exhaled nitric oxide as a novel biomarker for predicting exacerbation of chronic obstructive pulmonary disease
| Project/Area Number |
15K09182
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Fukushima Medical University |
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Principal Investigator |
Saito Junpei 福島県立医科大学, 医学部, 講師 (50332929)
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| Project Period (FY) |
2015-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 呼気硫化水素 / 慢性閉塞性肺疾患 / 気管支喘息 / 呼気ガス分析 / 硫化水素 |
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| Outline of Final Research Achievements |
We developed a new exhaled hydrogen sulfide (eH2S) measurement system and applied for a patent on this. Then, eH2S were measured twice in 57 subjects to evaluate whether obtained eH2S levels are reproducible. The coefficient of variation of eH2S levels was 2.90±2.32%, indicating eH2S levels measured by this system were reproducible. Next, eH2S levels were also measured in healthy, COPD and asthmatic subjects. The eH2S levels in subjects with asthma and COPD were significantly higher than those in healthy subjects. In addition, there was a trend correlation between eH2S and COPD severities. Furthermore, significant positive correlations can be seen between eH2S and sputum neutrophils as well as sputum H2S, and significant negative correlation can also be seen between eH2S and FEV1/FVC as well as FEV1 %predicted. Taking these results into consideration, eH2S may provide useful information on predicting not only neutrophilic airway inflammation but also airflow obstruction in COPD.
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| Academic Significance and Societal Importance of the Research Achievements |
これまで好中球性気道炎症を検出する有用なバイオマーカーはなかった．我々は呼気中硫化水素（exhaled hydrogen sulfide: eH2S）が好中球性気道炎症の簡便かつ鋭敏で非侵襲的な指標となりうることを世界で初めて見出した．本研究成果からは、難治性喘息や慢性閉塞性疾患（COPD）を代表とする好中球性気道疾患のみならず肺炎等の好中球性炎症をきたす呼吸器疾患全般における予後や疾患活動性の指標としてもeH2Sが利用できる可能性を示唆しており、今後の日常診療への応用が大いに期待される結果であった．
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Report
(5 results)
Research Products
(102 results)
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[Journal Article] Authors' response2018
Author(s)
Sato Suguru、Saito Junpei
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Journal Title
Annals of Allergy, Asthma & Immunology
Volume: 120
Issue: 3
Pages: 341-341
DOI
Related Report
Peer Reviewed
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[Journal Article] Serum decorin is a potent prognostic biomarker in acute exacerbation of idiopathic pulmonary fibrosis2018
Author(s)
Nikaido T, Tanino Y, Wang X, Sato Y, Togawa R, Kikuchi M, Misa K, Saito K, Fukuhara N, Kawamata T, Rikimaru M, Umeda T, Morimoto J, Koizumi T, Suzuki Y, Hirai K, Uematsu M, Minemura H, Fukuhara A, Sato S, Saito J, Yokouchi H, Kanazawa K, Shibata
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Journal Title
J Thorac Dis
Volume: 10
Issue: 9
Pages: 5346-58
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Cholesteryl palmitate crystals in bronchoalveolar lavage fluid smears as a possible prognostic biomarker for chronic interstitial pneumonia: A preliminary study.2016
Author(s)
Fukuhara N, Tachihara M, Tanino Y, Saito J, Sato S, Nikaido T, Misa K, Fukuhara A, Wang X, Ishida T, Onami T, Munakata M.
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Journal Title
Respir Investig.
Volume: 54
Issue: 2
Pages: 109-115
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Association between typhoon and asthma symptoms in Japan.2016
Author(s)
Sato S, Saito J, Suzuki Y, Uematsu M, Fukuhara A, Togawa R, Sato Y, Misa K, Nikaido T, Wang X, Tanino Y, Munakata M.
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Journal Title
Respir Investig
Volume: 54
Issue: 3
Pages: 216-219
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Exhaled nitric oxide and inducible nitric oxide synthase gene polymorphism in Japanese asthmatics2015
Author(s)
Sato S, Wang X, Saito J, Fukuhara A, Uematsu M, Suzuki Y, Sato Y, Misa K, Nikaido T, Fukuhara N, Tanino Y, Munakata M.
