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Quantitative assessment of extra-cellar matrix in diseased lung, during regeneration, hyperinflation, and development of emphysema

Research Project

Project/Area Number 15K09172
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Respiratory organ internal medicine
Research InstitutionKyoto University

Principal Investigator

Sato Susumu  京都大学, 医学研究科, 助教 (40378691)

Co-Investigator(Kenkyū-buntansha) 陳 豊史  京都大学, 医学研究科, 講師 (00452334)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords細胞外マトリックス / 肺気腫 / メカニクス / 不均一性
Outline of Final Research Achievements

Elastase induced lung injury (emphysematous lesion) in model mouse represent significant relationship with respiratory mechanical property measured by forced oscillation technique. In addition, cranial-caudal heterogeneity of emphysema showed significant and independent association with heterogeneity of elastane (SD of H). These associations were preserved in acute model (3 weeks after injury) and chronic model (13 weeks after injury). However, in chronic model, airway resistance (Raw) also showed significant association and may suggest difference of structure-function relationship in development of emphysema.
Dose dependent effect of elastane in development of emphysema showed ceiling-effect in chronic model.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (4 results)

All 2017

All Presentation (4 results)

  • [Presentation] エラスターゼ傷害肺気腫マウスにおける 呼吸インピーダンスと胸部CT画像解析による機能的・構造的不均一性の検討2017

    • Author(s)
      佐藤 晋
    • Organizer
      日本呼吸器学会学術集会
    • Place of Presentation
      東京国際フォーラム (東京都)
    • Year and Date
      2017-04-22
    • Related Report
      2016 Research-status Report
  • [Presentation] エラスターゼ傷害肺気腫マウスにおける呼吸インピーダンス測定と定量的胸部CTによる機能的・構造的不均一性の関連性2017

    • Author(s)
      佐藤 晋
    • Organizer
      呼吸機能イメージング研究会学術集会
    • Place of Presentation
      京都大学百周年時計台記念館 (京都市)
    • Year and Date
      2017-01-28
    • Related Report
      2016 Research-status Report
  • [Presentation] エラスターゼ傷害肺気腫マウスにおける呼吸インピーダンス測定と定量的胸部CTによる機能的・構造的不均一性の関連性2017

    • Author(s)
      佐藤 晋
    • Organizer
      日本呼吸器学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] エラスターゼ傷害肺気腫マウスにおける呼吸インピーダンス測定と定量的胸部CTによる機能的・構造的不均一性の関連性2017

    • Author(s)
      佐藤 晋
    • Organizer
      呼吸機能イメージング研究会
    • Related Report
      2017 Annual Research Report

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Published: 2015-04-16   Modified: 2019-03-29  

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