the most important diseases in Japan. About 500 men aged over 40 years, who were recruited from a general population of Kusatsu city in Shiga Prefecture, underwent lung function tests and brain MRI. The prevalence of COPD was revealed to be about 15%. An association was found between reduced lung function and the white matter lesions and lacunar infarcts in never smokers.

Research Products

• [Journal Article] Reduced Lung Function and Cerebral Small Vessel Disease in Japanese Men: the Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA) (2018)
  • Author(s): Seto-Yukimura R, Ogawa E, Hisamatsu T, Torii S, Shiino A, Nozaki K, Fujiyoshi A, Miura K, Nakano Y, Ueshima H
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 25 Issue: 10 Pages: 1009-1021
  • DOI: 10.5551/jat.42127
  • NAID: 130007493888
  • ISSN: 1340-3478, 1880-3873
  • Year and Date: 2018-10-01
  • Peer Reviewed / Open Access