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Journal Title
Allergology International
Volume: 65
Issue: 3
Pages: 300-305
DOI
NAID
ISSN
1323-8930, 1440-1592
Related Report
Peer Reviewed / Open Access
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[Journal Article] Secretoglobin 3A2 Attenuates Lipopolysaccharide-Induced Inflammation Through Inhibition of ERK and JNK Pathways in Bronchial Epithelial Cells.2015
Author(s)
Wang X, Tanino Y, Sato S, Nikaido T, Misa K, Fukuhara N, Fukuhara A, Saito J, Yokouchi H, Ishida T, Fujita T, Munakata M.
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Journal Title
Inflammation
Volume: 38
Issue: 2
Pages: 828-834
DOI
Related Report
Peer Reviewed
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[Journal Article] Early detection of colon cancer by increased serum level of Krebs von den Lungen-6 in a patient with dermatomyositis-associated interstitial pneumonia.2015
Author(s)
Fukuhara N, Tanino Y, Sato S, Fukuhara A, Uematsu M, Nikaido T, Misa K, Sato Y, Saito J, Wang X, Munakata M.
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Journal Title
Sarcoidosis Vasc Diffuse Lung Dis.
Volume: 32
Pages: 265-270
Related Report
Peer Reviewed
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[Presentation] Comparison of fractional exhaled nitric oxide (FeNO) levels measured by different analysers.2018
Author(s)
Saito J, Rikimaru M, Kikuchi M, Fukuhara A, Sato S, Suzuki Y, Uematsu M, Fukuhara N, Kawamata T, Umeda T, Morimoto J, Togawa R, Sato Y, Koizumi T, Kenichiro H, Minemura H, Nikaido T, Kanazawa K, Tanino Y, Munakata M, Shibata Y.
Organizer
Annual Congress of European Respiratory Society
Related Report
Int'l Joint Research
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[Presentation] Association of asthma control test (ACT) and asthma control questionnaire (ACQ) with asthma exacerbation.2018
Author(s)
Uematsu M, Saito J, Sato S, Fukuhara A, Suzuki Y, Togawa Y, Sato Y, Nikaido T, Tanino Y, Munakata M, Shibata Y.
Organizer
Annual Congress of European Respiratory Society
Related Report
Int'l Joint Research
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[Presentation] The assessment of asthma with a novel 24-hour cough frequency monitor.2016
Author(s)
Saito J, Fukuhara A, Birring SS, Sato S, Uematsu M, Suzuki Y, Togawa R, Sato Y, Misa K, Nikaido T, Wang X, Tanino Y, Munakata M.
Organizer
The 41st International Lung Sound Association Conference 2016
Place of Presentation
Tokyo
Year and Date
2016-10-07
Related Report
Int'l Joint Research / Invited
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[Presentation] The assessment of asthma with a novel 24-hour cough frequency monitor.2016
Author(s)
Fukuhara A, Saito J, Birring SS, Sato S, Uematsu M, Suzuki Y, Togawa R, Sato Y, Misa K, Nikaido T, Wang X, Tanino Y, Munakata M.
Organizer
Annual Congress of European Respiratory Society
Place of Presentation
London
Year and Date
2016-09-03
Related Report
Invited
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[Presentation] Domiciliary diurnal variation of fractional exhaled nitric oxide (FeNO) for predicting short-term treatment effect.2016
Author(s)
Uematsu M, Saito J, Sato S, Fukuhara A, Suzuki S, Togawa R, Sato Y, Misa K, Nikaido T, Fukuhara N, Wang X, Tanino Y, Munakata M
Organizer
Annual Congress of European Respiratory Society
Place of Presentation
London
Year and Date
2016-09-03
Related Report
Int'l Joint Research
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[Presentation] Clinical application of hydrogen sulfide (H2S) as a marker of asthma management.2016
Author(s)
Suzuki Y, Saito J, Uematsu M, Fukuhara A, Sato S, Togawa R, Sato Y, Misa K, Nikaido T, Fukuhara N, Wang X, Tanino Y, Munakata M.
Organizer
Annual Congress of European Respiratory Society
Place of Presentation
London
Year and Date
2016-09-03
Related Report
Int'l Joint Research
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[Presentation] Association between cardio-ankle vascular index (CAVI) and chronic airway obstruction in asthma.2016
Author(s)
Sato S, Saito J, Fukuhara A, Uematsu M, Suzuki Y, Togawa R, Sato Y, Misa K, Nikaido T, Fukuhara N, Wang X, Tanino Y, Munakata M.
Organizer
Annual Congress of European Respiratory Society
Place of Presentation
London
Year and Date
2016-09-03
Related Report
Int'l Joint Research
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