Diagnosis methods of lung adenocarcinoma using analysis of urinary protein fragments

• Project/Area Number: 15K09177
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Respiratory organ internal medicine
• Research Institution: University of Miyazaki
• Principal Investigator: MATSUMOTO NOBUHIRO 宮崎大学, 医学部, 助教 (70418838)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 肺癌 / 早期診断 / 尿 / 蛋白断片 / がん診断マーカー / シェディング / 癌特異的酵素 / 尿中蛋白断片 / 癌マーカー

Outline of Final Research Achievements

In this research, we found several urinary protein fragments, which are early diagnosis markers for brain metastasis and bone metastasis of lung adenocarcinoma. These protein fragments are thought to be produced by cancer specific proteinase activity.
Some of these protein fragments are from alpha-1-microglobulin/bikunin precursor.